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• W2017578093 abstract "A decrease in heart function with ageing might be related to an impairment of mitochondrial function, since these organelles produce the greatest fraction of ATP in the myocyte. Mitochondria extracted from Wistar rat hearts at 3, 14, 18 and 24 months of age were employed to evaluate the changes of the respiratory activity during lifetime. A slight decrease of the respiratory rate (QO2) was observed in the 14 month group with respect to the 3 month group when succinate was used as substrate, whereas the respiratory control index (RCI) in the presence of glutamate or succinate increased in the 24 month group. The latter result may be related to a condition of moderate hypertrophy that generally occurs in the ageing heart. Submitochondrial particles (SMP) were also prepared to study the superoxide radicals (O⨪2) production at the level of rotenone or antimycin-inhibited regions of the respiratory chain. A strong elevation in the O⨪2 generation was observed in the antimycin-inhibited region at 14 months of age; on the contrary, the rate of O⨪2 production remained unchanged in the 24 month group in comparison to the youngest group. These observations correlate well with the enhanced tissue level of oxidized glutathione that was observed at 14 and 18 months of age. The products of lipid peroxidation (TBARS) did not change in the rat heart at any of the ages measured, whereas the levels of fluorescent substances progressively increased beginning from 18 months of age, with a greater extent in the mitochondrial compartment. The present study suggests that age does not substantially affect mitochondrial respiration and energy output in the rat heart, while a greater production by cardiac mitochondria of superoxide anions in the adult rats (14 months) might accelerate the fluorescent pigment formation." @default.
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• W2017578093 date "1990-02-01" @default.
• W2017578093 modified "2023-09-23" @default.
• W2017578093 title "Mitochondrial function and superoxide generation from submitochondrial particles of aged rat hearts" @default.
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• W2017578093 doi "https://doi.org/10.1016/0005-2728(90)90021-u" @default.
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