FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017560394> ?p ?o ?g. }

• W2017560394 endingPage "e0116097" @default.
• W2017560394 startingPage "e0116097" @default.
• W2017560394 abstract "Olfactory receptor (OR)-associated events are mediated by well-conserved components in the olfactory epithelium, including olfactory G-protein (Golf), adenylate cyclase III (ACIII), and olfactory marker protein (OMP). The expression of ORs has recently been observed in non-olfactory tissues where they are involved in monitoring extracellular chemical cues. The large number of OR genes and their sequence similarities illustrate the need to find an effective and simple way to detect non-olfactory OR-associated events. In addition, expression profiles and physiological functions of ORs in non-olfactory tissues are largely unknown. To overcome limitations associated with using OR as a target protein, this study used OMP with Golf and ACIII as targets to screen for potential OR-mediated sensing systems in non-olfactory tissues. Here, we show using western blotting, real-time PCR, and single as well as double immunoassays that ORs and OR-associated proteins are co-expressed in diverse tissues. The results of immunohistochemical analyses showed OMP (+) cells in mouse heart and in the following cells using the corresponding marker proteins c-kit, keratin 14, calcitonin, and GFAP in mouse tissues: interstitial cells of Cajal of the bladder, medullary thymic epithelial cells of the thymus, parafollicular cells of the thyroid, and Leydig cells of the testis. The expression of ORs in OMP (+) tissues was analyzed using a refined microarray analysis and validated with RT-PCR and real-time PCR. Three ORs (olfr544, olfr558, and olfr1386) were expressed in the OMP (+) cells of the bladder and thyroid as shown using a co-immunostaining method. Together, these results suggest that OMP is involved in the OR-mediated signal transduction cascade with olfactory canonical signaling components between the nervous and endocrine systems. The results further demonstrate that OMP immunohistochemical analysis is a useful tool for identifying expression of ORs, suggesting OMP expression is an indicator of potential OR-mediated chemoreception in non-olfactory systems." @default.
• W2017560394 created "2016-06-24" @default.
• W2017560394 creator A5002821815 @default.
• W2017560394 creator A5009576538 @default.
• W2017560394 creator A5020223360 @default.
• W2017560394 creator A5028070594 @default.
• W2017560394 creator A5038196805 @default.
• W2017560394 creator A5040973387 @default.
• W2017560394 creator A5059898659 @default.
• W2017560394 creator A5066053205 @default.
• W2017560394 creator A5077800857 @default.
• W2017560394 creator A5084705966 @default.
• W2017560394 date "2015-01-30" @default.
• W2017560394 modified "2023-10-18" @default.
• W2017560394 title "Olfactory Marker Protein Expression Is an Indicator of Olfactory Receptor-Associated Events in Non-Olfactory Tissues" @default.
• W2017560394 cites W105976332 @default.
• W2017560394 cites W1483715699 @default.
• W2017560394 cites W1504482130 @default.
• W2017560394 cites W1558002500 @default.
• W2017560394 cites W1603858169 @default.
• W2017560394 cites W1822784852 @default.
• W2017560394 cites W191842860 @default.
• W2017560394 cites W1976268224 @default.
• W2017560394 cites W1980199676 @default.
• W2017560394 cites W1980317750 @default.
• W2017560394 cites W1982955132 @default.
• W2017560394 cites W1983646382 @default.
• W2017560394 cites W1985966332 @default.
• W2017560394 cites W1990374554 @default.
• W2017560394 cites W1992625828 @default.
• W2017560394 cites W1994863439 @default.
• W2017560394 cites W1996647995 @default.
• W2017560394 cites W1997825411 @default.
• W2017560394 cites W2000574570 @default.
• W2017560394 cites W2011767107 @default.
• W2017560394 cites W2011910373 @default.
• W2017560394 cites W2017741795 @default.
• W2017560394 cites W2018825127 @default.
• W2017560394 cites W2019121484 @default.
• W2017560394 cites W2022049021 @default.
• W2017560394 cites W2022756254 @default.
• W2017560394 cites W2023029854 @default.
• W2017560394 cites W2028112942 @default.
• W2017560394 cites W2033763537 @default.
• W2017560394 cites W2042381148 @default.
• W2017560394 cites W2042791996 @default.
• W2017560394 cites W2044846185 @default.
• W2017560394 cites W2047458612 @default.
• W2017560394 cites W2048091014 @default.
• W2017560394 cites W2049176073 @default.
• W2017560394 cites W2053324328 @default.
• W2017560394 cites W2067449016 @default.
• W2017560394 cites W2072248036 @default.
• W2017560394 cites W2074467596 @default.
• W2017560394 cites W2076249483 @default.
• W2017560394 cites W2089193539 @default.
• W2017560394 cites W2089269195 @default.
• W2017560394 cites W2093826299 @default.
• W2017560394 cites W2094453861 @default.
• W2017560394 cites W2096037842 @default.
• W2017560394 cites W2097186487 @default.
• W2017560394 cites W2097404580 @default.
• W2017560394 cites W2101091917 @default.
• W2017560394 cites W2117737982 @default.
• W2017560394 cites W2119139928 @default.
• W2017560394 cites W2130867082 @default.
• W2017560394 cites W2133831748 @default.
• W2017560394 cites W2138777912 @default.
• W2017560394 cites W2147678627 @default.
• W2017560394 cites W2147771024 @default.
• W2017560394 cites W2152503927 @default.
• W2017560394 cites W2155165511 @default.
• W2017560394 cites W2155217980 @default.
• W2017560394 cites W2161659751 @default.
• W2017560394 cites W2164101639 @default.
• W2017560394 cites W2164683872 @default.
• W2017560394 cites W2164760852 @default.
• W2017560394 cites W2165840505 @default.
• W2017560394 cites W2166964306 @default.
• W2017560394 cites W2317586011 @default.
• W2017560394 cites W4205298449 @default.
• W2017560394 cites W4253331630 @default.
• W2017560394 doi "https://doi.org/10.1371/journal.pone.0116097" @default.
• W2017560394 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4311928" @default.
• W2017560394 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25635859" @default.
• W2017560394 hasPublicationYear "2015" @default.
• W2017560394 type Work @default.
• W2017560394 sameAs 2017560394 @default.
• W2017560394 citedByCount "49" @default.
• W2017560394 countsByYear W20175603942015 @default.
• W2017560394 countsByYear W20175603942016 @default.
• W2017560394 countsByYear W20175603942017 @default.
• W2017560394 countsByYear W20175603942018 @default.
• W2017560394 countsByYear W20175603942019 @default.
• W2017560394 countsByYear W20175603942020 @default.
• W2017560394 countsByYear W20175603942021 @default.
• W2017560394 countsByYear W20175603942022 @default.
• W2017560394 countsByYear W20175603942023 @default.

• next