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• W2017602023 abstract "Abstract Objective The aim of this study was to evaluate bone involvement in patients with Gaucher disease ( GD ) and to propose a novel semi‐quantitative magnetic resonance imaging ( MRI ) staging. Methods MRI of the lumbar spine, femur, and tibia was performed in 24 patients with GD and 24 healthy controls. We also measured circulating levels of C‐C motif ligand‐3 ( CCL ‐3) chemokine, C‐telopeptide of collagen type‐1 ( CTX ), and tartrate‐resistant acid phosphatase isoform type‐b ( TRACP ‐5b). Results We used the following staging based on MRI data: stage I: region of interest ( ROI ) 1/2 of normal values and bone infiltration up to 30%; stage II: ROI 1/3 of normal values and bone infiltration from 30 to 60%; stage III: ROI 1/4 of normal values and bone infiltration from 60% to 80%; and stage IV: detection of epiphyseal infiltration, osteonecrosis and deformity regardless of the ROI 's values. All but two patients had abnormal MRI findings: 9 (37.5%), 6 (25%), 3 (12.5%), and 4 (16.7%) had stages I–IV, respectively. Patients with GD had elevated chitotriosidase, serum TRACP ‐5b, and CCL ‐3 levels ( P < 0.001). Conclusions We propose an easily reproducible semi‐quantitative scoring system and confirm that patients with GD have abnormal MRI bone findings and enhanced osteoclast activity possibly due to elevated CCL ‐3." @default.
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• W2017602023 date "2015-03-23" @default.
• W2017602023 modified "2023-10-03" @default.
• W2017602023 title "Evaluation of bone involvement in patients with Gaucher disease: a semi-quantitative magnetic resonance imaging method (using ROI estimation of bone lesion) as an alternative method to semi-quantitative methods used so far" @default.
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• W2017602023 doi "https://doi.org/10.1111/ejh.12504" @default.
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