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- W2017584538 abstract "It has recently been shown that testing for association in the presence of linkage using a score test based on a gamma random effects (GRE) model is substantially more powerful than using the Family-Based Association Test. A reason for the increased power lies in better specification of the within family correlation structure, induced by linkage. The GRE, as presented in (Jonasdottir et al. 2007 Genet Epidemiol. 31:528–540), only considers one marker at a time and does not readily handle missing parental information. Here we extend the GRE to incorporate information from more than one marker. This extension leads to a haplotype GRE test and also to efficient handling of missing data on parental genotypes. We show that the haplotype GRE, the H-GRE, is substantially more powerful than the haplotype FBAT, the Haplotype-Based-Association Test. We demonstrate the usefulness of the extended GRE, by reanalyzing the collaborative study on the genetics of alcoholism data, allowing for missing parental information. Genet. Epidemiol. 2008. © 2008 Wiley-Liss, Inc." @default.
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- W2017584538 date "2008-07-01" @default.
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- W2017584538 title "Testing association in the presence of linkage using the GRE and multiple markers" @default.
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- W2017584538 doi "https://doi.org/10.1002/gepi.20315" @default.
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