FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017533277> ?p ?o ?g. }

• W2017533277 endingPage "548" @default.
• W2017533277 startingPage "541" @default.
• W2017533277 abstract "<title/> Objective: Nitric oxide (NO) has a variety of functions in physiological systems, particularly in the vasculature and the central nervous system. Currently, the imbalance of the pathway involving nitric oxide, nitric oxide synthase, and asymmetric dimethylarginine (NO-NOS-ADMA) is increasingly discussed in connection with endothelial dysfunction. Knowledge about the role of this pathway in intracerebral hemorrhage (ICH), which represents the most devastating stroke subtype, is increasing but still sparse. This article aims to review the current knowledge about the role and metabolism of NO and ADMA. It will also address the role of the NO-NOS-ADMA pathway in ICH and delineate some questions that should be addressed by future studies. Methods: A literature search regarding the data about NO, NOS, and ADMA and its role in ICH was conducted in PubMed. Results: Experimental data from cell culture and animal models indicate that, after the occurrence of ICH, neuronal and inducible nitric oxide synthases (nNOS and iNOS) are both overexpressed and uncoupled through the induction of blood compound metabolites, including thrombin and inflammatory mediators. ADMA, the most potent endogenous inhibitor of NOS, is also overproduced following dysregulation of its metabolizing enzymes. Dysfunction of the NO-NOS-ADMA pathway results in cell death, blood-brain barrier (BBB) disruption, and brain edema via different pathological mechanisms. However, the available data from clinical studies are still rare and partially contradictory. Conclusion: Experimental data suggest an important role for the NO-NOS-ADMA pathway for secondary injury after ICH. Since the literature shows contradictory results, further studies are needed to address current confusion." @default.
• W2017533277 created "2016-06-24" @default.
• W2017533277 creator A5003714713 @default.
• W2017533277 creator A5019108487 @default.
• W2017533277 creator A5031315906 @default.
• W2017533277 creator A5064943374 @default.
• W2017533277 creator A5068739017 @default.
• W2017533277 date "2011-06-01" @default.
• W2017533277 modified "2023-10-05" @default.
• W2017533277 title "Nitric oxide (NO) and asymmetric dimethylarginine (ADMA): their pathophysiological role and involvement in intracerebral hemorrhage" @default.
• W2017533277 cites W1821918060 @default.
• W2017533277 cites W1838231017 @default.
• W2017533277 cites W1966525844 @default.
• W2017533277 cites W1968778293 @default.
• W2017533277 cites W1972883438 @default.
• W2017533277 cites W1973223262 @default.
• W2017533277 cites W1977392263 @default.
• W2017533277 cites W1978648371 @default.
• W2017533277 cites W1984372361 @default.
• W2017533277 cites W1990311126 @default.
• W2017533277 cites W1992810156 @default.
• W2017533277 cites W1995977192 @default.
• W2017533277 cites W1999190313 @default.
• W2017533277 cites W1999944711 @default.
• W2017533277 cites W2001778442 @default.
• W2017533277 cites W2005706069 @default.
• W2017533277 cites W2012038403 @default.
• W2017533277 cites W2015295078 @default.
• W2017533277 cites W2025334605 @default.
• W2017533277 cites W2028376365 @default.
• W2017533277 cites W2029491963 @default.
• W2017533277 cites W2031800792 @default.
• W2017533277 cites W2039045136 @default.
• W2017533277 cites W2041075406 @default.
• W2017533277 cites W2043957477 @default.
• W2017533277 cites W2045964357 @default.
• W2017533277 cites W2046761882 @default.
• W2017533277 cites W2049751006 @default.
• W2017533277 cites W2050225709 @default.
• W2017533277 cites W2050740439 @default.
• W2017533277 cites W2051306731 @default.
• W2017533277 cites W2051809128 @default.
• W2017533277 cites W2053121015 @default.
• W2017533277 cites W2053834273 @default.
• W2017533277 cites W2060415257 @default.
• W2017533277 cites W2070993775 @default.
• W2017533277 cites W2072462206 @default.
• W2017533277 cites W2076628090 @default.
• W2017533277 cites W2076680300 @default.
• W2017533277 cites W2077232687 @default.
• W2017533277 cites W2077282638 @default.
• W2017533277 cites W2080572230 @default.
• W2017533277 cites W2087325680 @default.
• W2017533277 cites W2092145002 @default.
• W2017533277 cites W2093265564 @default.
• W2017533277 cites W2093565704 @default.
• W2017533277 cites W2093709800 @default.
• W2017533277 cites W2094585602 @default.
• W2017533277 cites W2099957438 @default.
• W2017533277 cites W2099988883 @default.
• W2017533277 cites W2103798426 @default.
• W2017533277 cites W2107017556 @default.
• W2017533277 cites W2110420172 @default.
• W2017533277 cites W2113607745 @default.
• W2017533277 cites W2115153703 @default.
• W2017533277 cites W2116527718 @default.
• W2017533277 cites W2119478101 @default.
• W2017533277 cites W2125271565 @default.
• W2017533277 cites W2127624569 @default.
• W2017533277 cites W2131461587 @default.
• W2017533277 cites W2132077512 @default.
• W2017533277 cites W2133076145 @default.
• W2017533277 cites W2133726488 @default.
• W2017533277 cites W2136587148 @default.
• W2017533277 cites W2140217457 @default.
• W2017533277 cites W2149823732 @default.
• W2017533277 cites W2149847034 @default.
• W2017533277 cites W2166969544 @default.
• W2017533277 cites W2169890089 @default.
• W2017533277 cites W2170750989 @default.
• W2017533277 cites W2170787120 @default.
• W2017533277 cites W2172046741 @default.
• W2017533277 cites W2415194500 @default.
• W2017533277 cites W2928618355 @default.
• W2017533277 cites W4210987237 @default.
• W2017533277 doi "https://doi.org/10.1179/016164111x13007856084403" @default.
• W2017533277 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21669125" @default.
• W2017533277 hasPublicationYear "2011" @default.
• W2017533277 type Work @default.
• W2017533277 sameAs 2017533277 @default.
• W2017533277 citedByCount "28" @default.
• W2017533277 countsByYear W20175332772012 @default.
• W2017533277 countsByYear W20175332772013 @default.
• W2017533277 countsByYear W20175332772014 @default.
• W2017533277 countsByYear W20175332772015 @default.
• W2017533277 countsByYear W20175332772016 @default.
• W2017533277 countsByYear W20175332772017 @default.
• W2017533277 countsByYear W20175332772018 @default.

• next