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• W2017612876 abstract "We describe a patient with acute myeloid leukemia (AML) who had a deletion of chromosome 22 at q11 as a sole chromosomal abnormality, resulting in the karyotype 46,XY,del(22)(q11). Southern blot analysis showed no bcr rearrangement and fluorescence in situ hybridization indicated no juxtaposition of c-abl. This study indicates that molecular events other than bcr rearrangement and c-abl juxtaposition were involved in leukemogenesis in this patient. We hypothesize that a tumor suppressor candidate gene may be located on the long arm of chromosome 22; its loss may lead to malignant transformation." @default.
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• W2017612876 date "1993-06-01" @default.
• W2017612876 modified "2023-09-27" @default.
• W2017612876 title "Deletion of chromosome 22 without bcr rearrangement and without juxtaposition of c-abl in a case of acute myeloid leukemia" @default.
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• W2017612876 doi "https://doi.org/10.1016/0165-4608(93)90168-l" @default.
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