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- W2017554966 endingPage "146" @default.
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- W2017554966 abstract "Protease-activated receptor 1 (PAR1) is a G-protein coupled receptor that is expressed throughout the central nervous system. PAR1 activation by brain-derived as well as blood-derived proteases has been shown to have variable and complex effects in a variety of animal models of neuronal injury and inflammation. In this study, we have evaluated the effects of PAR1 on lesion volume in wild-type or PAR1−/− C57Bl/6 mice subjected to transient occlusion of the middle cerebral artery or injected with NMDA in the striatum. We found that removal of PAR1 reduced infarct volume following transient focal ischemia to 57% of control. Removal of PAR1 or application of a PAR1 antagonist also reduced the neuronal injury associated with intrastriatal injection of NMDA to 60% of control. To explore whether NMDA receptor potentiation by PAR1 activation contributes to the harmful effects of PAR1, we investigated the effect of NMDA receptor antagonists on the neuroprotective phenotype of PAR1−/− mice. We found that MK801 reduced penumbral but not core neuronal injury in mice subjected to transient middle cerebral artery occlusion or intrastriatal NMDA injection. Lesion volumes in both models were not significantly different between PAR1−/− mice treated with and without MK801. Use of the NMDA receptor antagonist and dissociative anesthetic ketamine also renders NMDA-induced lesion volumes identical in PAR1−/− mice and wild-type mice. These data suggest that the ability of PAR1 activation to potentiate NMDA receptor function may underlie its harmful actions during injury." @default.
- W2017554966 created "2016-06-24" @default.
- W2017554966 creator A5017733630 @default.
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- W2017554966 creator A5041161550 @default.
- W2017554966 creator A5045736692 @default.
- W2017554966 creator A5059282930 @default.
- W2017554966 date "2009-05-01" @default.
- W2017554966 modified "2023-09-26" @default.
- W2017554966 title "Protease-activated receptor 1-dependent neuronal damage involves NMDA receptor function" @default.
- W2017554966 cites W1463270837 @default.
- W2017554966 cites W1489032270 @default.
- W2017554966 cites W1493941654 @default.
- W2017554966 cites W1561672396 @default.
- W2017554966 cites W1582785412 @default.
- W2017554966 cites W1593687942 @default.
- W2017554966 cites W1594129908 @default.
- W2017554966 cites W1602270034 @default.
- W2017554966 cites W1606744897 @default.
- W2017554966 cites W1613986623 @default.
- W2017554966 cites W1694091762 @default.
- W2017554966 cites W1892378391 @default.
- W2017554966 cites W1898124565 @default.
- W2017554966 cites W1964456661 @default.
- W2017554966 cites W1966751481 @default.
- W2017554966 cites W1970331075 @default.
- W2017554966 cites W1970414529 @default.
- W2017554966 cites W1970747703 @default.
- W2017554966 cites W1973053815 @default.
- W2017554966 cites W1973750046 @default.
- W2017554966 cites W1973816233 @default.
- W2017554966 cites W1979720525 @default.
- W2017554966 cites W1983153323 @default.
- W2017554966 cites W1984674168 @default.
- W2017554966 cites W1987897200 @default.
- W2017554966 cites W1988664274 @default.
- W2017554966 cites W1994653861 @default.
- W2017554966 cites W1995056605 @default.
- W2017554966 cites W1996143722 @default.
- W2017554966 cites W1996618383 @default.
- W2017554966 cites W2003621176 @default.
- W2017554966 cites W2006331624 @default.
- W2017554966 cites W2006395355 @default.
- W2017554966 cites W2007781471 @default.
- W2017554966 cites W2010390902 @default.
- W2017554966 cites W2011841319 @default.
- W2017554966 cites W2011867765 @default.
- W2017554966 cites W2013940987 @default.
- W2017554966 cites W2015642002 @default.
- W2017554966 cites W2020749289 @default.
- W2017554966 cites W2022028909 @default.
- W2017554966 cites W2022278361 @default.
- W2017554966 cites W2025461526 @default.
- W2017554966 cites W2026206201 @default.
- W2017554966 cites W2029323148 @default.
- W2017554966 cites W2030258195 @default.
- W2017554966 cites W2031126076 @default.
- W2017554966 cites W2031574763 @default.
- W2017554966 cites W2032425418 @default.
- W2017554966 cites W2033348257 @default.
- W2017554966 cites W2033437477 @default.
- W2017554966 cites W2037337146 @default.
- W2017554966 cites W2039145424 @default.
- W2017554966 cites W2039497914 @default.
- W2017554966 cites W2041968817 @default.
- W2017554966 cites W2046307134 @default.
- W2017554966 cites W2047859888 @default.
- W2017554966 cites W2049643933 @default.
- W2017554966 cites W2049949557 @default.
- W2017554966 cites W2050039091 @default.
- W2017554966 cites W2050940330 @default.
- W2017554966 cites W2052119252 @default.
- W2017554966 cites W2058353483 @default.
- W2017554966 cites W2058798231 @default.
- W2017554966 cites W2060575534 @default.
- W2017554966 cites W2063908549 @default.
- W2017554966 cites W2064351244 @default.
- W2017554966 cites W2068387849 @default.
- W2017554966 cites W2069252203 @default.
- W2017554966 cites W2071148022 @default.
- W2017554966 cites W2073270002 @default.
- W2017554966 cites W2075276667 @default.
- W2017554966 cites W2076994478 @default.
- W2017554966 cites W2081753893 @default.
- W2017554966 cites W2084552909 @default.
- W2017554966 cites W2085273994 @default.
- W2017554966 cites W2088435955 @default.
- W2017554966 cites W2092102192 @default.
- W2017554966 cites W2092625441 @default.
- W2017554966 cites W2093456571 @default.
- W2017554966 cites W2094960332 @default.
- W2017554966 cites W2099299389 @default.
- W2017554966 cites W2101644805 @default.
- W2017554966 cites W2117406052 @default.
- W2017554966 cites W2118995426 @default.
- W2017554966 cites W2121057211 @default.
- W2017554966 cites W2133658770 @default.
- W2017554966 cites W2136796082 @default.