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- W2017574303 abstract "Combined non-linear imaging techniques were used to deeply image human ex-vivo fresh biopsies of bladder as well as to discriminate between healthy bladder mucosa and carcinoma in situ. Morphological examination by two-photon excited fluorescence and second-harmonic generation has shown a good agreement with corresponding common routine histology performed on the same samples. Tumor cells appeared slightly different in shape and with a smaller cellular-to-nuclear dimension ratio with respect to corresponding normal cells. Further differences between the two tissue types were found in both spectral emission and fluorescence lifetime distribution by performing temporal- and spectral- resolved analysis of fluorescence. This method may represent a promising tool to be used in a multi-photon endoscope, in a confocal endoscope or in a spectroscopic probe for in-vivo optical diagnosis of bladder cancer." @default.
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- W2017574303 date "2010-02-11" @default.
- W2017574303 modified "2023-09-27" @default.
- W2017574303 title "Time- and Spectral-resolved two-photon imaging of healthy bladder mucosa and carcinoma in situ" @default.
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- W2017574303 doi "https://doi.org/10.1364/oe.18.003840" @default.
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