FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017602823> ?p ?o ?g. }

• W2017602823 endingPage "747" @default.
• W2017602823 startingPage "744" @default.
• W2017602823 abstract "Summary Higher homocysteine (Hcy) levels are associated with cardiovascular risk. The aim of the present study was to evaluate the effect of simvastatin treatment on circulating Hcy levels in obese women without hypertension, diabetes or dyslipidaemia; and to determine whether the 677C>T polymorphism located in methylenetetrahydrofolate reductase ( NAD (P)H) ( MTHFR ) gene modulates the effects of this treatment on Hcy and nitrite (as a biomarker of nitric oxide ( NO ) bioavailability). Twenty‐five obese women (body mass index ≥ 30 kg/m 2 ) who had received 20 mg/day simvastatin for 6 weeks were enrolled in the study. Venous blood samples were collected to measure plasma biomarkers and gene polymorphisms. Simvastatin treatment significantly reduced total cholesterol, low‐density lipoprotein–cholesterol, thiobarbituric acid‐reactive substances, high‐sensitivity C‐reactive protein and Hcy, whereas nitrite levels were increased. The reduction in Hcy levels in carriers of the T allele was −20.3% compared with –9.4% in patients with the CC genotype. Importantly, before treatment, nitrite levels were significantly higher in patients with the CC genotype compared with T allele carriers, whereas after treatment these levels were similar between groups. Our findings demonstrate that obese women without comorbidities and carrying the T variant of the 677C>T polymorphism of MTHFR exhibit benefits with simvastatin treatment, mainly in terms of increased NO levels." @default.
• W2017602823 created "2016-06-24" @default.
• W2017602823 creator A5002216895 @default.
• W2017602823 creator A5005059145 @default.
• W2017602823 creator A5008581420 @default.
• W2017602823 creator A5019266438 @default.
• W2017602823 creator A5034759953 @default.
• W2017602823 creator A5035663367 @default.
• W2017602823 creator A5079869767 @default.
• W2017602823 creator A5085785878 @default.
• W2017602823 creator A5091297439 @default.
• W2017602823 date "2014-10-01" @default.
• W2017602823 modified "2023-10-04" @default.
• W2017602823 title "Homocysteine and nitrite levels are modulated by<i>MTHFR</i>677C>T polymorphism in obese women treated with simvastatin" @default.
• W2017602823 cites W1977719969 @default.
• W2017602823 cites W2013534650 @default.
• W2017602823 cites W2022118911 @default.
• W2017602823 cites W2038789773 @default.
• W2017602823 cites W2055713391 @default.
• W2017602823 cites W2116404316 @default.
• W2017602823 cites W2124378690 @default.
• W2017602823 cites W2127585900 @default.
• W2017602823 cites W2135526852 @default.
• W2017602823 cites W2146280876 @default.
• W2017602823 cites W2149997127 @default.
• W2017602823 cites W2154350322 @default.
• W2017602823 cites W2165715420 @default.
• W2017602823 doi "https://doi.org/10.1111/1440-1681.12284" @default.
• W2017602823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25115547" @default.
• W2017602823 hasPublicationYear "2014" @default.
• W2017602823 type Work @default.
• W2017602823 sameAs 2017602823 @default.
• W2017602823 citedByCount "6" @default.
• W2017602823 countsByYear W20176028232018 @default.
• W2017602823 countsByYear W20176028232019 @default.
• W2017602823 countsByYear W20176028232021 @default.
• W2017602823 countsByYear W20176028232022 @default.
• W2017602823 crossrefType "journal-article" @default.
• W2017602823 hasAuthorship W2017602823A5002216895 @default.
• W2017602823 hasAuthorship W2017602823A5005059145 @default.
• W2017602823 hasAuthorship W2017602823A5008581420 @default.
• W2017602823 hasAuthorship W2017602823A5019266438 @default.
• W2017602823 hasAuthorship W2017602823A5034759953 @default.
• W2017602823 hasAuthorship W2017602823A5035663367 @default.
• W2017602823 hasAuthorship W2017602823A5079869767 @default.
• W2017602823 hasAuthorship W2017602823A5085785878 @default.
• W2017602823 hasAuthorship W2017602823A5091297439 @default.
• W2017602823 hasConcept C104317684 @default.
• W2017602823 hasConcept C126322002 @default.
• W2017602823 hasConcept C134018914 @default.
• W2017602823 hasConcept C135763542 @default.
• W2017602823 hasConcept C178790620 @default.
• W2017602823 hasConcept C185592680 @default.
• W2017602823 hasConcept C2776179834 @default.
• W2017602823 hasConcept C2776329913 @default.
• W2017602823 hasConcept C2776384668 @default.
• W2017602823 hasConcept C2777090595 @default.
• W2017602823 hasConcept C2778163477 @default.
• W2017602823 hasConcept C2778270857 @default.
• W2017602823 hasConcept C2780221984 @default.
• W2017602823 hasConcept C43563269 @default.
• W2017602823 hasConcept C55493867 @default.
• W2017602823 hasConcept C71924100 @default.
• W2017602823 hasConcept C76252995 @default.
• W2017602823 hasConceptScore W2017602823C104317684 @default.
• W2017602823 hasConceptScore W2017602823C126322002 @default.
• W2017602823 hasConceptScore W2017602823C134018914 @default.
• W2017602823 hasConceptScore W2017602823C135763542 @default.
• W2017602823 hasConceptScore W2017602823C178790620 @default.
• W2017602823 hasConceptScore W2017602823C185592680 @default.
• W2017602823 hasConceptScore W2017602823C2776179834 @default.
• W2017602823 hasConceptScore W2017602823C2776329913 @default.
• W2017602823 hasConceptScore W2017602823C2776384668 @default.
• W2017602823 hasConceptScore W2017602823C2777090595 @default.
• W2017602823 hasConceptScore W2017602823C2778163477 @default.
• W2017602823 hasConceptScore W2017602823C2778270857 @default.
• W2017602823 hasConceptScore W2017602823C2780221984 @default.
• W2017602823 hasConceptScore W2017602823C43563269 @default.
• W2017602823 hasConceptScore W2017602823C55493867 @default.
• W2017602823 hasConceptScore W2017602823C71924100 @default.
• W2017602823 hasConceptScore W2017602823C76252995 @default.
• W2017602823 hasIssue "10" @default.
• W2017602823 hasLocation W20176028231 @default.
• W2017602823 hasLocation W20176028232 @default.
• W2017602823 hasOpenAccess W2017602823 @default.
• W2017602823 hasPrimaryLocation W20176028231 @default.
• W2017602823 hasRelatedWork W1771218551 @default.
• W2017602823 hasRelatedWork W1964794938 @default.
• W2017602823 hasRelatedWork W1974808961 @default.
• W2017602823 hasRelatedWork W2018773860 @default.
• W2017602823 hasRelatedWork W2020778665 @default.
• W2017602823 hasRelatedWork W2095656588 @default.
• W2017602823 hasRelatedWork W2350427003 @default.
• W2017602823 hasRelatedWork W2361415486 @default.
• W2017602823 hasRelatedWork W2388077527 @default.
• W2017602823 hasRelatedWork W2391125215 @default.
• W2017602823 hasVolume "41" @default.
• W2017602823 isParatext "false" @default.

• next