FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017607536> ?p ?o ?g. }

• W2017607536 endingPage "e2325" @default.
• W2017607536 startingPage "e2325" @default.
• W2017607536 abstract "Nitric oxide (NO), a key antimicrobial molecule, was previously shown to exert a dual role in paracoccidioidomycosis, an endemic fungal infection in Latin America. In the intravenous and peritoneal models of infection, NO production was associated with efficient fungal clearance but also with non-organized granulomatous lesions. Because paracoccidioidomycosis is a pulmonary infection, we aimed to characterize the role of NO in a pulmonary model of infection.C57Bl/6 wild type (WT) and iNOS(-/-) mice were i.t. infected with 1×10(6) Paracoccidioides brasiliensis yeasts and studied at several post-infection periods. Unexpectedly, at week 2 of infection, iNOS(-/-) mice showed decreased pulmonary fungal burdens associated with an M2-like macrophage profile, which expressed high levels of TGF-β impaired ability of ingesting fungal cells. This early decreased fungal loads were concomitant with increased DTH reactions, enhanced TNF-α synthesis and intense migration of activated macrophages, CD4(+) and CD8(+) T cells into the lungs. By week 10, iNOS(-/-) mice showed increased fungal burdens circumscribed, however, by compact granulomas containing elevated numbers of activated CD4(+) T cells. Importantly, the enhanced immunological reactivity of iNOS(-/-) mice resulted in decreased mortality rates. In both mouse strains, depletion of TNF-α led to non-organized lesions and excessive influx of inflammatory cells into the lungs, but only the iNOS(-/-) mice showed increased mortality rates. In addition, depletion of CD8(+) cells abolished the increased migration of inflammatory cells and decreased the number of TNF-α and IFN-γ CD4(+) and CD8(+) T cells into the lungs of iNOS(-/-) mice.Our study demonstrated that NO plays a deleterious role in pulmonary paracoccidioidomycosis due to its suppressive action on TNF-α production, T cell immunity and organization of lesions resulting in precocious mortality of mice. It was also revealed that uncontrolled fungal growth can be overcome by an efficient immune response." @default.
• W2017607536 created "2016-06-24" @default.
• W2017607536 creator A5007599550 @default.
• W2017607536 creator A5018994244 @default.
• W2017607536 creator A5025924020 @default.
• W2017607536 creator A5029646922 @default.
• W2017607536 creator A5034298070 @default.
• W2017607536 creator A5058060012 @default.
• W2017607536 creator A5074705375 @default.
• W2017607536 creator A5078481600 @default.
• W2017607536 creator A5082810834 @default.
• W2017607536 creator A5090159186 @default.
• W2017607536 date "2013-08-01" @default.
• W2017607536 modified "2023-10-18" @default.
• W2017607536 title "TNF-α and CD8+ T Cells Mediate the Beneficial Effects of Nitric Oxide Synthase-2 Deficiency in Pulmonary Paracoccidioidomycosis" @default.
• W2017607536 cites W1500951122 @default.
• W2017607536 cites W1560571961 @default.
• W2017607536 cites W1566128266 @default.
• W2017607536 cites W1574316486 @default.
• W2017607536 cites W1593552847 @default.
• W2017607536 cites W1644593521 @default.
• W2017607536 cites W1802820735 @default.
• W2017607536 cites W1807271190 @default.
• W2017607536 cites W184255300 @default.
• W2017607536 cites W1902026070 @default.
• W2017607536 cites W1903933791 @default.
• W2017607536 cites W1955881849 @default.
• W2017607536 cites W1958654148 @default.
• W2017607536 cites W1969595713 @default.
• W2017607536 cites W1974930528 @default.
• W2017607536 cites W1979230311 @default.
• W2017607536 cites W1982984484 @default.
• W2017607536 cites W2009902181 @default.
• W2017607536 cites W2019428230 @default.
• W2017607536 cites W2026570714 @default.
• W2017607536 cites W2027275036 @default.
• W2017607536 cites W2028174725 @default.
• W2017607536 cites W2032686335 @default.
• W2017607536 cites W2038992843 @default.
• W2017607536 cites W2040482361 @default.
• W2017607536 cites W2041306914 @default.
• W2017607536 cites W2042123178 @default.
• W2017607536 cites W2048884877 @default.
• W2017607536 cites W2063584856 @default.
• W2017607536 cites W2065006357 @default.
• W2017607536 cites W2065791817 @default.
• W2017607536 cites W2068598791 @default.
• W2017607536 cites W2068834630 @default.
• W2017607536 cites W2074025721 @default.
• W2017607536 cites W2074387820 @default.
• W2017607536 cites W2086592423 @default.
• W2017607536 cites W2093514245 @default.
• W2017607536 cites W2094370390 @default.
• W2017607536 cites W2095464441 @default.
• W2017607536 cites W2102472414 @default.
• W2017607536 cites W2102520038 @default.
• W2017607536 cites W2108244474 @default.
• W2017607536 cites W2108940390 @default.
• W2017607536 cites W2117583701 @default.
• W2017607536 cites W2120620942 @default.
• W2017607536 cites W2122515902 @default.
• W2017607536 cites W2125176044 @default.
• W2017607536 cites W2128049766 @default.
• W2017607536 cites W2130652971 @default.
• W2017607536 cites W2135201527 @default.
• W2017607536 cites W2135423586 @default.
• W2017607536 cites W2144667189 @default.
• W2017607536 cites W2149200346 @default.
• W2017607536 cites W2151371305 @default.
• W2017607536 cites W2157220006 @default.
• W2017607536 cites W2157477087 @default.
• W2017607536 cites W2158481318 @default.
• W2017607536 cites W2164004338 @default.
• W2017607536 cites W2169368610 @default.
• W2017607536 cites W2304510420 @default.
• W2017607536 cites W2409663795 @default.
• W2017607536 cites W4211001802 @default.
• W2017607536 cites W4313324526 @default.
• W2017607536 cites W4313376846 @default.
• W2017607536 cites W4322388291 @default.
• W2017607536 doi "https://doi.org/10.1371/journal.pntd.0002325" @default.
• W2017607536 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3731220" @default.
• W2017607536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23936574" @default.
• W2017607536 hasPublicationYear "2013" @default.
• W2017607536 type Work @default.
• W2017607536 sameAs 2017607536 @default.
• W2017607536 citedByCount "21" @default.
• W2017607536 countsByYear W20176075362014 @default.
• W2017607536 countsByYear W20176075362015 @default.
• W2017607536 countsByYear W20176075362016 @default.
• W2017607536 countsByYear W20176075362017 @default.
• W2017607536 countsByYear W20176075362019 @default.
• W2017607536 countsByYear W20176075362021 @default.
• W2017607536 countsByYear W20176075362022 @default.
• W2017607536 countsByYear W20176075362023 @default.
• W2017607536 crossrefType "journal-article" @default.
• W2017607536 hasAuthorship W2017607536A5007599550 @default.
• W2017607536 hasAuthorship W2017607536A5018994244 @default.

• next