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- W2017573188 abstract "Treatment of human B lymphocytes with an optimal concentration of okadaic acid, an inhibitor of phosphatases 1 and 2A, resulted in the induction of the transcription factor, AP-1 and a marked increase in NF-κB levels. In contrast, no effect on the levels of the octamer binding proteins, Oct-1 or Oct-2, were found. Since both AP-1 and NF-κB have been reported to be important in the induction of the tumor necrosis factor-α (TNF-α) gene we examined the effects of okadaic acid on TNF-α mRNA levels. Treatment with okadaic acid resulted in a striking increase in TNF-α mRNA transcripts within 1 h of stimulation and large amounts of TNF-α were released into the culture media. Although okadaic acid provides a potent inductive signal for AP-1 and NF-κB it did not induce either B cell proliferation or immunoglobulin secretion." @default.
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- W2017573188 date "1992-08-01" @default.
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- W2017573188 title "Okadaic acid is a potent inducer of AP-1, NF-κB, and tumor necrosis factor-α in human B lymphocytes" @default.
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- W2017573188 doi "https://doi.org/10.1016/s0006-291x(05)81457-3" @default.
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