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- W2017610913 abstract "Neonatal diabetes (ND) is defined as persistent hyperglycemia in the first 3 months of life (1). Heterozygous—usually autosomal-dominant—activating mutations in KCNJ11 , which encode the Kir6.2 subunit of the ATP-potassium (KATP) channel, cause the majority of cases (2). Sulfonylureas close the KATP channel by an ATP independent route (2).A 25-year-old Bangladeshi woman with type 1 diabetes gave birth to a baby girl. The mother had been on insulin for more than 20 years with inadequate glycemic control but never ketoacidosis. The baby was small for gestational age (2.4 kg, <3%). On day 2 of her life, the baby was noted to be increasingly hyperglycemic, reaching 312 mg/dL by day 7. Given the clinical suspicion for ND, a trial of glyburide was initiated at 0.45 mg/kg/day, and the baby responded well. The …" @default.
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- W2017610913 date "2012-07-14" @default.
- W2017610913 modified "2023-09-25" @default.
- W2017610913 title "The Diagnosis of Neonatal Diabetes in a Mother at 25 Years of Age" @default.
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