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• W2017607478 abstract "The effects of some laxatives were examined on the formation of histamine, 5-hydroxytryptamine (5-HT) and prostaglandin-like material (PG-LM) by rat intestine in-vitro. Castor oil, senna, sulphosuccinate and bisacodyl, but not mannitol or lactulose, in doses that cause laxation, increased the formation of histamine, 5-HT and PG-LM. Indomethacin or hydrocortisone reduced the increase of PG-LM formation. The data support the idea that the laxative effects of these intestinal secretagogues are due to increased intestinal production of PG-LM, histamine and 5-HT." @default.
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• W2017607478 date "1986-08-01" @default.
• W2017607478 modified "2023-10-13" @default.
• W2017607478 title "Laxatives and the production of autacoids by rat colon" @default.
• W2017607478 doi "https://doi.org/10.1111/j.2042-7158.1986.tb03097.x" @default.
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