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- W2017607178 abstract "Dengue fever (DF) is the most prevalent arthropod-borne viral disease which affects humans. DF is caused by the four dengue virus (DENV) serotypes, which are transmitted to the host by the mosquito Aedes aegypti that has key roles in DENV infection, replication, and viral transmission (vector competence). Mosquito saliva also plays an important role during DENV transmission. In this study, we detected the presence of sialic acid (Sia) in Aedes aegypti tissues, which may have an important role during DENV-vector competence. We also identified genome sequences encoding enzymes involved in Sia pathways. The cDNA for Aedes aegypti CMP-Sia synthase (CSAS) was amplified, cloned, and functionally evaluated via the complementation of LEC29.Lec32 CSAS-deficient CHO cells. Aedes CSAS-transfected LEC29.Lec32 cells were able to express Sia moieties on the cell surface. Sequences related to α -2,6-sialyltransferase were detected in the Aedes aegypti genome. Likewise, we identified Sia- α -2,6-DENV interactions in different mosquito tissues. In addition, we evaluated the possible role of sialylated molecules in a salivary gland extract during DENV internalization in mammalian cells. The knowledge of early DENV-host interactions could facilitate a better understanding of viral tropism and pathogenesis to allow the development of new strategies for controlling DENV transmission." @default.
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- W2017607178 date "2015-01-01" @default.
- W2017607178 modified "2023-10-17" @default.
- W2017607178 title "Sialic Acid Expression in the Mosquito<i>Aedes aegypti</i>and Its Possible Role in Dengue Virus-Vector Interactions" @default.
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- W2017607178 cites W1601252917 @default.
- W2017607178 cites W1777180563 @default.
- W2017607178 cites W1966396614 @default.
- W2017607178 cites W1966544875 @default.
- W2017607178 cites W1966674139 @default.
- W2017607178 cites W1976493080 @default.
- W2017607178 cites W1976830636 @default.
- W2017607178 cites W1982584351 @default.
- W2017607178 cites W1990748978 @default.
- W2017607178 cites W1990904999 @default.
- W2017607178 cites W1992364486 @default.
- W2017607178 cites W1993962142 @default.
- W2017607178 cites W1999716146 @default.
- W2017607178 cites W2000659638 @default.
- W2017607178 cites W2003474351 @default.
- W2017607178 cites W2010696972 @default.
- W2017607178 cites W2014434275 @default.
- W2017607178 cites W2018400133 @default.
- W2017607178 cites W2022512829 @default.
- W2017607178 cites W2024115143 @default.
- W2017607178 cites W2029824234 @default.
- W2017607178 cites W2032046378 @default.
- W2017607178 cites W2032575994 @default.
- W2017607178 cites W2032814880 @default.
- W2017607178 cites W2036493629 @default.
- W2017607178 cites W2044091406 @default.
- W2017607178 cites W2046466191 @default.
- W2017607178 cites W2053233371 @default.
- W2017607178 cites W2055923704 @default.
- W2017607178 cites W2059095830 @default.
- W2017607178 cites W2066268626 @default.
- W2017607178 cites W2069767991 @default.
- W2017607178 cites W2074120679 @default.
- W2017607178 cites W2074955153 @default.
- W2017607178 cites W2079853066 @default.
- W2017607178 cites W2083066821 @default.
- W2017607178 cites W2083448965 @default.
- W2017607178 cites W2083697049 @default.
- W2017607178 cites W2087274576 @default.
- W2017607178 cites W2091764376 @default.
- W2017607178 cites W2092919273 @default.
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- W2017607178 cites W2104643105 @default.
- W2017607178 cites W2109232796 @default.
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- W2017607178 cites W2130984786 @default.
- W2017607178 cites W2132527856 @default.
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- W2017607178 cites W2153224565 @default.
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- W2017607178 doi "https://doi.org/10.1155/2015/504187" @default.
- W2017607178 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4385653" @default.
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