FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017573156> ?p ?o ?g. }

• W2017573156 endingPage "73" @default.
• W2017573156 startingPage "67" @default.
• W2017573156 abstract "Cell-penetrating peptides (CPPs) have been widely used to enhance the membrane translocation of various carriers for many years, but the non-specificity of CPPs seriously limits their utility in vivo. In this study, cholesterol-anchored, reduction-sensitive PEG (first synthesized by our laboratory) was applied to develop a co-modified liposome with improved tumor targeting. Following optimization of the formulation, the in vitro and in vivo properties of the co-modified liposome were evaluated. The co-modified liposome had a much lower cellular uptake and tumor spheroid uptake, but a much higher tumor accumulation compared to CPP-modified liposome, indicating the non-specific penetration of CPPs could be attenuated by the outer PEG coating. With the addition of exogenous reducing agent, both the in vitro and in vivo cellular uptake was markedly increased, demonstrating that the reduction-sensitive PEG coating achieved a controllable detachment from the surface of liposomes and did not affect the penetrating abilities of CPPs. The present results demonstrate that the combination of cholestervsitive PEG and CPPs is an ideal alternative for the application of CPP-modified carriers in vivo." @default.
• W2017573156 created "2016-06-24" @default.
• W2017573156 creator A5001421484 @default.
• W2017573156 creator A5008235859 @default.
• W2017573156 creator A5012427149 @default.
• W2017573156 creator A5026174200 @default.
• W2017573156 creator A5034676524 @default.
• W2017573156 creator A5066716873 @default.
• W2017573156 creator A5088172945 @default.
• W2017573156 date "2014-02-01" @default.
• W2017573156 modified "2023-10-06" @default.
• W2017573156 title "A detachable coating of cholesterol-anchored PEG improves tumor targeting of cell-penetrating peptide-modified liposomes" @default.
• W2017573156 cites W1979993551 @default.
• W2017573156 cites W1983486105 @default.
• W2017573156 cites W1990455420 @default.
• W2017573156 cites W1991720510 @default.
• W2017573156 cites W2005364323 @default.
• W2017573156 cites W2006795600 @default.
• W2017573156 cites W2008576706 @default.
• W2017573156 cites W2015202374 @default.
• W2017573156 cites W2017111116 @default.
• W2017573156 cites W2024164406 @default.
• W2017573156 cites W2026755460 @default.
• W2017573156 cites W2036811391 @default.
• W2017573156 cites W2041759339 @default.
• W2017573156 cites W2044417412 @default.
• W2017573156 cites W2052606768 @default.
• W2017573156 cites W2052758340 @default.
• W2017573156 cites W2056252055 @default.
• W2017573156 cites W2056493684 @default.
• W2017573156 cites W2063396729 @default.
• W2017573156 cites W2072581984 @default.
• W2017573156 cites W2082511916 @default.
• W2017573156 cites W2102187303 @default.
• W2017573156 cites W2115824449 @default.
• W2017573156 cites W2145962904 @default.
• W2017573156 cites W2164288350 @default.
• W2017573156 cites W2320970377 @default.
• W2017573156 cites W2331711315 @default.
• W2017573156 cites W2413347875 @default.
• W2017573156 doi "https://doi.org/10.1016/j.apsb.2013.12.004" @default.
• W2017573156 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4590295" @default.
• W2017573156 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26579366" @default.
• W2017573156 hasPublicationYear "2014" @default.
• W2017573156 type Work @default.
• W2017573156 sameAs 2017573156 @default.
• W2017573156 citedByCount "20" @default.
• W2017573156 countsByYear W20175731562014 @default.
• W2017573156 countsByYear W20175731562015 @default.
• W2017573156 countsByYear W20175731562016 @default.
• W2017573156 countsByYear W20175731562017 @default.
• W2017573156 countsByYear W20175731562018 @default.
• W2017573156 countsByYear W20175731562019 @default.
• W2017573156 countsByYear W20175731562020 @default.
• W2017573156 countsByYear W20175731562021 @default.
• W2017573156 countsByYear W20175731562022 @default.
• W2017573156 countsByYear W20175731562023 @default.
• W2017573156 crossrefType "journal-article" @default.
• W2017573156 hasAuthorship W2017573156A5001421484 @default.
• W2017573156 hasAuthorship W2017573156A5008235859 @default.
• W2017573156 hasAuthorship W2017573156A5012427149 @default.
• W2017573156 hasAuthorship W2017573156A5026174200 @default.
• W2017573156 hasAuthorship W2017573156A5034676524 @default.
• W2017573156 hasAuthorship W2017573156A5066716873 @default.
• W2017573156 hasAuthorship W2017573156A5088172945 @default.
• W2017573156 hasBestOaLocation W20175731561 @default.
• W2017573156 hasConcept C10138342 @default.
• W2017573156 hasConcept C12554922 @default.
• W2017573156 hasConcept C127413603 @default.
• W2017573156 hasConcept C1491633281 @default.
• W2017573156 hasConcept C150903083 @default.
• W2017573156 hasConcept C162324750 @default.
• W2017573156 hasConcept C185154212 @default.
• W2017573156 hasConcept C185592680 @default.
• W2017573156 hasConcept C202751555 @default.
• W2017573156 hasConcept C207001950 @default.
• W2017573156 hasConcept C2776929087 @default.
• W2017573156 hasConcept C2779281246 @default.
• W2017573156 hasConcept C42475967 @default.
• W2017573156 hasConcept C54400483 @default.
• W2017573156 hasConcept C55493867 @default.
• W2017573156 hasConcept C80107235 @default.
• W2017573156 hasConcept C86803240 @default.
• W2017573156 hasConceptScore W2017573156C10138342 @default.
• W2017573156 hasConceptScore W2017573156C12554922 @default.
• W2017573156 hasConceptScore W2017573156C127413603 @default.
• W2017573156 hasConceptScore W2017573156C1491633281 @default.
• W2017573156 hasConceptScore W2017573156C150903083 @default.
• W2017573156 hasConceptScore W2017573156C162324750 @default.
• W2017573156 hasConceptScore W2017573156C185154212 @default.
• W2017573156 hasConceptScore W2017573156C185592680 @default.
• W2017573156 hasConceptScore W2017573156C202751555 @default.
• W2017573156 hasConceptScore W2017573156C207001950 @default.
• W2017573156 hasConceptScore W2017573156C2776929087 @default.
• W2017573156 hasConceptScore W2017573156C2779281246 @default.
• W2017573156 hasConceptScore W2017573156C42475967 @default.
• W2017573156 hasConceptScore W2017573156C54400483 @default.
• W2017573156 hasConceptScore W2017573156C55493867 @default.

• next