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• W2017617107 abstract "Adenylate cyclase activity and its modulation by guanine nucleotides and isoproterenol were assessed in adipocyte membranes of mice with mutations causing different genetic obesity syndromes. The object was to determine whether the defect in inhibitory modulation observed in the obese (ob/ob) mouse was also present in the diabetes (db/db) mouse. The data show that adipocyte adenylate cyclase in both the ob/ob and the db/db mouse is resistant to activation by isoproterenol. The response to guanosine triphosphate (GTP) differed between the two mutants, such that an inhibitory phase was visible in the db/db but not in the ob/ob membranes. Moreover, pertussis toxin attenuated the inhibitory effect of GTP and significantly stimulated cyclase activity in the db/db but not in the ob/ob membranes. The data show that the two mutations affect the expression of adenylate cyclase activity via different mechanisms." @default.
• W2017617107 created "2016-06-24" @default.
• W2017617107 creator A5007451022 @default.
• W2017617107 creator A5009769588 @default.
• W2017617107 date "1988-10-01" @default.
• W2017617107 modified "2023-10-18" @default.
• W2017617107 title "Effect of the genetic background and specific mutation on adenylate cyclase activity in obesity syndromes" @default.
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• W2017617107 doi "https://doi.org/10.1016/0303-7207(88)90101-3" @default.
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