Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017576295> ?p ?o ?g. }
- W2017576295 endingPage "7843" @default.
- W2017576295 startingPage "7836" @default.
- W2017576295 abstract "ABSTRACT We developed a method for simultaneous in vivo biophotonic monitoring of pneumococcal meningitis and the accompanying neuronal injury in live transgenic mice. Streptococcus pneumoniae engineered for bioluminescence ( lux ) was used for direct visualization of disease progression and antibiotic treatment in a mouse model of meningitis. The host response was monitored in transgenic mice containing an inducible firefly luciferase ( luc ) reporter gene under transcriptional control of the mouse glial fibrillary acidic protein (GFAP) promoter. Based on the different spectra of light emission and substrate requirements for lux and luc , we were able to separately monitor the two reporters using a highly sensitive in vivo imaging system. The level of neuronal damage and recovery following antibiotic treatment was dependent on the time of treatment. This model has potential for simultaneous multiparameter monitoring and testing of therapies that target the pathogen or host response to prevent neuronal injury and recovery." @default.
- W2017576295 created "2016-06-24" @default.
- W2017576295 creator A5004001758 @default.
- W2017576295 creator A5018740859 @default.
- W2017576295 creator A5019700261 @default.
- W2017576295 creator A5048372736 @default.
- W2017576295 creator A5064403854 @default.
- W2017576295 creator A5068460396 @default.
- W2017576295 creator A5090196971 @default.
- W2017576295 date "2005-12-01" @default.
- W2017576295 modified "2023-10-16" @default.
- W2017576295 title "Reduction of Astrogliosis by Early Treatment of Pneumococcal Meningitis Measured by Simultaneous Imaging, In Vivo, of the Pathogen and Host Response" @default.
- W2017576295 cites W141378801 @default.
- W2017576295 cites W1628803889 @default.
- W2017576295 cites W1632755291 @default.
- W2017576295 cites W1968766467 @default.
- W2017576295 cites W1971668430 @default.
- W2017576295 cites W1973896986 @default.
- W2017576295 cites W1975663198 @default.
- W2017576295 cites W1986919536 @default.
- W2017576295 cites W1998026338 @default.
- W2017576295 cites W2018061597 @default.
- W2017576295 cites W2027623966 @default.
- W2017576295 cites W2036575802 @default.
- W2017576295 cites W2044176417 @default.
- W2017576295 cites W205382369 @default.
- W2017576295 cites W2056637173 @default.
- W2017576295 cites W2058543429 @default.
- W2017576295 cites W2063119860 @default.
- W2017576295 cites W2074328191 @default.
- W2017576295 cites W2083204774 @default.
- W2017576295 cites W2085485753 @default.
- W2017576295 cites W2088047284 @default.
- W2017576295 cites W2098222530 @default.
- W2017576295 cites W2106820870 @default.
- W2017576295 cites W2113546972 @default.
- W2017576295 cites W2119507443 @default.
- W2017576295 cites W2130804040 @default.
- W2017576295 cites W2131312457 @default.
- W2017576295 cites W2136343619 @default.
- W2017576295 cites W2143176654 @default.
- W2017576295 cites W2145453264 @default.
- W2017576295 cites W2160128724 @default.
- W2017576295 cites W2170405846 @default.
- W2017576295 cites W2184701648 @default.
- W2017576295 cites W2323123959 @default.
- W2017576295 cites W2328097252 @default.
- W2017576295 cites W2397148218 @default.
- W2017576295 cites W2789870354 @default.
- W2017576295 cites W3176341528 @default.
- W2017576295 cites W4252077510 @default.
- W2017576295 doi "https://doi.org/10.1128/iai.73.12.7836-7843.2005" @default.
- W2017576295 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1307043" @default.
- W2017576295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16299273" @default.
- W2017576295 hasPublicationYear "2005" @default.
- W2017576295 type Work @default.
- W2017576295 sameAs 2017576295 @default.
- W2017576295 citedByCount "56" @default.
- W2017576295 countsByYear W20175762952012 @default.
- W2017576295 countsByYear W20175762952013 @default.
- W2017576295 countsByYear W20175762952014 @default.
- W2017576295 countsByYear W20175762952015 @default.
- W2017576295 countsByYear W20175762952016 @default.
- W2017576295 countsByYear W20175762952017 @default.
- W2017576295 countsByYear W20175762952019 @default.
- W2017576295 countsByYear W20175762952021 @default.
- W2017576295 crossrefType "journal-article" @default.
- W2017576295 hasAuthorship W2017576295A5004001758 @default.
- W2017576295 hasAuthorship W2017576295A5018740859 @default.
- W2017576295 hasAuthorship W2017576295A5019700261 @default.
- W2017576295 hasAuthorship W2017576295A5048372736 @default.
- W2017576295 hasAuthorship W2017576295A5064403854 @default.
- W2017576295 hasAuthorship W2017576295A5068460396 @default.
- W2017576295 hasAuthorship W2017576295A5090196971 @default.
- W2017576295 hasBestOaLocation W20175762951 @default.
- W2017576295 hasConcept C102230213 @default.
- W2017576295 hasConcept C104317684 @default.
- W2017576295 hasConcept C111335760 @default.
- W2017576295 hasConcept C118552586 @default.
- W2017576295 hasConcept C150903083 @default.
- W2017576295 hasConcept C161997846 @default.
- W2017576295 hasConcept C169760540 @default.
- W2017576295 hasConcept C207001950 @default.
- W2017576295 hasConcept C2776460866 @default.
- W2017576295 hasConcept C2779965356 @default.
- W2017576295 hasConcept C2781026528 @default.
- W2017576295 hasConcept C2781253189 @default.
- W2017576295 hasConcept C501593827 @default.
- W2017576295 hasConcept C5176359 @default.
- W2017576295 hasConcept C529278444 @default.
- W2017576295 hasConcept C54009773 @default.
- W2017576295 hasConcept C55493867 @default.
- W2017576295 hasConcept C71924100 @default.
- W2017576295 hasConcept C86803240 @default.
- W2017576295 hasConcept C89423630 @default.
- W2017576295 hasConceptScore W2017576295C102230213 @default.
- W2017576295 hasConceptScore W2017576295C104317684 @default.
- W2017576295 hasConceptScore W2017576295C111335760 @default.