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- W2017573713 abstract "The role of Group X secreted phospholipase A2 (GX-sPLA2) during influenza infection has not been previously investigated. We examined the role of GX-sPLA2 during H1N1 pandemic influenza infection in a GX-sPLA2 gene targeted mouse (GX(-/-)) model and found that survival after infection was significantly greater in GX(-/-) mice than in GX(+/+) mice. Downstream products of GX-sPLA2 activity, PGD2, PGE2, LTB4, cysteinyl leukotrienes and Lipoxin A4 were significantly lower in GX(-/-) mice BAL fluid. Lung microarray analysis identified an earlier and more robust induction of T and B cell associated genes in GX(-/-) mice. Based on the central role of sPLA2 enzymes as key initiators of inflammatory processes, we propose that activation of GX-sPLA2 during H1N1pdm infection is an early step of pulmonary inflammation and its inhibition increases adaptive immunity and improves survival. Our findings suggest that GX-sPLA2 may be a potential therapeutic target during influenza." @default.
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- W2017573713 date "2014-04-01" @default.
- W2017573713 modified "2023-10-18" @default.
- W2017573713 title "Lack of group X secreted phospholipase A2 increases survival following pandemic H1N1 influenza infection" @default.
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- W2017573713 doi "https://doi.org/10.1016/j.virol.2014.01.030" @default.
- W2017573713 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4106042" @default.
- W2017573713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24725934" @default.
- W2017573713 hasPublicationYear "2014" @default.
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