FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017580680> ?p ?o ?g. }

• W2017580680 endingPage "2540" @default.
• W2017580680 startingPage "2530" @default.
• W2017580680 abstract "Abstract The patient (germline) genome can influence the pharmacokinetics and pharmacodynamics of cancer therapy. The field of pharmacogenetics (PGx) has primarily focused on genetic predictors of pharmacokinetics, largely ignoring pharmacodynamics, using a candidate approach to assess single-nucleotide polymorphisms (SNP) with known relevance to drug pharmacokinetics such as enzymes and transporters. A more comprehensive approach, the genome-wide association study, circumvents candidate selection but suffers because of the necessity for substantial statistical correction. Pharmacogene panels, which interrogate hundreds to thousands of SNPs in genes with known relevance to drug pharmacokinetics or pharmacodynamics, represent an attractive compromise between these approaches. Panels with defined or customizable SNP lists have been used to discover SNPs that predict pharmacokinetics or pharmacodynamics of cancer drugs, most of which await successful replication. PGx discovery, particularly for SNPs that influence drug pharmacodynamics, is limited by weaknesses in both genetic and phenotypic data. Selection of candidate SNPs for inclusion on pharmacogene panels is difficult because of limited understanding of biology and pharmacology. Phenotypes used in analyses have primarily been complex toxicities that are known to be multifactorial. A more measured approach, in which sensitive phenotypes are used in place of complex clinical outcomes, will improve the success rate of pharmacodynamics SNP discovery and ultimately enable identification of pharmacodynamics SNPs with meaningful effects on treatment outcomes. See all articles in this CCR Focus section, “Progress in Pharmacodynamic Endpoints.” Clin Cancer Res; 20(10); 2530–40. ©2014 AACR." @default.
• W2017580680 created "2016-06-24" @default.
• W2017580680 creator A5011034688 @default.
• W2017580680 creator A5075359631 @default.
• W2017580680 date "2014-05-14" @default.
• W2017580680 modified "2023-10-03" @default.
• W2017580680 title "Using Pharmacogene Polymorphism Panels to Detect Germline Pharmacodynamic Markers in Oncology" @default.
• W2017580680 cites W1512691487 @default.
• W2017580680 cites W1964079064 @default.
• W2017580680 cites W1964966022 @default.
• W2017580680 cites W1967653499 @default.
• W2017580680 cites W1971983191 @default.
• W2017580680 cites W1976397744 @default.
• W2017580680 cites W1977486610 @default.
• W2017580680 cites W1993682664 @default.
• W2017580680 cites W1995808879 @default.
• W2017580680 cites W1997969132 @default.
• W2017580680 cites W2002318423 @default.
• W2017580680 cites W2003955744 @default.
• W2017580680 cites W2005317772 @default.
• W2017580680 cites W2013136572 @default.
• W2017580680 cites W2016234006 @default.
• W2017580680 cites W2019133808 @default.
• W2017580680 cites W2019545869 @default.
• W2017580680 cites W2020144275 @default.
• W2017580680 cites W2022969736 @default.
• W2017580680 cites W2024913341 @default.
• W2017580680 cites W2025955865 @default.
• W2017580680 cites W2028139400 @default.
• W2017580680 cites W2030243235 @default.
• W2017580680 cites W2031158773 @default.
• W2017580680 cites W2035070850 @default.
• W2017580680 cites W2041323112 @default.
• W2017580680 cites W2042416548 @default.
• W2017580680 cites W2051643304 @default.
• W2017580680 cites W2052140659 @default.
• W2017580680 cites W2055827464 @default.
• W2017580680 cites W2062675856 @default.
• W2017580680 cites W2074024827 @default.
• W2017580680 cites W2077234437 @default.
• W2017580680 cites W2078462908 @default.
• W2017580680 cites W2080800321 @default.
• W2017580680 cites W2081762164 @default.
• W2017580680 cites W2082048952 @default.
• W2017580680 cites W2086577799 @default.
• W2017580680 cites W2088428206 @default.
• W2017580680 cites W2090623862 @default.
• W2017580680 cites W2091554302 @default.
• W2017580680 cites W2095993519 @default.
• W2017580680 cites W2100917151 @default.
• W2017580680 cites W2119366535 @default.
• W2017580680 cites W2120187456 @default.
• W2017580680 cites W2124776241 @default.
• W2017580680 cites W2125399228 @default.
• W2017580680 cites W2131043327 @default.
• W2017580680 cites W2136797685 @default.
• W2017580680 cites W2137475682 @default.
• W2017580680 cites W2142168567 @default.
• W2017580680 cites W2142970669 @default.
• W2017580680 cites W2149372853 @default.
• W2017580680 cites W2149952483 @default.
• W2017580680 cites W2152922562 @default.
• W2017580680 cites W2156602023 @default.
• W2017580680 cites W2160165070 @default.
• W2017580680 cites W2161400558 @default.
• W2017580680 cites W2316521727 @default.
• W2017580680 cites W2398077306 @default.
• W2017580680 cites W3093265161 @default.
• W2017580680 doi "https://doi.org/10.1158/1078-0432.ccr-13-2780" @default.
• W2017580680 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24831276" @default.
• W2017580680 hasPublicationYear "2014" @default.
• W2017580680 type Work @default.
• W2017580680 sameAs 2017580680 @default.
• W2017580680 citedByCount "20" @default.
• W2017580680 countsByYear W20175806802014 @default.
• W2017580680 countsByYear W20175806802015 @default.
• W2017580680 countsByYear W20175806802016 @default.
• W2017580680 countsByYear W20175806802017 @default.
• W2017580680 countsByYear W20175806802018 @default.
• W2017580680 countsByYear W20175806802019 @default.
• W2017580680 countsByYear W20175806802020 @default.
• W2017580680 countsByYear W20175806802021 @default.
• W2017580680 countsByYear W20175806802022 @default.
• W2017580680 crossrefType "journal-article" @default.
• W2017580680 hasAuthorship W2017580680A5011034688 @default.
• W2017580680 hasAuthorship W2017580680A5075359631 @default.
• W2017580680 hasConcept C104317684 @default.
• W2017580680 hasConcept C106208931 @default.
• W2017580680 hasConcept C111113717 @default.
• W2017580680 hasConcept C112705442 @default.
• W2017580680 hasConcept C135763542 @default.
• W2017580680 hasConcept C139275648 @default.
• W2017580680 hasConcept C153209595 @default.
• W2017580680 hasConcept C170734499 @default.
• W2017580680 hasConcept C54355233 @default.
• W2017580680 hasConcept C55775858 @default.
• W2017580680 hasConcept C60644358 @default.
• W2017580680 hasConcept C70721500 @default.

• next