FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017604806> ?p ?o ?g. }

• W2017604806 endingPage "394" @default.
• W2017604806 startingPage "375" @default.
• W2017604806 abstract "1 The effects of two dihydropyridines, PY 108–068 (PY) and nicardipine (N), and two other calcium antagonists, verapamil (V) and diltiazem (D), on regional blood flow were measured in open-chest cats, anaesthetized with chloralose-urethane. 2 Each substance was infused at 3 different dose rates, each for 10 min. The total doses given were 5 plus 10 plus 35 (total of 50) μg/kg for PY, 10 plus 20 plus 70 (total of 100) μg/kg for N and 100 plus 200 plus 700 (total of 1000) μg/kg for V and D. 3 All substances lowered blood pressure and increased total peripheral conductance. Heart rate was lowered only by V, D and PY. Cardiac output was markedly increased only by the diyhydroypridine derivatives; D had small and V almost no effects. 4 All substances increased coronary flow and redistributed it in favour of the subepicardial layer. All substances also increased blood flow to the brain. The effects of verapamil were comparatively small. 5 Skeletal muscle flow was increased strongly by the two dihydropyridine derivatives. D and V had negligible effects. 6 Blood flow to stomach and small intestine was only slightly increased. Flow to the kidneys increased slightly in diltiazem-treated animals but did not change with all other treatments. Flow to the liver, the adrenals, and the spleen remained unchanged or showed a tendency to decrease. 7 The organ conductances which reflect the active changes in vascular tone better than blood flow values, showed that there was a tendency towards vasodilatation even in most organs where blood flow tended to decrease. 8 Results obtained in an earlier series of experiments with nifedipine were very similar to those described here for N, except that nifedipine was about twice as potent. 9 Calcium antagonists were thus neither general peripheral vasodilators nor did they show a uniform pattern of preferential sites of action. The most important common features were increases in coronary and cerebral blood flow and the most important differences the divergent effects of the dihydropyridines on one side and V and D on the other side on skeletal muscle flow. The size of this vascular bed may help to explain why dihydropyridines appear to be particularly potent as peripheral vasodilators." @default.
• W2017604806 created "2016-06-24" @default.
• W2017604806 creator A5056470023 @default.
• W2017604806 date "1983-02-01" @default.
• W2017604806 modified "2023-10-17" @default.
• W2017604806 title "Calcium antagonist and the peripheral circulation: differences and similarities between PY 108–068, nicardipine, verapamil and diltiazem" @default.
• W2017604806 cites W1561174251 @default.
• W2017604806 cites W1986613486 @default.
• W2017604806 cites W1991772915 @default.
• W2017604806 cites W2007182079 @default.
• W2017604806 cites W2008717306 @default.
• W2017604806 cites W2021553590 @default.
• W2017604806 cites W2028907713 @default.
• W2017604806 cites W2031343827 @default.
• W2017604806 cites W2036417518 @default.
• W2017604806 cites W2041184529 @default.
• W2017604806 cites W2043623939 @default.
• W2017604806 cites W2049907486 @default.
• W2017604806 cites W2054445365 @default.
• W2017604806 cites W2072877321 @default.
• W2017604806 cites W2084680926 @default.
• W2017604806 cites W2089258817 @default.
• W2017604806 cites W2089945924 @default.
• W2017604806 cites W2102896366 @default.
• W2017604806 cites W2122689055 @default.
• W2017604806 cites W2132924014 @default.
• W2017604806 cites W2142653656 @default.
• W2017604806 cites W2154216905 @default.
• W2017604806 cites W2154512973 @default.
• W2017604806 cites W2200883212 @default.
• W2017604806 cites W2409229957 @default.
• W2017604806 cites W2410507808 @default.
• W2017604806 cites W2411860504 @default.
• W2017604806 cites W2413710421 @default.
• W2017604806 cites W2413983911 @default.
• W2017604806 cites W2417190567 @default.
• W2017604806 cites W2417551936 @default.
• W2017604806 cites W2418379826 @default.
• W2017604806 cites W2418628105 @default.
• W2017604806 cites W2425510151 @default.
• W2017604806 cites W2432526609 @default.
• W2017604806 cites W2461720530 @default.
• W2017604806 cites W2466096268 @default.
• W2017604806 cites W2467854765 @default.
• W2017604806 cites W83991394 @default.
• W2017604806 doi "https://doi.org/10.1111/j.1476-5381.1983.tb09403.x" @default.
• W2017604806 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2044696" @default.
• W2017604806 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6831117" @default.
• W2017604806 hasPublicationYear "1983" @default.
• W2017604806 type Work @default.
• W2017604806 sameAs 2017604806 @default.
• W2017604806 citedByCount "128" @default.
• W2017604806 countsByYear W20176048062013 @default.
• W2017604806 countsByYear W20176048062014 @default.
• W2017604806 countsByYear W20176048062020 @default.
• W2017604806 crossrefType "journal-article" @default.
• W2017604806 hasAuthorship W2017604806A5056470023 @default.
• W2017604806 hasBestOaLocation W20176048062 @default.
• W2017604806 hasConcept C120770815 @default.
• W2017604806 hasConcept C126322002 @default.
• W2017604806 hasConcept C134018914 @default.
• W2017604806 hasConcept C158846371 @default.
• W2017604806 hasConcept C185592680 @default.
• W2017604806 hasConcept C2776725644 @default.
• W2017604806 hasConcept C2776741139 @default.
• W2017604806 hasConcept C2777022698 @default.
• W2017604806 hasConcept C2777953023 @default.
• W2017604806 hasConcept C2778043224 @default.
• W2017604806 hasConcept C519063684 @default.
• W2017604806 hasConcept C71924100 @default.
• W2017604806 hasConcept C84393581 @default.
• W2017604806 hasConceptScore W2017604806C120770815 @default.
• W2017604806 hasConceptScore W2017604806C126322002 @default.
• W2017604806 hasConceptScore W2017604806C134018914 @default.
• W2017604806 hasConceptScore W2017604806C158846371 @default.
• W2017604806 hasConceptScore W2017604806C185592680 @default.
• W2017604806 hasConceptScore W2017604806C2776725644 @default.
• W2017604806 hasConceptScore W2017604806C2776741139 @default.
• W2017604806 hasConceptScore W2017604806C2777022698 @default.
• W2017604806 hasConceptScore W2017604806C2777953023 @default.
• W2017604806 hasConceptScore W2017604806C2778043224 @default.
• W2017604806 hasConceptScore W2017604806C519063684 @default.
• W2017604806 hasConceptScore W2017604806C71924100 @default.
• W2017604806 hasConceptScore W2017604806C84393581 @default.
• W2017604806 hasIssue "2" @default.
• W2017604806 hasLocation W20176048061 @default.
• W2017604806 hasLocation W20176048062 @default.
• W2017604806 hasLocation W20176048063 @default.
• W2017604806 hasLocation W20176048064 @default.
• W2017604806 hasOpenAccess W2017604806 @default.
• W2017604806 hasPrimaryLocation W20176048061 @default.
• W2017604806 hasRelatedWork W2003979082 @default.
• W2017604806 hasRelatedWork W2070970297 @default.
• W2017604806 hasRelatedWork W2167758093 @default.
• W2017604806 hasRelatedWork W2335578657 @default.
• W2017604806 hasRelatedWork W2350232202 @default.
• W2017604806 hasRelatedWork W2352138709 @default.
• W2017604806 hasRelatedWork W2411636280 @default.

• next