FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017533384> ?p ?o ?g. }

• W2017533384 abstract "As the average age of the population has increased, the incidence of age-related bone fracture has also increased. While some of the increase of fracture incidence with age is related to loss of bone mass, a significant part of the risk is unexplained and may be caused by changes in intrinsic material properties of the hard tissue. This investigation focused on understanding how changes to the intrinsic damage properties affect bone fragility. We hypothesized that the intrinsic (μm) damage properties of bone tissue strongly and nonlinearly affect mechanical behavior at the apparent (whole tissue, cm) level. The importance of intrinsic properties on the apparent level behavior of trabecular bone tissue was investigated using voxel based finite element analysis. Trabecular bone cores from human T12 vertebrae were scanned using microcomputed tomography (μCT) and the images used to build nonlinear finite element models. Isotropic and initially homogenous material properties were used for all elements. The elastic modulus (Ei) of individual elements was reduced with a secant damage rule relating only principal tensile tissue strain to modulus damage. Apparent level resistance to fracture as a function of changes in the intrinsic damage properties was measured using the mechanical energy to failure per unit volume (apparent toughness modulus, Wa) and the apparent yield strength (σay, calculated using the 0.2% offset). Intrinsic damage properties had a profound nonlinear effect on the apparent tissue level mechanical response. Intrinsic level failure occurs prior to apparent yield strength (σay). Apparent yield strength (σay) and toughness vary strongly (1200% and 400%, respectively) with relatively small changes in the intrinsic damage behavior. The range of apparent maximum stresses predicted by the models was consistent with those measured experimentally for these trabecular bone cores from the experimental axial compressive loading (experimental: σmax = 3.0–4.3 MPa; modeling: σmax = 2–16 MPa). This finding differs significantly from previous studies based on nondamaging intrinsic material models. Further observations were that this intrinsic damage model reproduced important experimental apparent level behaviors including softening after peak load, microdamage accumulation before apparent yield (0.2% offset), unload softening, and sensitivity of the apparent level mechanical properties to variability of the intrinsic properties." @default.
• W2017533384 created "2016-06-24" @default.
• W2017533384 creator A5005531876 @default.
• W2017533384 creator A5040045607 @default.
• W2017533384 creator A5049805492 @default.
• W2017533384 creator A5051263805 @default.
• W2017533384 date "2012-12-27" @default.
• W2017533384 modified "2023-09-26" @default.
• W2017533384 title "The Importance of Intrinsic Damage Properties to Bone Fragility: A Finite Element Study" @default.
• W2017533384 cites W1218970471 @default.
• W2017533384 cites W1824922455 @default.
• W2017533384 cites W1967356248 @default.
• W2017533384 cites W1971014905 @default.
• W2017533384 cites W1971167518 @default.
• W2017533384 cites W1971589882 @default.
• W2017533384 cites W1972326112 @default.
• W2017533384 cites W1972643303 @default.
• W2017533384 cites W1972766017 @default.
• W2017533384 cites W1975310744 @default.
• W2017533384 cites W1975609592 @default.
• W2017533384 cites W1979583938 @default.
• W2017533384 cites W1981811057 @default.
• W2017533384 cites W1990168612 @default.
• W2017533384 cites W1990411276 @default.
• W2017533384 cites W1994669017 @default.
• W2017533384 cites W1996870889 @default.
• W2017533384 cites W2007282895 @default.
• W2017533384 cites W2012209783 @default.
• W2017533384 cites W2016607160 @default.
• W2017533384 cites W2022836308 @default.
• W2017533384 cites W2029527712 @default.
• W2017533384 cites W2042695653 @default.
• W2017533384 cites W2043840576 @default.
• W2017533384 cites W2060678541 @default.
• W2017533384 cites W2068747322 @default.
• W2017533384 cites W2076266647 @default.
• W2017533384 cites W2081989536 @default.
• W2017533384 cites W2088835161 @default.
• W2017533384 cites W2088873760 @default.
• W2017533384 cites W2089968363 @default.
• W2017533384 cites W2090031445 @default.
• W2017533384 cites W2090310692 @default.
• W2017533384 cites W2095150495 @default.
• W2017533384 cites W2099359603 @default.
• W2017533384 cites W2100197086 @default.
• W2017533384 cites W2100597728 @default.
• W2017533384 cites W2101214241 @default.
• W2017533384 cites W2101676186 @default.
• W2017533384 cites W2116965611 @default.
• W2017533384 cites W2117729857 @default.
• W2017533384 cites W2125776903 @default.
• W2017533384 cites W2128822937 @default.
• W2017533384 cites W2131311648 @default.
• W2017533384 cites W2132170348 @default.
• W2017533384 cites W2135372180 @default.
• W2017533384 cites W2138907872 @default.
• W2017533384 cites W2145914528 @default.
• W2017533384 cites W2153483480 @default.
• W2017533384 cites W2153531042 @default.
• W2017533384 cites W2154263429 @default.
• W2017533384 cites W2155643998 @default.
• W2017533384 cites W2156139503 @default.
• W2017533384 cites W2162652878 @default.
• W2017533384 cites W2164057611 @default.
• W2017533384 cites W2164319357 @default.
• W2017533384 doi "https://doi.org/10.1115/1.4023090" @default.
• W2017533384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23363215" @default.
• W2017533384 hasPublicationYear "2012" @default.
• W2017533384 type Work @default.
• W2017533384 sameAs 2017533384 @default.
• W2017533384 citedByCount "11" @default.
• W2017533384 countsByYear W20175333842013 @default.
• W2017533384 countsByYear W20175333842014 @default.
• W2017533384 countsByYear W20175333842015 @default.
• W2017533384 countsByYear W20175333842017 @default.
• W2017533384 countsByYear W20175333842019 @default.
• W2017533384 countsByYear W20175333842020 @default.
• W2017533384 crossrefType "journal-article" @default.
• W2017533384 hasAuthorship W2017533384A5005531876 @default.
• W2017533384 hasAuthorship W2017533384A5040045607 @default.
• W2017533384 hasAuthorship W2017533384A5049805492 @default.
• W2017533384 hasAuthorship W2017533384A5051263805 @default.
• W2017533384 hasConcept C105702510 @default.
• W2017533384 hasConcept C112950240 @default.
• W2017533384 hasConcept C121332964 @default.
• W2017533384 hasConcept C127413603 @default.
• W2017533384 hasConcept C135628077 @default.
• W2017533384 hasConcept C136229726 @default.
• W2017533384 hasConcept C159985019 @default.
• W2017533384 hasConcept C184050105 @default.
• W2017533384 hasConcept C192562407 @default.
• W2017533384 hasConcept C193867417 @default.
• W2017533384 hasConcept C196029304 @default.
• W2017533384 hasConcept C2778606738 @default.
• W2017533384 hasConcept C2781451080 @default.
• W2017533384 hasConcept C31555180 @default.
• W2017533384 hasConcept C43486711 @default.
• W2017533384 hasConcept C62520636 @default.
• W2017533384 hasConcept C66938386 @default.
• W2017533384 hasConcept C71924100 @default.

• next