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• W2017621543 abstract "TO THE EDITOR: We read with interest the review article by Lee et al1 regarding “Clinical characteristics and treatment outcomes of 3 subtypes of achalasia according to the Chicago classification in a tertiary institute in Korea.” The study showed that type II achalasia (n = 28 [50.9%]) is the most common subtype followed by type I (n = 21 [38.2%]) and type III (n = 6 [10.9%]). Interestingly, all type III patients responded to calcium channel blocker in the study. The authors suggested that type III should be a different entity from those of type I and II. We strongly agree with their opinion. We have been evaluating patients with suspected achalasia using high-resolution manometry (HRM) with special interest for 5 years. To our experience, the definition of achalasia according to “Chicago classification of HRM” is not perfect. We have experienced achalasia patients with normal integrated relaxation pressure (IRP). As one example, a 12-year-old female who began to experience dysphagia for solid food approximately 2 months before presentation. Physical examination did not reveal signs of scleroderma. Upper endoscopy revealed esophageal dilatation with retained secretion and food material (Fig. 1A and ​and1B).1B). A barium esophagogram showed severe disturbance in emptying into the stomach (Fig. 1C). HRM at sitting position showed aperistalsis with normal 4 second-IRP (normal range < 15 mmHg) (Fig. 1D). Eckardt score at that time was 5. Based on this constellation of data, the patient was diagnosed with achalasia, and underwent peroral endoscopic myotomy. On follow-up at 6 months, she was free of dysphagia, and upper endoscopy revealed unremarkable findings except for scar changes at the site of the mucosal entrance (Fig. 2A and ​and2B).2B). Barium esophagography showed free flow of contrast from the esophagus to the stomach (Fig. 2C). HRM showed weak peristalsis with large peristaltic defects (Fig. 2D).Figure 1.Clinical findings of a 12-year-old female with solid dysphagia. (A) Upper endoscopy shows dilated esophagus and retained food material. (B) Lower esophageal sphincter is not opened with air inflation. (C) Esophageal dilatation with bird-beak narrowing ...Figure 2.The clinical findings of follow-up at 6 months after peroral endoscopic myotomy. (A) Upper endoscopy shows opened lower esophageal sphincter. (B) A scar is visible at the site of the mucosal entrance. (C) Barium esophagogram shows free flow of contrast ...The Chicago classification is challenged by this case of achalasia with normal IRP. In fact, we have experienced 4 patients with achalasia, who were similar to this case. These findings suggested that normal IRP does not preclude a diagnosis of achalasia. Refining the IRP should be needed especially in patients with low lower esophageal sphincter (LES) pressure, although the sitting position might contribute to these atypical findings. Earlier studies of conventional manometry demonstrated that a subset of achalasia patients had apparently normal LES relaxation.2–5 In the past, one plausible explanation for the reason is that it represents an artifact from the movement of manometry catheter. In the era of HRM, the achalasia cases with normal LES relaxation (ie normal IRP) can not be explained by the artifact associated with catheter movement. The findings of achalasia with normal IRP also raise a number of issues regarding the etiopathogenesis of achalasia. The findings might be a representative of an early phase of the achalasia. The relatively short period follow-up (2 months) may support this possible explanation. Interestingly, this case showed transition from achalasia to weak peristalsis after treatment. In conclusion, we should know the significance in the heterogeneity of achalasia, that is not addressed by current “Chicago classification of HRM.”" @default.
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• W2017621543 date "2015-01-01" @default.
• W2017621543 modified "2023-10-16" @default.
• W2017621543 title "Chicago Classification Should Be Challenged in the Diagnosis of Achalasia: Heterogeneity of Achalasia" @default.
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• W2017621543 doi "https://doi.org/10.5056/jnm14094" @default.
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