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- W2017570129 abstract "16α, 18-Dihydroxydeoxycorticosterone (16α, 18-dihydroxy-DOC) (1)and 1, 2-3H-16α, 18-dihydroxy-DOC (1,2-3H-16α, 18-dihydroxy-DOC) of high specific activity were obtained in good yield by microbiological hydroxylation of 18-OH-DOC and 1,2-3H-18-OH-DOC by Streptomyces roseochromogenus (ATCC 13400). The identity of the fermentation product to human adrenal produced 16α, 18-dihy-droxy-DOC was established by Chromatographic studies, derivative formation and gas-liquid chromatography. Yield of the product was about 30% of substrate and allowing for losses in recovery, about 60% of the substrate 18-OH-DOC was converted to this product. A second product of fermentation isolated in lower yield appeared to be a dimer of 16α, 18-dihydroxy-DOC found in the acidic conditions of the fermentation. This method of synthesis of 16α, 18-dihydroxy-DOC is a practical way to make large quantities of the compound for further study of its possible role in human and experimental hypertension." @default.
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- W2017570129 date "1975-12-01" @default.
- W2017570129 modified "2023-09-25" @default.
- W2017570129 title "Microbiological synthesis of 16α, 18-dihydroxydeoxycorticosterone" @default.
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- W2017570129 doi "https://doi.org/10.1016/0039-128x(75)90103-8" @default.
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