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• W2017620090 abstract "Sodium acetate-catalyzed multicomponent reaction of salicylaldehydes, malononitrile and 3-methyl-2-pyrazolin-5-one initiated by grinding in mortar in the presence of small quantities of water results in the fast (10 min) and efficient formation of substituted 2-amino-4-(1H-pyrazol-4-yl)-4H-chromenes in 90–96% yields. The developed fast and efficient approach to the substituted 2-amino-4-(1H-pyrazol-4-yl)-4H-chromenes – the promising small-molecule ligands for the treatment of human inflammatory TNFα-mediated diseases and different biomedical applications –, is beneficial from the viewpoint of diversity-oriented large-scale processes and represents fast, efficient and environmentally benign synthetic concept for multicomponent reactions strategy." @default.
• W2017620090 created "2016-06-24" @default.
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• W2017620090 date "2014-05-01" @default.
• W2017620090 modified "2023-10-18" @default.
• W2017620090 title "Solvent-free and ‘on-water’ multicomponent assembling of salicylaldehydes, malononitrile and 3-methyl-2-pyrazolin-5-one: A fast and efficient route to the 2-amino-4-(1H-pyrazol-4-yl)-4H-chromene scaffold" @default.
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• W2017620090 doi "https://doi.org/10.1016/j.crci.2013.08.002" @default.
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