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- W2017616523 abstract "Transcriptional dysregulation is now thought to be a common feature of polyglutamine disorders, including the spinocerebellar ataxias (SCAs). However, the precise causes of transcriptional alterations and how they relate to the observed phenotype remain elusive. Transcriptional impairment differs in different diseases, possibly reflecting the specific functions of the disease-causing proteins. The SCA7 gene product, ataxin-7, is a subunit of a transcriptional coactivator complex (called STAGA or TFTC) that has histone acetyltransferase activity. Studies on the effect of mutant ataxin-7 on STAGA function suggest that chromatin remodeling and transcriptional alterations are key pathologic events in SCA type 7. These studies could reveal how polyglutamine expansions alter the transcriptional regulation of genes required for neuronal function. Transcriptional dysregulation is now thought to be a common feature of polyglutamine disorders, including the spinocerebellar ataxias (SCAs). However, the precise causes of transcriptional alterations and how they relate to the observed phenotype remain elusive. Transcriptional impairment differs in different diseases, possibly reflecting the specific functions of the disease-causing proteins. The SCA7 gene product, ataxin-7, is a subunit of a transcriptional coactivator complex (called STAGA or TFTC) that has histone acetyltransferase activity. Studies on the effect of mutant ataxin-7 on STAGA function suggest that chromatin remodeling and transcriptional alterations are key pathologic events in SCA type 7. These studies could reveal how polyglutamine expansions alter the transcriptional regulation of genes required for neuronal function." @default.
- W2017616523 created "2016-06-24" @default.
- W2017616523 creator A5017404099 @default.
- W2017616523 creator A5030872396 @default.
- W2017616523 creator A5061782826 @default.
- W2017616523 date "2006-10-01" @default.
- W2017616523 modified "2023-10-18" @default.
- W2017616523 title "Transcriptional alterations and chromatin remodeling in polyglutamine diseases" @default.
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- W2017616523 doi "https://doi.org/10.1016/j.tig.2006.07.010" @default.
- W2017616523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16911843" @default.
- W2017616523 hasPublicationYear "2006" @default.