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- W2017641307 abstract "The effects of the flavonoid phloretin on K+ channels in amphibian myelinated nerve were studied by patch clamping. The open probability of Ca(2+)-activated K+ channels was greatly increased by external phloretin (10-200 microM) due to a shift of the membrane potential for half-maximal activation, E50, of -63.9 mV (80 microM phloretin). Open times were prolonged and closed times shortened. Channel activation by phloretin developed slowly (tau on = 33.4 s) and its washout was even slower (tau off,1 = 4.7 and tau off,2 = 183.2 s). In contrast, submillimolar phloretin blocked two delayed rectifier K+ channels (I and F) whereas the gating of the ATP-sensitive and the flickering K+ channel were unaffected. Phloretin may directly affect the voltage sensor of K+ channels." @default.
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- W2017641307 title "Effect of the flavoid phloretin on Ca2+-activated K+ channels in myelinated nerve fibres of Xenopus laevis" @default.
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- W2017641307 doi "https://doi.org/10.1016/0304-3940(94)90736-6" @default.
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