FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017601632> ?p ?o ?g. }

• W2017601632 endingPage "30" @default.
• W2017601632 startingPage "23" @default.
• W2017601632 abstract "In a double-blind randomized study, the suppression of ovarian activity and anti-conceptive effects on the cervix and endometrium were assessed during administration of two low-dose monophasic oral contraceptives (20 micrograms ethinyl estradiol [EE], 500 micrograms norethisterone--Eve 20 [Grünenthal, Aachen, Germany]; 20 micrograms EE, 150 micrograms desogestrel --Lovelle [Organon, Munich, Germany]). One hundred eighteen healthy women (ages: 18-35 years) were studied in 10 investigation centers during medication with either Eve 20 (n = 59) or Lovelle (n = 59). During three treatment cycles, ovarian activity was evaluated by sonographic determination of follicle-like structures (FLS) and by simultaneous assessment of serum endocrine profiles (gonadotropins LH and FSH, ovarian steroids estradiol [E2] and progesterone [P]). While on either treatment, no ovarian activity (as judged by no FLS and/or reduced sex steroid levels) was found in 90.8% (Eve 20) and 97.2% (Lovelle) of all investigated cycles. Follicular activity or cyst formation were detected in 18 of 173 cycles (Eve 20) and in 5 of 175 cycles (Lovelle), respectively. Gonadotropin levels were suppressed (LH < 6 IU/L, FSH < 8 IU/L) in most treatment cycles (Eve 20 76.6% vs. Lovelle: 84.8%). Serum E2 concentrations exceeding 0.1 nmol/L indicated residual follicular activity in 19.3% (Eve 20) versus 12.2% (Lovelle) of all cycles. An estimated by serum P levels over 5 nmol/L, ovulation had presumably occurred in 4.1% (Eve 20) versus 2.9% (Lovelle) of treatment cycles. However, when the sonographical and endocrinological data were combined, no ovulation was documented in any pill cycle. The quality and quantity of the cervical mucus was found to be minimal in the majority of women. Moreover, the endometrial layer was determined to be low by ultrasound during most pill cycles, indicating equally strong suppressive effects on endometrial receptivity by the two contraceptives. These observations suggest that ovarian activity is suppressed in the majority of cycles during use of low-dose contraceptives. This effect may mainly be medicated by pronounced suppression of serum gonadotropin levels. Strong anti-conceptive effects of these formulations on both cervical permeability and endometrial receptivity are additional factors ensuring the contraceptive efficacy of these formulations.The impact of two low-dose monophasic oral contraceptives (OCs) on suppression of ovarian activity, cervical permeability, and endometrial receptivity was investigated in a randomized double-blind study involving 118 healthy women 18-35 years of age recruited from 10 study centers in Germany. 59 women received Eve (20 mcg of ethinyl estradiol and 500 mcg of norethisterone) and 59 were given Lovelle (20 mcg of ethinyl estradiol and 150 mcg of desogestrel) for a total of 3 cycles. No ovarian activity, as assessed by sonographic determinations of follicle-like structures and serum endocrine profiles, was detected in 90.8% of cycles of Eve users and 97.2% of cycles in the Lovelle group. Follicular activity or cyst formation was found in 18 of 173 cycles of Eve users and 5 of 175 cycles of Lovelle users. Gonadotropin levels were suppressed (luteinizing hormone under 6 IU/L and follicle-stimulating hormone less than 8 IU/L) in 76.6% of treatment cycles in the Eve group and 84.8% of cycles in the Lovelle group. Serum estradiol concentrations exceeding 0.1 nmol/L, indicative of follicular activity, were recorded in 19.3% of cycles of Eve users and 12.2% of cycles in the Lovelle group. Although serum progesterone levels were over 5 nmol/L in 4.1% of cycles in the Eve group and 2.9% of those in the Lovelle group, consolidation of sonographic and endocrinologic data failed to document ovulation in any treatment cycles. The quantity and quality of cervical mucus was minimal in most women in both groups. Finally, the endometrial layer was determined to be low by ultrasonography during most pill cycles, confirming the OCs' equally strong suppressive effects on endometrial receptivity." @default.
• W2017601632 created "2016-06-24" @default.
• W2017601632 creator A5005259809 @default.
• W2017601632 creator A5027821685 @default.
• W2017601632 creator A5029001513 @default.
• W2017601632 date "1997-07-01" @default.
• W2017601632 modified "2023-10-03" @default.
• W2017601632 title "A comparative randomized trial on the impact of two low-dose oral contraceptives on ovarian activity, cervical permeability, and endometrial receptivity" @default.
• W2017601632 cites W1973138908 @default.
• W2017601632 cites W1979339177 @default.
• W2017601632 cites W1988511011 @default.
• W2017601632 cites W1989115647 @default.
• W2017601632 cites W1992433520 @default.
• W2017601632 cites W1999239203 @default.
• W2017601632 cites W2006497998 @default.
• W2017601632 cites W2009403426 @default.
• W2017601632 cites W2024181804 @default.
• W2017601632 cites W2024322692 @default.
• W2017601632 cites W2045415047 @default.
• W2017601632 cites W2064094264 @default.
• W2017601632 cites W2065895999 @default.
• W2017601632 cites W2078267684 @default.
• W2017601632 cites W2117202482 @default.
• W2017601632 cites W2171408802 @default.
• W2017601632 cites W2201444619 @default.
• W2017601632 cites W222479440 @default.
• W2017601632 cites W2287931800 @default.
• W2017601632 cites W2293181083 @default.
• W2017601632 cites W2569075054 @default.
• W2017601632 doi "https://doi.org/10.1016/s0010-7824(97)00070-x" @default.
• W2017601632 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9306028" @default.
• W2017601632 hasPublicationYear "1997" @default.
• W2017601632 type Work @default.
• W2017601632 sameAs 2017601632 @default.
• W2017601632 citedByCount "27" @default.
• W2017601632 countsByYear W20176016322012 @default.
• W2017601632 countsByYear W20176016322014 @default.
• W2017601632 countsByYear W20176016322015 @default.
• W2017601632 countsByYear W20176016322016 @default.
• W2017601632 countsByYear W20176016322017 @default.
• W2017601632 countsByYear W20176016322018 @default.
• W2017601632 countsByYear W20176016322020 @default.
• W2017601632 countsByYear W20176016322022 @default.
• W2017601632 crossrefType "journal-article" @default.
• W2017601632 hasAuthorship W2017601632A5005259809 @default.
• W2017601632 hasAuthorship W2017601632A5027821685 @default.
• W2017601632 hasAuthorship W2017601632A5029001513 @default.
• W2017601632 hasConcept C121608353 @default.
• W2017601632 hasConcept C126322002 @default.
• W2017601632 hasConcept C134018914 @default.
• W2017601632 hasConcept C143228043 @default.
• W2017601632 hasConcept C187785154 @default.
• W2017601632 hasConcept C2777702977 @default.
• W2017601632 hasConcept C2777740455 @default.
• W2017601632 hasConcept C2777956591 @default.
• W2017601632 hasConcept C2778324911 @default.
• W2017601632 hasConcept C2778575703 @default.
• W2017601632 hasConcept C2778782382 @default.
• W2017601632 hasConcept C2779058012 @default.
• W2017601632 hasConcept C2779076696 @default.
• W2017601632 hasConcept C2779279165 @default.
• W2017601632 hasConcept C2779441745 @default.
• W2017601632 hasConcept C2780186607 @default.
• W2017601632 hasConcept C2781039349 @default.
• W2017601632 hasConcept C2908647359 @default.
• W2017601632 hasConcept C2986817661 @default.
• W2017601632 hasConcept C71315377 @default.
• W2017601632 hasConcept C71924100 @default.
• W2017601632 hasConcept C99454951 @default.
• W2017601632 hasConceptScore W2017601632C121608353 @default.
• W2017601632 hasConceptScore W2017601632C126322002 @default.
• W2017601632 hasConceptScore W2017601632C134018914 @default.
• W2017601632 hasConceptScore W2017601632C143228043 @default.
• W2017601632 hasConceptScore W2017601632C187785154 @default.
• W2017601632 hasConceptScore W2017601632C2777702977 @default.
• W2017601632 hasConceptScore W2017601632C2777740455 @default.
• W2017601632 hasConceptScore W2017601632C2777956591 @default.
• W2017601632 hasConceptScore W2017601632C2778324911 @default.
• W2017601632 hasConceptScore W2017601632C2778575703 @default.
• W2017601632 hasConceptScore W2017601632C2778782382 @default.
• W2017601632 hasConceptScore W2017601632C2779058012 @default.
• W2017601632 hasConceptScore W2017601632C2779076696 @default.
• W2017601632 hasConceptScore W2017601632C2779279165 @default.
• W2017601632 hasConceptScore W2017601632C2779441745 @default.
• W2017601632 hasConceptScore W2017601632C2780186607 @default.
• W2017601632 hasConceptScore W2017601632C2781039349 @default.
• W2017601632 hasConceptScore W2017601632C2908647359 @default.
• W2017601632 hasConceptScore W2017601632C2986817661 @default.
• W2017601632 hasConceptScore W2017601632C71315377 @default.
• W2017601632 hasConceptScore W2017601632C71924100 @default.
• W2017601632 hasConceptScore W2017601632C99454951 @default.
• W2017601632 hasIssue "1" @default.
• W2017601632 hasLocation W20176016321 @default.
• W2017601632 hasLocation W20176016322 @default.
• W2017601632 hasOpenAccess W2017601632 @default.
• W2017601632 hasPrimaryLocation W20176016321 @default.
• W2017601632 hasRelatedWork W2043899786 @default.
• W2017601632 hasRelatedWork W2062834969 @default.

• next