Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017638348> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2017638348 endingPage "19" @default.
- W2017638348 startingPage "8" @default.
- W2017638348 abstract "The mechanism of selenocysteine insertion into proteins is distinct from all other amino acids in all lines of descent in that it needs specific protein cofactors and a structurally unique tRNASec. It is first aminoacylated with serine and further recognized among all other serylated serine isoacceptors by a selenocysteine synthase and is converted to selenocysteyl-tRNASecWe present here the complete set of identity elements for selenylation of mammalian seryl-tRNASecand show that the transplantation of these elements into normal serine tRNA allows its selenylation. Four particular structural motifs differentiate eukaryotic tRNASecfrom normal tRNASer: the orientation of the extra arm, the short 4 bp TΨC-stem, the extra long 9 bp acceptor-stem and the elongated 6 bp dihydrouridine-stem. Only the last two are essential and only together sufficient for selenocysteine synthesis, whereby the additional base-pairs of the acceptor-stem may be replaced by non-paired nucleotides. Each exchange of the first three structural motifs mentioned above between tRNASerand tRNASecresulted in a significant loss of serylation, indicating that the overall composition of particular structure elements is necessary to maintain normal functions of tRNASec. Since we find that all seryl-tRNAs which are selenylated are also substrates for serine phosphorylation we propose that phosphoseryl- tRNASecis a storage form of seryl-tRNASec." @default.
- W2017638348 created "2016-06-24" @default.
- W2017638348 creator A5001776641 @default.
- W2017638348 creator A5057439115 @default.
- W2017638348 creator A5061484505 @default.
- W2017638348 creator A5068659922 @default.
- W2017638348 date "1996-10-01" @default.
- W2017638348 modified "2023-10-05" @default.
- W2017638348 title "Selenocysteine Synthesis in Mammalia: An Identity Switch From tRNASerto tRNASec" @default.
- W2017638348 doi "https://doi.org/10.1006/jmbi.1996.0552" @default.
- W2017638348 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8890909" @default.
- W2017638348 hasPublicationYear "1996" @default.
- W2017638348 type Work @default.
- W2017638348 sameAs 2017638348 @default.
- W2017638348 citedByCount "60" @default.
- W2017638348 countsByYear W20176383482012 @default.
- W2017638348 countsByYear W20176383482013 @default.
- W2017638348 countsByYear W20176383482015 @default.
- W2017638348 countsByYear W20176383482016 @default.
- W2017638348 countsByYear W20176383482017 @default.
- W2017638348 countsByYear W20176383482020 @default.
- W2017638348 countsByYear W20176383482022 @default.
- W2017638348 crossrefType "journal-article" @default.
- W2017638348 hasAuthorship W2017638348A5001776641 @default.
- W2017638348 hasAuthorship W2017638348A5057439115 @default.
- W2017638348 hasAuthorship W2017638348A5061484505 @default.
- W2017638348 hasAuthorship W2017638348A5068659922 @default.
- W2017638348 hasConcept C104317684 @default.
- W2017638348 hasConcept C11960822 @default.
- W2017638348 hasConcept C153957851 @default.
- W2017638348 hasConcept C181199279 @default.
- W2017638348 hasConcept C185592680 @default.
- W2017638348 hasConcept C2775880066 @default.
- W2017638348 hasConcept C2776087148 @default.
- W2017638348 hasConcept C2776414213 @default.
- W2017638348 hasConcept C2779201268 @default.
- W2017638348 hasConcept C512185932 @default.
- W2017638348 hasConcept C55493867 @default.
- W2017638348 hasConcept C67705224 @default.
- W2017638348 hasConcept C86803240 @default.
- W2017638348 hasConceptScore W2017638348C104317684 @default.
- W2017638348 hasConceptScore W2017638348C11960822 @default.
- W2017638348 hasConceptScore W2017638348C153957851 @default.
- W2017638348 hasConceptScore W2017638348C181199279 @default.
- W2017638348 hasConceptScore W2017638348C185592680 @default.
- W2017638348 hasConceptScore W2017638348C2775880066 @default.
- W2017638348 hasConceptScore W2017638348C2776087148 @default.
- W2017638348 hasConceptScore W2017638348C2776414213 @default.
- W2017638348 hasConceptScore W2017638348C2779201268 @default.
- W2017638348 hasConceptScore W2017638348C512185932 @default.
- W2017638348 hasConceptScore W2017638348C55493867 @default.
- W2017638348 hasConceptScore W2017638348C67705224 @default.
- W2017638348 hasConceptScore W2017638348C86803240 @default.
- W2017638348 hasIssue "1" @default.
- W2017638348 hasLocation W20176383481 @default.
- W2017638348 hasLocation W20176383482 @default.
- W2017638348 hasOpenAccess W2017638348 @default.
- W2017638348 hasPrimaryLocation W20176383481 @default.
- W2017638348 hasRelatedWork W100133296 @default.
- W2017638348 hasRelatedWork W175432153 @default.
- W2017638348 hasRelatedWork W1977482452 @default.
- W2017638348 hasRelatedWork W1979428706 @default.
- W2017638348 hasRelatedWork W1986485457 @default.
- W2017638348 hasRelatedWork W2019661979 @default.
- W2017638348 hasRelatedWork W2072767450 @default.
- W2017638348 hasRelatedWork W2084389954 @default.
- W2017638348 hasRelatedWork W2138025507 @default.
- W2017638348 hasRelatedWork W2326439745 @default.
- W2017638348 hasVolume "263" @default.
- W2017638348 isParatext "false" @default.
- W2017638348 isRetracted "false" @default.
- W2017638348 magId "2017638348" @default.
- W2017638348 workType "article" @default.