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- W2017606650 abstract "Directed accessibility mediated by antigen-receptor gene enhancers ensures developmental stage–specific activation of V(D)J recombination. Here, we used a combination of in vitro and in vivo assays to explore the mechanisms that regulate immunoglobulin μ heavy chain gene enhancer–dependent chromatin accessibility. Ets-1 or PU.1 bound to μ enhancer–containing plasmids assembled into chromatin in vitro and increased restriction enzyme access to a proximal site. In complementary analyses, expression of PU.1 in Ets-1-containing 2017 pro-T cells or NIH 3T3 cells induced sterile Iμ transcripts at the IgH locus and increased accessibility of the endogenous μ enhancer to restriction endonucleases. These observations suggest that one role of PU.1 is to increase accessibility of the μ locus to initiate heavy chain gene expression." @default.
- W2017606650 created "2016-06-24" @default.
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- W2017606650 date "1999-07-01" @default.
- W2017606650 modified "2023-10-11" @default.
- W2017606650 title "ETS Protein–Dependent Accessibility Changes at the Immunoglobulin μ Heavy Chain Enhancer" @default.
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- W2017606650 doi "https://doi.org/10.1016/s1074-7613(00)80077-1" @default.
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