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- W2017567981 abstract "Abstract The translocation of a single macromolecule through a protein pore or a solid-state nanopore involves three major stages: (1) approach of the macromolecule towards the pore, (2) capture/recognition of the macromolecule at the pore entrance, and (3) threading through the pore (see the Figure) (Muthukumar, 2011). All of these stages are controlled by conformational entropy of the macromolecule, charge decoration, and the geometry of the pore, hydrodynamics, and electrostatic interactions. Chief among the contributing factors are the entropic barrier presented by the pore to the penetration of the macromolecule, pore–polymer interactions, electro-osmotic flow, and the drift-diffusion of the macromolecule in electrolyte solutions. A unifying theory of these contributing factors will be described in the context of a few illustrative experimental data on DNA translocation and protein translocation through protein pores and solid-state nanopores. Future challenges to specific biological systems will be briefly discussed." @default.
- W2017567981 created "2016-06-24" @default.
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- W2017567981 date "2013-01-01" @default.
- W2017567981 modified "2023-09-23" @default.
- W2017567981 title "204 Polymer translocation" @default.
- W2017567981 doi "https://doi.org/10.1080/07391102.2013.786447" @default.
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