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• W2017605205 abstract "<h3>Background/aims:</h3> Impaired inhibition of the alternative complement pathway by complement factor H (CFH) is linked to age-related macular degeneration (AMD) based on the strong association between <i>CFH</i> variant and AMD. <i>Chlamydia pneumoniae</i> (<i>C pneumoniae</i>) infection can trigger the alternative pathway, but the evidence for an association between <i>C pneumoniae</i> and AMD is contradictory. This study investigated whether <i>C pneumoniae</i> infection is associated with AMD and whether the presence of <i>C pneumonia</i> modulates AMD risk conferred by <i>CFH</i> variants. <h3>Methods:</h3> Genomic DNA extracted from peripheral blood of 148 advanced AMD patients and 162 controls was subjected to Taqman and PCR-RFLP for the <i>CFH</i> polymorphism and PCR for the <i>C pneumoniae</i> gene. Genomic DNA was also examined from microdissected macular cells from 59 AMD and 16 age-matched non-AMD archived slides. χ² testing was performed for case-control analysis. <h3>Results:</h3> <i>C pneumoniae</i> infection was associated with increased risk of AMD (OR = 2.17, p<0.017). A <i>CFH</i> variant was also linked to increased risk of AMD (OR = 1.98, p<0.0001). However, no relationship was found between risk-conferring <i>CFH</i> variant and <i>C pneumoniae</i> (OR = 1.81, p = 0.08). <h3>Conclusion:</h3> There is a possible association between AMD and <i>C pneumoniae</i> infection, although CFH may not be directly involved in the pathogenesis of <i>C pneumoniae</i> infection-mediated AMD." @default.
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• W2017605205 date "2008-11-07" @default.
• W2017605205 modified "2023-10-16" @default.
• W2017605205 title "Chlamydia pneumoniae infection, complement factor H variants and age-related macular degeneration" @default.
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• W2017605205 doi "https://doi.org/10.1136/bjo.2008.145383" @default.
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