FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017577437> ?p ?o ?g. }

• W2017577437 endingPage "459" @default.
• W2017577437 startingPage "447" @default.
• W2017577437 abstract "Abstract Background: Genotyping is crucial for the identification of genetic markers underlying the development of neoplastic diseases and for determining individual variations in response to specific drugs. Technologies which can accurately identify genetic polymorphisms will dramatically affect routine diagnostic processes and future therapeutic developments in personalized medicine. However, such methods need to fulfill the principles of analytical validation to determine their suitability to assess nucleotide polymorphisms in target genes. Approach: This article reviews recent developments in homogeneous technologies for the genotyping of single nucleotide polymorphisms. Here, homogeneous methods essentially refer to “single-tube” assays performed in a liquid phase. For the appropriate choice of any method, several criteria must be considered: 1) detection of known genetic variations; 2) analytical performance including specificity, sensitivity and robustness of the method; 3) availability of large platforms and required equipment; 4) suitability of platforms and tests for routine diagnostics; 5) suitability for high throughput implementation. Content: This review is intended to provide the reader with an understanding of these various technologies for pharmacogenomic testing in the routine clinical laboratory. A brief overview is provided on the available technologies for the detection of known mutations, a specific description of the homogeneous platforms currently employed in genotyping analysis, and considerations regarding the proper assessment of the analytical performance of these methods. Based on the criteria proposed here, potential users may evaluate advantages and limitations of the various analytical platforms and identify the most appropriate platform according to their specific setting and diagnostic needs. Clin Chem Lab Med 2010;48:447–59." @default.
• W2017577437 created "2016-06-24" @default.
• W2017577437 creator A5015452702 @default.
• W2017577437 creator A5033029228 @default.
• W2017577437 creator A5049075689 @default.
• W2017577437 creator A5062904109 @default.
• W2017577437 creator A5067570459 @default.
• W2017577437 creator A5077919557 @default.
• W2017577437 creator A5084022811 @default.
• W2017577437 date "2010-03-02" @default.
• W2017577437 modified "2023-09-26" @default.
• W2017577437 title "Decision criteria for rational selection of homogeneous genotyping platforms for pharmacogenomics testing in clinical diagnostics" @default.
• W2017577437 cites W1494059827 @default.
• W2017577437 cites W1967103850 @default.
• W2017577437 cites W1968217876 @default.
• W2017577437 cites W1970586100 @default.
• W2017577437 cites W1972210186 @default.
• W2017577437 cites W1976526513 @default.
• W2017577437 cites W1977688366 @default.
• W2017577437 cites W1983156982 @default.
• W2017577437 cites W1992222472 @default.
• W2017577437 cites W1998175281 @default.
• W2017577437 cites W1999336249 @default.
• W2017577437 cites W2000903198 @default.
• W2017577437 cites W2002076894 @default.
• W2017577437 cites W2003798531 @default.
• W2017577437 cites W2003984225 @default.
• W2017577437 cites W2005068724 @default.
• W2017577437 cites W2006998980 @default.
• W2017577437 cites W2012711528 @default.
• W2017577437 cites W2014523793 @default.
• W2017577437 cites W2014722248 @default.
• W2017577437 cites W2015714093 @default.
• W2017577437 cites W2020478095 @default.
• W2017577437 cites W2023398477 @default.
• W2017577437 cites W2029035130 @default.
• W2017577437 cites W2030975106 @default.
• W2017577437 cites W2045133417 @default.
• W2017577437 cites W2055842728 @default.
• W2017577437 cites W2062253025 @default.
• W2017577437 cites W2068196801 @default.
• W2017577437 cites W2072513435 @default.
• W2017577437 cites W2072769826 @default.
• W2017577437 cites W2074435495 @default.
• W2017577437 cites W2075264134 @default.
• W2017577437 cites W2084848615 @default.
• W2017577437 cites W2094444865 @default.
• W2017577437 cites W2095097110 @default.
• W2017577437 cites W2098442878 @default.
• W2017577437 cites W2099851544 @default.
• W2017577437 cites W2103843703 @default.
• W2017577437 cites W2108524851 @default.
• W2017577437 cites W2116475785 @default.
• W2017577437 cites W2119478462 @default.
• W2017577437 cites W2123717662 @default.
• W2017577437 cites W2129455456 @default.
• W2017577437 cites W2133940490 @default.
• W2017577437 cites W2152764077 @default.
• W2017577437 cites W2153275427 @default.
• W2017577437 cites W2163636362 @default.
• W2017577437 cites W2166335627 @default.
• W2017577437 cites W2166811291 @default.
• W2017577437 cites W2167372325 @default.
• W2017577437 cites W3022064903 @default.
• W2017577437 cites W4241530587 @default.
• W2017577437 doi "https://doi.org/10.1515/cclm.2010.112" @default.
• W2017577437 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20192881" @default.
• W2017577437 hasPublicationYear "2010" @default.
• W2017577437 type Work @default.
• W2017577437 sameAs 2017577437 @default.
• W2017577437 citedByCount "19" @default.
• W2017577437 countsByYear W20175774372012 @default.
• W2017577437 countsByYear W20175774372014 @default.
• W2017577437 countsByYear W20175774372016 @default.
• W2017577437 countsByYear W20175774372017 @default.
• W2017577437 countsByYear W20175774372018 @default.
• W2017577437 countsByYear W20175774372019 @default.
• W2017577437 countsByYear W20175774372020 @default.
• W2017577437 crossrefType "journal-article" @default.
• W2017577437 hasAuthorship W2017577437A5015452702 @default.
• W2017577437 hasAuthorship W2017577437A5033029228 @default.
• W2017577437 hasAuthorship W2017577437A5049075689 @default.
• W2017577437 hasAuthorship W2017577437A5062904109 @default.
• W2017577437 hasAuthorship W2017577437A5067570459 @default.
• W2017577437 hasAuthorship W2017577437A5077919557 @default.
• W2017577437 hasAuthorship W2017577437A5084022811 @default.
• W2017577437 hasConcept C104317684 @default.
• W2017577437 hasConcept C116834253 @default.
• W2017577437 hasConcept C121332964 @default.
• W2017577437 hasConcept C135763542 @default.
• W2017577437 hasConcept C170734499 @default.
• W2017577437 hasConcept C2522767166 @default.
• W2017577437 hasConcept C31467283 @default.
• W2017577437 hasConcept C32220436 @default.
• W2017577437 hasConcept C41008148 @default.
• W2017577437 hasConcept C54355233 @default.
• W2017577437 hasConcept C59822182 @default.
• W2017577437 hasConcept C60644358 @default.

• next