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• W2017629813 abstract "Stimuli such as water deprivation or salt loading which induce the secretion and synthesis of the neurohypophysial hormones also induce ‘activation’ of the glial cells (pituicytes) surrounding the neurosecretory axonal fibers and terminals in the neural lobe. It has been show that this is expressed in part by the ability of neural lobes from stimulated rats to shown an enhanced in vitro incorporation of [ 3 H]uridine into total RNA extracted by alkaline hydrolysis. In order to characterize the newly synthesized RNAs, quantitative and reproducible methods were developed for the selective extraction and fractionation on glycerol gradients of microgram amounts of pulse-labeled RNA from neural tissues. These methods were applied in comparative studies on the RNA labeling patterns of cerebral cortex and of neural lobes pulsed in vivo and in vitro respectively with [ 3 H]uridine and [ 32 P]orthophosphate. In the former case, analysis of the RNA labeling profiles at various time periods, indicate that in the brain as in many eukaryotic cells, there is 45S precursor-28S and 18S product relationship; a 36–38S RNA appears to be a major component in the transformation of the 45S molecules to 32S RNA. Similar results were obtained in studies in which neural lobes from control and stimulated rats were pulsed in vitro with the above isotopic compounds. Furthermore, the dehydration stimulus resulted in both a generalized and a selective increase in the labelling of the various RNA species. This stimulated incorporation of [ 3 H]uridine or [ 32 P]orthophosphate into RNA was not uniform across the gradient and distinct differences in the pattern of labeling could be discerned. The greatest differences ( i.e increase over control) were observed in the high molecular weight species and were apparent depending upon the RNA extraction procedure and the labeling period." @default.
• W2017629813 created "2016-06-24" @default.
• W2017629813 creator A5009690635 @default.
• W2017629813 creator A5062961182 @default.
• W2017629813 date "1972-11-01" @default.
• W2017629813 modified "2023-09-23" @default.
• W2017629813 title "Fractionation of RNA of the rat neural lobe labeledin vitro: Comparison with RNA of cerebral cortex labeledin vivo" @default.
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• W2017629813 doi "https://doi.org/10.1016/0006-8993(72)90264-8" @default.
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