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• W2017533546 abstract "The spatial topography of amyloid deposition shares similarity with hubs of functional connectivity. The regional hubs of connectivity most vulnerable to Alzheimer's-related disruption reside within the posterior default mode network (pDMN). It has been theorized that high-levels of synaptic activity characteristic of hubs of functional connectivity leads to subsequent beta-amyloid amyloidosis. Therefore, we examined the relationship between baseline functional connectivity in the pDMN in three groups of subjects stratified on longitudinal PiB-PET based amyloid status (stable PiB negative, incident PiB positive, and baseline PiB positive) and a comparison cohort of subjects with Alzheimer's dementia (AD). Cognitively normal (CN) subjects in the Mayo Clinic Study of Aging with 2 or more serial imaging assessments which included adequate quality amyloid PET imaging and task-free fMRI were studied along with a cohort of AD subjects (N=7). The eligible CN subjects were stratified into stable PiB negative (N=63), incident PiB positive (N=20), and baseline PiB positive (N=72). A summary metric of pDMN connectivity was calculated based on a floating dimensionality individual subject independent component analysis with automated network detection. The baseline values for each of the four groups were examined in a one-way ANOVA by group with post-hoc pairwise rank-sum testing. The one-way ANOVA was significant (f = 3.72, p = 0.0127). Baseline pDMN connectivity in incident PiB positive subjects (mean = 1.59 +/- 0.34) was greater than stable PiB negative subjects (p = 0.024, mean = 1.35 +/- 0.47) and AD subjects (p < 0.01, mean = 1.02 +/-0.18), but was not different than baseline PiB positive subjects (p = 0.28, mean = 1.47 +/- 0.44). AD subjects also had less connectivity than the PiB negative group (p = 0.038) and the PiB positive group (p <0.01). No differences in longitudinal change were found. Connectivity increases in the pDMN co-occur with incident amyloid accumulation in CN subjects prior to eventual decline in AD. More study is needed to ascertain whether baseline synaptic activity in hubs of connectivity predispose to amyloidosis, amyloid leads to increased connectivity, or if they are truly co-occurring orthogonal phenomena related to the initiation of the AD pathologic cascade." @default.
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• W2017533546 date "2013-07-01" @default.
• W2017533546 modified "2023-09-27" @default.
• W2017533546 title "O3-03-03: Increased posterior default mode network connectivity co-occurs with incident amyloidosis prior to declining in dementia" @default.
• W2017533546 doi "https://doi.org/10.1016/j.jalz.2013.04.250" @default.
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