FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017602012> ?p ?o ?g. }

• W2017602012 endingPage "5838" @default.
• W2017602012 startingPage "5831" @default.
• W2017602012 abstract "As a means to explore the influence of the nucleic acid backbone on the intercalative binding of ligands to DNA and RNA, we have determined the solution structure of a proflavine-bound 2′,5′-linked octamer duplex with the sequence GCCGCGGC. This structure represents the first NMR structure of an intercalated RNA duplex, of either backbone structural isomer. By comparison with X-ray crystal structures, we have identified similarities and differences between intercalated 3′,5′ and 2′,5′-linked RNA duplexes. First, the two forms of RNA have different sugar pucker geometries at the intercalated nucleotide steps, yet have the same interphosphate distances. Second, as in intercalated 3′,5′ RNA, the phosphate backbone angle ζ at the 2′,5′ RNA intercalation site prefers to be in the trans conformation, whereas unintercalated 2′,5′ and 3′,5′ RNA prefer the -gauche conformation. These observations provide new insights regarding the transitions required for intercalation of a phosphodiester-ribose backbone and suggest a possible contribution of the backbone to the origin of the nearest-neighbor exclusion principle. Thermodynamic studies presented for intercalation of both structural RNA isomers also reveal a surprising sensitivity of intercalator binding enthalpy and entropy to the details of RNA backbone structure." @default.
• W2017602012 created "2016-06-24" @default.
• W2017602012 creator A5007544119 @default.
• W2017602012 creator A5032617559 @default.
• W2017602012 creator A5060359400 @default.
• W2017602012 creator A5060856297 @default.
• W2017602012 creator A5069902435 @default.
• W2017602012 date "2009-03-23" @default.
• W2017602012 modified "2023-10-16" @default.
• W2017602012 title "Solution Structure and Thermodynamics of 2′,5′ RNA Intercalation" @default.
• W2017602012 cites W1030900860 @default.
• W2017602012 cites W131926939 @default.
• W2017602012 cites W1499559560 @default.
• W2017602012 cites W1515099738 @default.
• W2017602012 cites W1778619900 @default.
• W2017602012 cites W1895359142 @default.
• W2017602012 cites W1964171975 @default.
• W2017602012 cites W1966347805 @default.
• W2017602012 cites W1972459558 @default.
• W2017602012 cites W1974427934 @default.
• W2017602012 cites W1978099158 @default.
• W2017602012 cites W1981332920 @default.
• W2017602012 cites W1982743789 @default.
• W2017602012 cites W1997279199 @default.
• W2017602012 cites W2004469739 @default.
• W2017602012 cites W2004884179 @default.
• W2017602012 cites W2008753573 @default.
• W2017602012 cites W2017190541 @default.
• W2017602012 cites W2018999693 @default.
• W2017602012 cites W2028714513 @default.
• W2017602012 cites W2029667189 @default.
• W2017602012 cites W2034295729 @default.
• W2017602012 cites W2037937687 @default.
• W2017602012 cites W2041834854 @default.
• W2017602012 cites W2046862446 @default.
• W2017602012 cites W2050904973 @default.
• W2017602012 cites W2051023307 @default.
• W2017602012 cites W2051429815 @default.
• W2017602012 cites W2054603278 @default.
• W2017602012 cites W2054888779 @default.
• W2017602012 cites W2058915021 @default.
• W2017602012 cites W2059090023 @default.
• W2017602012 cites W2065719839 @default.
• W2017602012 cites W2067004650 @default.
• W2017602012 cites W2067878166 @default.
• W2017602012 cites W2073597465 @default.
• W2017602012 cites W2074959598 @default.
• W2017602012 cites W2075421893 @default.
• W2017602012 cites W2076006674 @default.
• W2017602012 cites W2081084498 @default.
• W2017602012 cites W2083805549 @default.
• W2017602012 cites W2087365335 @default.
• W2017602012 cites W2088666636 @default.
• W2017602012 cites W2091099187 @default.
• W2017602012 cites W2091502996 @default.
• W2017602012 cites W2093381148 @default.
• W2017602012 cites W2093687460 @default.
• W2017602012 cites W2095602166 @default.
• W2017602012 cites W2101668373 @default.
• W2017602012 cites W2116079511 @default.
• W2017602012 cites W2126104919 @default.
• W2017602012 cites W2132789779 @default.
• W2017602012 cites W2134994374 @default.
• W2017602012 cites W2136729627 @default.
• W2017602012 cites W2137415981 @default.
• W2017602012 cites W2147993766 @default.
• W2017602012 cites W2149936766 @default.
• W2017602012 cites W2157281440 @default.
• W2017602012 cites W2158638729 @default.
• W2017602012 cites W2158939298 @default.
• W2017602012 cites W2215098882 @default.
• W2017602012 cites W224669792 @default.
• W2017602012 cites W2318565229 @default.
• W2017602012 cites W2506200838 @default.
• W2017602012 cites W2897307963 @default.
• W2017602012 cites W2949250147 @default.
• W2017602012 cites W2952016738 @default.
• W2017602012 doi "https://doi.org/10.1021/ja810068e" @default.
• W2017602012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19309071" @default.
• W2017602012 hasPublicationYear "2009" @default.
• W2017602012 type Work @default.
• W2017602012 sameAs 2017602012 @default.
• W2017602012 citedByCount "18" @default.
• W2017602012 countsByYear W20176020122014 @default.
• W2017602012 countsByYear W20176020122016 @default.
• W2017602012 countsByYear W20176020122017 @default.
• W2017602012 countsByYear W20176020122018 @default.
• W2017602012 countsByYear W20176020122020 @default.
• W2017602012 countsByYear W20176020122021 @default.
• W2017602012 crossrefType "journal-article" @default.
• W2017602012 hasAuthorship W2017602012A5007544119 @default.
• W2017602012 hasAuthorship W2017602012A5032617559 @default.
• W2017602012 hasAuthorship W2017602012A5060359400 @default.
• W2017602012 hasAuthorship W2017602012A5060856297 @default.
• W2017602012 hasAuthorship W2017602012A5069902435 @default.
• W2017602012 hasConcept C104317684 @default.
• W2017602012 hasConcept C115624301 @default.
• W2017602012 hasConcept C126142528 @default.

• next