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- W2017576872 abstract "Pulmonary immunization has gained increased recognition as a means of triggering both a mucosal and systemic immune response without the use of needles. The appropriate formulation of antigens in a dry, solid state can result in improved stability, thereby removing cold-chain storage complications associated with conventional liquid-based vaccines. The particulate nature of dry powder vaccines could also induce a better immune response. This review describes our current understanding of pulmonary immunization, including possible barriers facing the development of pulmonary vaccines, and discusses recent advances in spray-drying technologies applicable to the production of dry powder formulations for pulmonary vaccine delivery. Pulmonary immunization has gained increased recognition as a means of triggering both a mucosal and systemic immune response without the use of needles. The appropriate formulation of antigens in a dry, solid state can result in improved stability, thereby removing cold-chain storage complications associated with conventional liquid-based vaccines. The particulate nature of dry powder vaccines could also induce a better immune response. This review describes our current understanding of pulmonary immunization, including possible barriers facing the development of pulmonary vaccines, and discusses recent advances in spray-drying technologies applicable to the production of dry powder formulations for pulmonary vaccine delivery." @default.
- W2017576872 created "2016-06-24" @default.
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- W2017576872 date "2011-04-01" @default.
- W2017576872 modified "2023-10-18" @default.
- W2017576872 title "New developments in dry powder pulmonary vaccine delivery" @default.
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- W2017576872 doi "https://doi.org/10.1016/j.tibtech.2010.12.009" @default.
- W2017576872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21255854" @default.
- W2017576872 hasPublicationYear "2011" @default.
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