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- W2017621739 abstract "The purpose of this retrospective analysis of DR-in-compatible cadaver renal transplantation was to evaluate the effect of HLA A and B matching and blood transfusion status on actual one-year graft survival. There were 31 2-DR, 111 1-DR, and 27 0-DR grafts at risk during the study period. First, a comparison was made between preoperative (PRE) and peroperative (PER) transfusions alone. Graft survivals were 70% vs. 92% (2 DR), 67% vs. 52% (1 DR) and 71% vs. 39% (0 DR) for the PRE and PER groups, respectively. Statistical significance was not found between the two values in each DR subgroup, although the difference approached significance in the 0 DR group (0.1>P>0.05). Matching for ≥2 A and B antigens significantly improved graft survival in the 1 DR-matched group when compared with those matched for <2 antigens (76% vs. 44%, P<0.005). While marked differences between the ≥2 and <2 A and B matched groups were observed for both the 2 DR (92% vs. 68%, P>0.1) and 0 DR groups (59% vs. 40%, P>0.3) these differences were not significant. Stratifying the data for transfusion status revealed that the positive influence of HLA A and B matching in the 1 DR group was dependent upon the presence of preoperative blood administration. Graft survival of 87% for the PRE transfused recipients of grafts matched for ≥2 A and B antigens was significantly better (P<0.001) than the 42% survival observed in similarly transfused recipients of poorer matched organs. Conversely, A and B matching was not significantly beneficial in the 1 DR recipients transfused only at the time of transplant with graft survivals of 57% vs. 43% for those matched for ≥2 or < 2 A and B antigens, respectively (P>0.3). This analysis suggests that a combined effect of both HLA A and B matching and preoperative blood transfusions may allow for highly successful first cadaver renal transplantation in the face of DR incompatibility." @default.
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- W2017621739 date "1984-12-01" @default.
- W2017621739 modified "2023-09-27" @default.
- W2017621739 title "SUCCESSFUL DR-INCOMPATIBLE CADAVER KIDNEY TRANSPLANTATION" @default.
- W2017621739 doi "https://doi.org/10.1097/00007890-198412000-00020" @default.
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