FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017600547> ?p ?o ?g. }

• W2017600547 endingPage "311" @default.
• W2017600547 startingPage "305" @default.
• W2017600547 abstract "In vitro studies suggest that [3H]yohimbine binds to alpha 2-adrenoceptors while [3H]idazoxan binds preferentially at a non-adrenergic site. In order to compare in vitro with in vivo effects male New Zealand White rabbits received the following treatments: 5 days idazoxan 1.1 mg/kg per h, 10 days noradrenaline 46 micrograms/kg per h (intravenous infusion), 21 days amitriptyline 30 mg/kg per day (intraperitoneally) or vehicle. The effect of these treatments on the number of [3H]yohimbine and [3H]idazoxan binding sites was examined. Ten days noradrenaline infusion and 21 days amitripytyline treatment significantly reduced [3H]yohimbine binding in kidney and hindbrain membranes respectively, but had no significant effect on [3H]idazoxan binding. Five days idazoxan infusion significantly increased [3H]yohimbine binding in the forebrain, while a significant reduction in [3H]idazoxan binding sites in the kidney was observed. Thus differential regulation of the two binding sites was observed in vivo. These alterations in binding site number are consistent with the differing affinities of noradrenaline and idazoxan for the [3H]yohimbine and [3H]idazoxan binding sites previously observed in vitro and support the hypothesis that in the rabbit idazoxan binds preferentially at non-adrenergic sites while yohimbine binds to an alpha 2-adrenergic site. The idazoxan site may be an imidazoline type of receptor but further work, including functional studies, is required to substantiate this." @default.
• W2017600547 created "2016-06-24" @default.
• W2017600547 creator A5030074177 @default.
• W2017600547 creator A5038109299 @default.
• W2017600547 creator A5055557931 @default.
• W2017600547 creator A5074800822 @default.
• W2017600547 date "1990-02-01" @default.
• W2017600547 modified "2023-09-25" @default.
• W2017600547 title "Differences in the regulation of [3H]idazoxan and [3H]yohimbine binding sites in the rabbit" @default.
• W2017600547 cites W1936808599 @default.
• W2017600547 cites W1966440568 @default.
• W2017600547 cites W1969312557 @default.
• W2017600547 cites W1974106083 @default.
• W2017600547 cites W1979241608 @default.
• W2017600547 cites W2003011863 @default.
• W2017600547 cites W2005678334 @default.
• W2017600547 cites W2006875910 @default.
• W2017600547 cites W2007969402 @default.
• W2017600547 cites W2009623525 @default.
• W2017600547 cites W2012335673 @default.
• W2017600547 cites W2012994401 @default.
• W2017600547 cites W2013947594 @default.
• W2017600547 cites W2014321807 @default.
• W2017600547 cites W2014740637 @default.
• W2017600547 cites W2018894309 @default.
• W2017600547 cites W2021220758 @default.
• W2017600547 cites W2022595896 @default.
• W2017600547 cites W2026499926 @default.
• W2017600547 cites W2033723166 @default.
• W2017600547 cites W2034229123 @default.
• W2017600547 cites W2044938337 @default.
• W2017600547 cites W2072431227 @default.
• W2017600547 cites W2079208046 @default.
• W2017600547 cites W2086079369 @default.
• W2017600547 cites W2093744068 @default.
• W2017600547 cites W2174016629 @default.
• W2017600547 cites W2229032023 @default.
• W2017600547 cites W2244959895 @default.
• W2017600547 cites W2265391928 @default.
• W2017600547 cites W2885423306 @default.
• W2017600547 doi "https://doi.org/10.1016/0014-2999(90)90024-z" @default.
• W2017600547 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1970303" @default.
• W2017600547 hasPublicationYear "1990" @default.
• W2017600547 type Work @default.
• W2017600547 sameAs 2017600547 @default.
• W2017600547 citedByCount "16" @default.
• W2017600547 crossrefType "journal-article" @default.
• W2017600547 hasAuthorship W2017600547A5030074177 @default.
• W2017600547 hasAuthorship W2017600547A5038109299 @default.
• W2017600547 hasAuthorship W2017600547A5055557931 @default.
• W2017600547 hasAuthorship W2017600547A5074800822 @default.
• W2017600547 hasConcept C107824862 @default.
• W2017600547 hasConcept C123605464 @default.
• W2017600547 hasConcept C126322002 @default.
• W2017600547 hasConcept C134018914 @default.
• W2017600547 hasConcept C150903083 @default.
• W2017600547 hasConcept C158453852 @default.
• W2017600547 hasConcept C170493617 @default.
• W2017600547 hasConcept C185592680 @default.
• W2017600547 hasConcept C207001950 @default.
• W2017600547 hasConcept C2776885963 @default.
• W2017600547 hasConcept C2777676773 @default.
• W2017600547 hasConcept C2780648677 @default.
• W2017600547 hasConcept C2780939551 @default.
• W2017600547 hasConcept C40465926 @default.
• W2017600547 hasConcept C55493867 @default.
• W2017600547 hasConcept C71924100 @default.
• W2017600547 hasConcept C86803240 @default.
• W2017600547 hasConceptScore W2017600547C107824862 @default.
• W2017600547 hasConceptScore W2017600547C123605464 @default.
• W2017600547 hasConceptScore W2017600547C126322002 @default.
• W2017600547 hasConceptScore W2017600547C134018914 @default.
• W2017600547 hasConceptScore W2017600547C150903083 @default.
• W2017600547 hasConceptScore W2017600547C158453852 @default.
• W2017600547 hasConceptScore W2017600547C170493617 @default.
• W2017600547 hasConceptScore W2017600547C185592680 @default.
• W2017600547 hasConceptScore W2017600547C207001950 @default.
• W2017600547 hasConceptScore W2017600547C2776885963 @default.
• W2017600547 hasConceptScore W2017600547C2777676773 @default.
• W2017600547 hasConceptScore W2017600547C2780648677 @default.
• W2017600547 hasConceptScore W2017600547C2780939551 @default.
• W2017600547 hasConceptScore W2017600547C40465926 @default.
• W2017600547 hasConceptScore W2017600547C55493867 @default.
• W2017600547 hasConceptScore W2017600547C71924100 @default.
• W2017600547 hasConceptScore W2017600547C86803240 @default.
• W2017600547 hasIssue "3" @default.
• W2017600547 hasLocation W20176005471 @default.
• W2017600547 hasLocation W20176005472 @default.
• W2017600547 hasOpenAccess W2017600547 @default.
• W2017600547 hasPrimaryLocation W20176005471 @default.
• W2017600547 hasRelatedWork W1964810360 @default.
• W2017600547 hasRelatedWork W1975258718 @default.
• W2017600547 hasRelatedWork W1983573607 @default.
• W2017600547 hasRelatedWork W2017600547 @default.
• W2017600547 hasRelatedWork W2052453588 @default.
• W2017600547 hasRelatedWork W2070396511 @default.
• W2017600547 hasRelatedWork W2080160262 @default.
• W2017600547 hasRelatedWork W2086149148 @default.

• next