FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017589730> ?p ?o ?g. }

• W2017589730 endingPage "17076" @default.
• W2017589730 startingPage "17065" @default.
• W2017589730 abstract "The role and the mechanisms by which β1 integrins regulate the survival and chemoresistance of T cell acute lymphoblastic leukemia (T-ALL) still are poorly addressed. In this study, we demonstrate in T-ALL cell lines and primary blasts, that engagement of α2β1 integrin with its ligand collagen I (ColI), reduces doxorubicin-induced apoptosis, whereas fibronectin (Fn) had no effect. ColI but not Fn inhibited doxorubicin-induced mitochondrial depolarization, cytochrome c release, and activation of caspase-9 and -3. ColI but not Fn also prevented doxorubicin from down-regulating the levels of the prosurvival Bcl-2 protein family member Mcl-1. The effect of ColI on Mcl-1 occurred through the inhibition of doxorubicin-induced activation of c-Jun N-terminal kinase (JNK). Mcl-1 knockdown experiments showed that the maintenance of Mcl-1 levels is essential for ColI-mediated T-ALL cell survival. Furthermore, activation of MAPK/ERK, but not PI3K/AKT, is required for ColI-mediated inhibition of doxorubicin-induced JNK activation and apoptosis and for ColI-mediated maintenance of Mcl-1 levels. Thus, our study identifies α2β1 integrin as an important survival pathway in drug-induced apoptosis of T-ALL cells and suggests that its activation can contribute to the generation of drug resistance." @default.
• W2017589730 created "2016-06-24" @default.
• W2017589730 creator A5009615078 @default.
• W2017589730 creator A5017519158 @default.
• W2017589730 creator A5021478572 @default.
• W2017589730 creator A5024742843 @default.
• W2017589730 creator A5042030060 @default.
• W2017589730 creator A5058348689 @default.
• W2017589730 creator A5075229788 @default.
• W2017589730 creator A5085251031 @default.
• W2017589730 date "2012-05-01" @default.
• W2017589730 modified "2023-10-10" @default.
• W2017589730 title "α2β1 Integrin Promotes Chemoresistance against Doxorubicin in Cancer Cells through Extracellular Signal-regulated Kinase (ERK)" @default.
• W2017589730 cites W1483990506 @default.
• W2017589730 cites W1494507441 @default.
• W2017589730 cites W1528751727 @default.
• W2017589730 cites W1554419184 @default.
• W2017589730 cites W1965570423 @default.
• W2017589730 cites W1979639432 @default.
• W2017589730 cites W1981393628 @default.
• W2017589730 cites W1982254984 @default.
• W2017589730 cites W1982349843 @default.
• W2017589730 cites W1986439979 @default.
• W2017589730 cites W1988479585 @default.
• W2017589730 cites W1990376658 @default.
• W2017589730 cites W1994547999 @default.
• W2017589730 cites W2009183786 @default.
• W2017589730 cites W2011468496 @default.
• W2017589730 cites W2014702149 @default.
• W2017589730 cites W2018439544 @default.
• W2017589730 cites W2019136692 @default.
• W2017589730 cites W2022279230 @default.
• W2017589730 cites W2025839193 @default.
• W2017589730 cites W2035147260 @default.
• W2017589730 cites W2039011704 @default.
• W2017589730 cites W2047310850 @default.
• W2017589730 cites W2065159936 @default.
• W2017589730 cites W2067190714 @default.
• W2017589730 cites W2085639632 @default.
• W2017589730 cites W2086033457 @default.
• W2017589730 cites W2108144981 @default.
• W2017589730 cites W2116464129 @default.
• W2017589730 cites W2119543578 @default.
• W2017589730 cites W2120243513 @default.
• W2017589730 cites W21272024 @default.
• W2017589730 cites W2128573874 @default.
• W2017589730 cites W2134864772 @default.
• W2017589730 cites W2135491950 @default.
• W2017589730 cites W2136073669 @default.
• W2017589730 cites W2137965475 @default.
• W2017589730 cites W2142324818 @default.
• W2017589730 cites W2147000598 @default.
• W2017589730 cites W2151670058 @default.
• W2017589730 cites W2157007010 @default.
• W2017589730 cites W2161549952 @default.
• W2017589730 cites W2163964890 @default.
• W2017589730 cites W2168142681 @default.
• W2017589730 cites W2169571069 @default.
• W2017589730 cites W2170103350 @default.
• W2017589730 cites W2345677677 @default.
• W2017589730 doi "https://doi.org/10.1074/jbc.m112.349365" @default.
• W2017589730 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3366820" @default.
• W2017589730 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22457358" @default.
• W2017589730 hasPublicationYear "2012" @default.
• W2017589730 type Work @default.
• W2017589730 sameAs 2017589730 @default.
• W2017589730 citedByCount "82" @default.
• W2017589730 countsByYear W20175897302012 @default.
• W2017589730 countsByYear W20175897302013 @default.
• W2017589730 countsByYear W20175897302014 @default.
• W2017589730 countsByYear W20175897302015 @default.
• W2017589730 countsByYear W20175897302016 @default.
• W2017589730 countsByYear W20175897302017 @default.
• W2017589730 countsByYear W20175897302018 @default.
• W2017589730 countsByYear W20175897302019 @default.
• W2017589730 countsByYear W20175897302020 @default.
• W2017589730 countsByYear W20175897302021 @default.
• W2017589730 countsByYear W20175897302022 @default.
• W2017589730 countsByYear W20175897302023 @default.
• W2017589730 crossrefType "journal-article" @default.
• W2017589730 hasAuthorship W2017589730A5009615078 @default.
• W2017589730 hasAuthorship W2017589730A5017519158 @default.
• W2017589730 hasAuthorship W2017589730A5021478572 @default.
• W2017589730 hasAuthorship W2017589730A5024742843 @default.
• W2017589730 hasAuthorship W2017589730A5042030060 @default.
• W2017589730 hasAuthorship W2017589730A5058348689 @default.
• W2017589730 hasAuthorship W2017589730A5075229788 @default.
• W2017589730 hasAuthorship W2017589730A5085251031 @default.
• W2017589730 hasBestOaLocation W20175897301 @default.
• W2017589730 hasConcept C1491633281 @default.
• W2017589730 hasConcept C184235292 @default.
• W2017589730 hasConcept C185592680 @default.
• W2017589730 hasConcept C190283241 @default.
• W2017589730 hasConcept C195687474 @default.
• W2017589730 hasConcept C2776694085 @default.
• W2017589730 hasConcept C2781303535 @default.
• W2017589730 hasConcept C502942594 @default.
• W2017589730 hasConcept C54355233 @default.

• next