FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017581208> ?p ?o ?g. }

• W2017581208 endingPage "148" @default.
• W2017581208 startingPage "140" @default.
• W2017581208 abstract "The antagonism of cellular excitability in insects is mediated by a family of ionotropic receptors, the ligand-gated chloride channels. In insects these inhibitory receptors include synaptic GABA and histamine receptors, functionally analogous to vertebrate GABA and glycine receptors, and glutamate receptors that appear to be unique to invertebrates. The ligand-gated chloride channel family in insects includes two well-validated targets for insect control agents: GABA receptors, which are the targets for a structural variety of small-molecule insecticides (polychlorocycloalkanes such as dieldrin and phenylpyrazoles such as fipronil) that have been used widely in agriculture; and glutamate receptors, which are the targets of macrocyclic lactone natural products (the avermectins) that have yielded not only commercial insecticides but also anthelminthic agents (i.e., ivermectin) employed in animal and human health. The availability of the complete genome sequence of the insect model system Drosophila melanogaster has permitted the identification of all of the genes encoding proteins with structural similarity to known ligand-gated chloride channel subunits (ligand-gated chloride channel homologs or LCCHs). Here, we review the present status of knowledge of the structure and function of the proteins encoded by this compact gene family. The 12 LCCH genes of D. melanogaster exhibit a surprising degree of structural diversity, which is further enhanced for some subunits by a variety of post-transcriptional and post-translational modifications. Although the structures of the gene products encoded by this small gene family are now well characterized, surprisingly little is known of the biological functions of the majority of them and the structures of most native receptors remain unknown." @default.
• W2017581208 created "2016-06-24" @default.
• W2017581208 creator A5024920961 @default.
• W2017581208 creator A5050257302 @default.
• W2017581208 date "2010-06-01" @default.
• W2017581208 modified "2023-10-16" @default.
• W2017581208 title "The ligand-gated chloride channel gene family of Drosophila melanogaster" @default.
• W2017581208 cites W1505693447 @default.
• W2017581208 cites W1970354415 @default.
• W2017581208 cites W1971541505 @default.
• W2017581208 cites W1977433867 @default.
• W2017581208 cites W1980236138 @default.
• W2017581208 cites W1981049652 @default.
• W2017581208 cites W1984095012 @default.
• W2017581208 cites W1985317176 @default.
• W2017581208 cites W1986102335 @default.
• W2017581208 cites W1993827187 @default.
• W2017581208 cites W1993984710 @default.
• W2017581208 cites W1997437840 @default.
• W2017581208 cites W2008492335 @default.
• W2017581208 cites W2012829543 @default.
• W2017581208 cites W2015954852 @default.
• W2017581208 cites W2024103675 @default.
• W2017581208 cites W2025036638 @default.
• W2017581208 cites W2025376799 @default.
• W2017581208 cites W2029552208 @default.
• W2017581208 cites W2036378698 @default.
• W2017581208 cites W2036876463 @default.
• W2017581208 cites W2052600754 @default.
• W2017581208 cites W2053072415 @default.
• W2017581208 cites W2053283112 @default.
• W2017581208 cites W2057761743 @default.
• W2017581208 cites W2059786703 @default.
• W2017581208 cites W2060287150 @default.
• W2017581208 cites W2061680089 @default.
• W2017581208 cites W2071662051 @default.
• W2017581208 cites W2072738591 @default.
• W2017581208 cites W2077853328 @default.
• W2017581208 cites W2081160811 @default.
• W2017581208 cites W2081602909 @default.
• W2017581208 cites W2084708600 @default.
• W2017581208 cites W2086375313 @default.
• W2017581208 cites W2086655626 @default.
• W2017581208 cites W2088280297 @default.
• W2017581208 cites W2088638836 @default.
• W2017581208 cites W2088814430 @default.
• W2017581208 cites W2089696357 @default.
• W2017581208 cites W2094119815 @default.
• W2017581208 cites W2099352796 @default.
• W2017581208 cites W2109759870 @default.
• W2017581208 cites W2124102028 @default.
• W2017581208 cites W2130661030 @default.
• W2017581208 cites W2136185611 @default.
• W2017581208 cites W2141652419 @default.
• W2017581208 cites W2146025280 @default.
• W2017581208 cites W2158714788 @default.
• W2017581208 cites W2160489426 @default.
• W2017581208 doi "https://doi.org/10.1016/j.pestbp.2009.09.002" @default.
• W2017581208 hasPublicationYear "2010" @default.
• W2017581208 type Work @default.
• W2017581208 sameAs 2017581208 @default.
• W2017581208 citedByCount "39" @default.
• W2017581208 countsByYear W20175812082012 @default.
• W2017581208 countsByYear W20175812082014 @default.
• W2017581208 countsByYear W20175812082015 @default.
• W2017581208 countsByYear W20175812082016 @default.
• W2017581208 countsByYear W20175812082017 @default.
• W2017581208 countsByYear W20175812082018 @default.
• W2017581208 countsByYear W20175812082019 @default.
• W2017581208 countsByYear W20175812082020 @default.
• W2017581208 countsByYear W20175812082021 @default.
• W2017581208 countsByYear W20175812082022 @default.
• W2017581208 countsByYear W20175812082023 @default.
• W2017581208 crossrefType "journal-article" @default.
• W2017581208 hasAuthorship W2017581208A5024920961 @default.
• W2017581208 hasAuthorship W2017581208A5050257302 @default.
• W2017581208 hasConcept C104317684 @default.
• W2017581208 hasConcept C115955781 @default.
• W2017581208 hasConcept C141231307 @default.
• W2017581208 hasConcept C145822097 @default.
• W2017581208 hasConcept C170493617 @default.
• W2017581208 hasConcept C2780104201 @default.
• W2017581208 hasConcept C50254741 @default.
• W2017581208 hasConcept C54355233 @default.
• W2017581208 hasConcept C55493867 @default.
• W2017581208 hasConcept C5911399 @default.
• W2017581208 hasConcept C61174792 @default.
• W2017581208 hasConcept C82617044 @default.
• W2017581208 hasConcept C86803240 @default.
• W2017581208 hasConcept C95444343 @default.
• W2017581208 hasConceptScore W2017581208C104317684 @default.
• W2017581208 hasConceptScore W2017581208C115955781 @default.
• W2017581208 hasConceptScore W2017581208C141231307 @default.
• W2017581208 hasConceptScore W2017581208C145822097 @default.
• W2017581208 hasConceptScore W2017581208C170493617 @default.
• W2017581208 hasConceptScore W2017581208C2780104201 @default.
• W2017581208 hasConceptScore W2017581208C50254741 @default.
• W2017581208 hasConceptScore W2017581208C54355233 @default.

• next