FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017564963> ?p ?o ?g. }

• W2017564963 endingPage "1805" @default.
• W2017564963 startingPage "1797" @default.
• W2017564963 abstract "Aristolochia species are nephrotoxic and carcinogenic. Recent studies showed that aristolochic acid (AA) could induce acute renal failure and tubular lesions in several species and available evidences demonstrate the unequivocal role of AA in so called Chinese herbs nephropathy.A series of AA derivatives isolated from Aristolochia spp. were analyzed for their nephrotoxic potential using the neutral red dye exclusion assay in cultures of LLC-PK(1) cells. The structural relationships between AA I and its analogues were compared with their cytotoxic effects to predict structural determinants for AA toxicity. Further, caspase-3 assay was performed on toxic compounds to determine if caspases, the enzymes that play a critical role in apoptosis are involved in AA-induced cytotoxicity.AA I was found to be most toxic followed by AA II, AA VIIIa, and AA Ia in decreasing levels of toxicity. The other compounds, nitrophenanthrene carboxylic acid analogues of AA I, aristolactams, and other derivatives did not exhibit considerable toxicity. The results showed significant relationships between cytotoxicity of AA compounds and the localization of functional groups in their structure. Analogues containing hydroxyl groups diminished cytotoxicity. The demethylated analogues of AA I are markedly less active. The negative impact on cytotoxicity was found on nitroreduction of AA I. AA induced caspase activation was also observed.These cytotoxic data suggest that the nitro and methoxy groups are critical determinants of nephrotoxicologic potency of AA." @default.
• W2017564963 created "2016-06-24" @default.
• W2017564963 creator A5037571653 @default.
• W2017564963 creator A5041998468 @default.
• W2017564963 creator A5042249930 @default.
• W2017564963 creator A5049082763 @default.
• W2017564963 creator A5066969749 @default.
• W2017564963 date "2005-05-01" @default.
• W2017564963 modified "2023-10-10" @default.
• W2017564963 title "Structure activity relationships of aristolochic acid analogues: Toxicity in cultured renal epithelial cells" @default.
• W2017564963 cites W1493318691 @default.
• W2017564963 cites W1506642042 @default.
• W2017564963 cites W1558440964 @default.
• W2017564963 cites W1942214720 @default.
• W2017564963 cites W1963762846 @default.
• W2017564963 cites W1977568986 @default.
• W2017564963 cites W1980205917 @default.
• W2017564963 cites W1987133019 @default.
• W2017564963 cites W1989819465 @default.
• W2017564963 cites W2000053786 @default.
• W2017564963 cites W2001364126 @default.
• W2017564963 cites W2005753849 @default.
• W2017564963 cites W2012930726 @default.
• W2017564963 cites W2013329829 @default.
• W2017564963 cites W2017107068 @default.
• W2017564963 cites W2018086514 @default.
• W2017564963 cites W2021280906 @default.
• W2017564963 cites W2025173817 @default.
• W2017564963 cites W2027543129 @default.
• W2017564963 cites W2027621465 @default.
• W2017564963 cites W2029483765 @default.
• W2017564963 cites W2037673603 @default.
• W2017564963 cites W2045318949 @default.
• W2017564963 cites W2047244088 @default.
• W2017564963 cites W2056217256 @default.
• W2017564963 cites W2056913196 @default.
• W2017564963 cites W2061497413 @default.
• W2017564963 cites W2073347694 @default.
• W2017564963 cites W2075030980 @default.
• W2017564963 cites W2076513375 @default.
• W2017564963 cites W2077122464 @default.
• W2017564963 cites W2078106903 @default.
• W2017564963 cites W2083150338 @default.
• W2017564963 cites W2087140055 @default.
• W2017564963 cites W2087463240 @default.
• W2017564963 cites W2088686339 @default.
• W2017564963 cites W2090024127 @default.
• W2017564963 cites W2090093965 @default.
• W2017564963 cites W2096972124 @default.
• W2017564963 cites W2098170884 @default.
• W2017564963 cites W2111268058 @default.
• W2017564963 cites W2120221084 @default.
• W2017564963 cites W2155379255 @default.
• W2017564963 cites W2162463986 @default.
• W2017564963 cites W2325707043 @default.
• W2017564963 cites W2735195239 @default.
• W2017564963 cites W3142714722 @default.
• W2017564963 cites W47860904 @default.
• W2017564963 doi "https://doi.org/10.1111/j.1523-1755.2005.00277.x" @default.
• W2017564963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15840026" @default.
• W2017564963 hasPublicationYear "2005" @default.
• W2017564963 type Work @default.
• W2017564963 sameAs 2017564963 @default.
• W2017564963 citedByCount "151" @default.
• W2017564963 countsByYear W20175649632012 @default.
• W2017564963 countsByYear W20175649632013 @default.
• W2017564963 countsByYear W20175649632014 @default.
• W2017564963 countsByYear W20175649632015 @default.
• W2017564963 countsByYear W20175649632016 @default.
• W2017564963 countsByYear W20175649632017 @default.
• W2017564963 countsByYear W20175649632018 @default.
• W2017564963 countsByYear W20175649632019 @default.
• W2017564963 countsByYear W20175649632020 @default.
• W2017564963 countsByYear W20175649632021 @default.
• W2017564963 countsByYear W20175649632022 @default.
• W2017564963 countsByYear W20175649632023 @default.
• W2017564963 crossrefType "journal-article" @default.
• W2017564963 hasAuthorship W2017564963A5037571653 @default.
• W2017564963 hasAuthorship W2017564963A5041998468 @default.
• W2017564963 hasAuthorship W2017564963A5042249930 @default.
• W2017564963 hasAuthorship W2017564963A5049082763 @default.
• W2017564963 hasAuthorship W2017564963A5066969749 @default.
• W2017564963 hasBestOaLocation W20175649631 @default.
• W2017564963 hasConcept C109316439 @default.
• W2017564963 hasConcept C114246631 @default.
• W2017564963 hasConcept C126189478 @default.
• W2017564963 hasConcept C134018914 @default.
• W2017564963 hasConcept C178790620 @default.
• W2017564963 hasConcept C185592680 @default.
• W2017564963 hasConcept C190283241 @default.
• W2017564963 hasConcept C202751555 @default.
• W2017564963 hasConcept C2780091579 @default.
• W2017564963 hasConcept C2780813843 @default.
• W2017564963 hasConcept C29730261 @default.
• W2017564963 hasConcept C31573885 @default.
• W2017564963 hasConcept C54355233 @default.
• W2017564963 hasConcept C55493867 @default.
• W2017564963 hasConcept C71240020 @default.

• next