Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017622860> ?p ?o ?g. }
- W2017622860 endingPage "136" @default.
- W2017622860 startingPage "127" @default.
- W2017622860 abstract "In Trypanosoma cruzi a cell surface enzyme with trans-sialidase (TS) activity has been implicated as an important factor in establishing infection. The enzyme is encoded by genes belonging to a large super-family which on the basis of sequence has been subdivided into 4 groups. TS mediates the transfer of sialic acid residues from host glycoconjugates to acceptor molecules on the parasite surface. To study the organisation of the TS genes we isolated several distinct cosmids from a library constructed with DNA from the T. cruzi X10.6 clone. In these cosmids, the TS genes (group I) were present either as single copies or as a direct tandem repeat. A common feature of the cosmids was the presence of a related group III gene located 10–12kb downstream of the TS gene(s) and arranged in the same orientation. In several of the cosmids we also identified a mucin-like glycoprotein gene located between the group I and group III genes. The mucin-like genes are part of a large polymorphic family and contour clamped homogeneous electric field electrophoresis (CHEFE) analysis showed that they were linked to members of the TS super-family at multiple sites in the X10.6 genome. Screening of a second cosmid library made with DNA from the CL-Brener clone confirmed this multiple linkage suggesting that it is a common feature of the species. This genetic organisation may have important functional significance since the mucin-like glycoproteins are the major cell surface acceptors of sialic acid." @default.
- W2017622860 created "2016-06-24" @default.
- W2017622860 creator A5037122179 @default.
- W2017622860 creator A5069753335 @default.
- W2017622860 creator A5078818705 @default.
- W2017622860 date "1996-06-01" @default.
- W2017622860 modified "2023-09-23" @default.
- W2017622860 title "Mucin-like glycoprotein genes are closely linked to members of the trans-sialidase super-family at multiple sites in the Trypanosoma cruzi genome" @default.
- W2017622860 cites W1126976477 @default.
- W2017622860 cites W1494475493 @default.
- W2017622860 cites W1494626566 @default.
- W2017622860 cites W1509884282 @default.
- W2017622860 cites W1564186526 @default.
- W2017622860 cites W1570729505 @default.
- W2017622860 cites W1574167776 @default.
- W2017622860 cites W1580259448 @default.
- W2017622860 cites W1589735909 @default.
- W2017622860 cites W1875892240 @default.
- W2017622860 cites W1924186013 @default.
- W2017622860 cites W1940901679 @default.
- W2017622860 cites W1970973247 @default.
- W2017622860 cites W1971932668 @default.
- W2017622860 cites W1983242241 @default.
- W2017622860 cites W1995277355 @default.
- W2017622860 cites W1997263031 @default.
- W2017622860 cites W2002534697 @default.
- W2017622860 cites W2005442970 @default.
- W2017622860 cites W2010530746 @default.
- W2017622860 cites W2011097800 @default.
- W2017622860 cites W2012524737 @default.
- W2017622860 cites W2054259484 @default.
- W2017622860 cites W2057327068 @default.
- W2017622860 cites W2074360792 @default.
- W2017622860 cites W2076215130 @default.
- W2017622860 cites W2087920981 @default.
- W2017622860 cites W2092527492 @default.
- W2017622860 cites W2092912450 @default.
- W2017622860 cites W2105879148 @default.
- W2017622860 cites W2114168982 @default.
- W2017622860 cites W2115372664 @default.
- W2017622860 cites W2129181111 @default.
- W2017622860 cites W2138931722 @default.
- W2017622860 cites W2144634347 @default.
- W2017622860 cites W2147329444 @default.
- W2017622860 cites W2151091196 @default.
- W2017622860 cites W2158297972 @default.
- W2017622860 cites W2161594864 @default.
- W2017622860 cites W2175428614 @default.
- W2017622860 cites W2414324517 @default.
- W2017622860 cites W610062301 @default.
- W2017622860 doi "https://doi.org/10.1016/s0166-6851(96)02617-5" @default.
- W2017622860 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8813683" @default.
- W2017622860 hasPublicationYear "1996" @default.
- W2017622860 type Work @default.
- W2017622860 sameAs 2017622860 @default.
- W2017622860 citedByCount "21" @default.
- W2017622860 countsByYear W20176228602013 @default.
- W2017622860 crossrefType "journal-article" @default.
- W2017622860 hasAuthorship W2017622860A5037122179 @default.
- W2017622860 hasAuthorship W2017622860A5069753335 @default.
- W2017622860 hasAuthorship W2017622860A5078818705 @default.
- W2017622860 hasConcept C104317684 @default.
- W2017622860 hasConcept C108625454 @default.
- W2017622860 hasConcept C13575015 @default.
- W2017622860 hasConcept C141231307 @default.
- W2017622860 hasConcept C153911025 @default.
- W2017622860 hasConcept C167625842 @default.
- W2017622860 hasConcept C2780115458 @default.
- W2017622860 hasConcept C35101798 @default.
- W2017622860 hasConcept C54355233 @default.
- W2017622860 hasConcept C5911399 @default.
- W2017622860 hasConcept C86803240 @default.
- W2017622860 hasConceptScore W2017622860C104317684 @default.
- W2017622860 hasConceptScore W2017622860C108625454 @default.
- W2017622860 hasConceptScore W2017622860C13575015 @default.
- W2017622860 hasConceptScore W2017622860C141231307 @default.
- W2017622860 hasConceptScore W2017622860C153911025 @default.
- W2017622860 hasConceptScore W2017622860C167625842 @default.
- W2017622860 hasConceptScore W2017622860C2780115458 @default.
- W2017622860 hasConceptScore W2017622860C35101798 @default.
- W2017622860 hasConceptScore W2017622860C54355233 @default.
- W2017622860 hasConceptScore W2017622860C5911399 @default.
- W2017622860 hasConceptScore W2017622860C86803240 @default.
- W2017622860 hasIssue "1-2" @default.
- W2017622860 hasLocation W20176228601 @default.
- W2017622860 hasLocation W20176228602 @default.
- W2017622860 hasOpenAccess W2017622860 @default.
- W2017622860 hasPrimaryLocation W20176228601 @default.
- W2017622860 hasRelatedWork W113565669 @default.
- W2017622860 hasRelatedWork W1573987240 @default.
- W2017622860 hasRelatedWork W1969650636 @default.
- W2017622860 hasRelatedWork W1971007533 @default.
- W2017622860 hasRelatedWork W2044720815 @default.
- W2017622860 hasRelatedWork W2069184423 @default.
- W2017622860 hasRelatedWork W2407212450 @default.
- W2017622860 hasRelatedWork W2518774397 @default.
- W2017622860 hasRelatedWork W4315640719 @default.
- W2017622860 hasRelatedWork W2187207551 @default.