Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017641518> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2017641518 abstract "Treatment with inhaled corticosteroids improves symptoms and reduces bronchial hyperresponsiveness (BHR) associated with asthma. Delivery of drugs into the lung is dependent on the inhaler device. Furthermore, environmental concerns regarding the use of chlorofluorocarbon propellants in pressurised inhalers and patient acceptability of inhaler devices both influence the extent of use of different delivery systems.To compare the efficacy of beclomethasone dipropionate (BDP) administered via a novel multidose dry-powder inhaler (DPI) and a conventional pressurised metered-dose inhaler (pMDI) with spacer in patients with BHR.A randomised, double-blind, crossover study was carried out in a group of 27 patients (aged 19-55 years) with a clinical diagnosis of reversible airway disease, who demonstrated BHR to methacholine (PD(20) < or =6.4 mg). Each patient received BDP (< or =2 mg/day) via the DPI or pMDI, for periods of 4 weeks. The randomised treatment periods were preceded by 3-week washout periods when no corticosteroid was used. Five clinic visits marked the start and end of each study phase. The primary efficacy endpoint was BHR as defined by the pharmacodynamic parameter, PD(20), which was determined at the start and end of each treatment period. Clinical endpoints including lung function, symptoms and adverse events were also evaluated.Both treatments caused a significant decrease in BHR (p<0.05 vs. pre-treatment values). Mean +/- SD changes in log PD(20) were: DPI 0.59+/-1.29; pMDI 0.59+/-0.94 mg. There was no statistically significant difference between treatments and no evidence of a carry-over effect between treatments on BHR. Clinical efficacy and safety parameters also demonstrated no statistically significant treatment differences, and patients found the DPI easier to use.Efficacy of BDP in reducing BHR is comparable via the DPI and pMDI plus spacer." @default.
- W2017641518 created "2016-06-24" @default.
- W2017641518 creator A5006027447 @default.
- W2017641518 creator A5009269090 @default.
- W2017641518 creator A5038285954 @default.
- W2017641518 date "2000-01-01" @default.
- W2017641518 modified "2023-09-26" @default.
- W2017641518 title "Comparison of the Effect on Bronchial Hyperresponsiveness of Beclomethasone Dipropionate Administered via a Novel Multidose Dry-Powder Inhaler or a Conventional Pressurised Metered Dose Inhaler" @default.
- W2017641518 cites W121149184 @default.
- W2017641518 cites W175715090 @default.
- W2017641518 cites W1966971246 @default.
- W2017641518 cites W1992867264 @default.
- W2017641518 cites W2005861503 @default.
- W2017641518 cites W2008742573 @default.
- W2017641518 cites W2020874051 @default.
- W2017641518 cites W2031867711 @default.
- W2017641518 cites W2055893705 @default.
- W2017641518 cites W2077015041 @default.
- W2017641518 cites W2077679009 @default.
- W2017641518 cites W2109652900 @default.
- W2017641518 cites W2122956855 @default.
- W2017641518 cites W2139994266 @default.
- W2017641518 cites W2166478165 @default.
- W2017641518 cites W2427433614 @default.
- W2017641518 cites W2602842300 @default.
- W2017641518 doi "https://doi.org/10.1159/000029514" @default.
- W2017641518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10867599" @default.
- W2017641518 hasPublicationYear "2000" @default.
- W2017641518 type Work @default.
- W2017641518 sameAs 2017641518 @default.
- W2017641518 citedByCount "10" @default.
- W2017641518 crossrefType "journal-article" @default.
- W2017641518 hasAuthorship W2017641518A5006027447 @default.
- W2017641518 hasAuthorship W2017641518A5009269090 @default.
- W2017641518 hasAuthorship W2017641518A5038285954 @default.
- W2017641518 hasConcept C126322002 @default.
- W2017641518 hasConcept C2776042228 @default.
- W2017641518 hasConcept C2776178081 @default.
- W2017641518 hasConcept C2776238763 @default.
- W2017641518 hasConcept C2776954882 @default.
- W2017641518 hasConcept C2777419714 @default.
- W2017641518 hasConcept C2777714996 @default.
- W2017641518 hasConcept C2777992530 @default.
- W2017641518 hasConcept C2780261241 @default.
- W2017641518 hasConcept C2780667556 @default.
- W2017641518 hasConcept C42219234 @default.
- W2017641518 hasConcept C71924100 @default.
- W2017641518 hasConcept C98274493 @default.
- W2017641518 hasConceptScore W2017641518C126322002 @default.
- W2017641518 hasConceptScore W2017641518C2776042228 @default.
- W2017641518 hasConceptScore W2017641518C2776178081 @default.
- W2017641518 hasConceptScore W2017641518C2776238763 @default.
- W2017641518 hasConceptScore W2017641518C2776954882 @default.
- W2017641518 hasConceptScore W2017641518C2777419714 @default.
- W2017641518 hasConceptScore W2017641518C2777714996 @default.
- W2017641518 hasConceptScore W2017641518C2777992530 @default.
- W2017641518 hasConceptScore W2017641518C2780261241 @default.
- W2017641518 hasConceptScore W2017641518C2780667556 @default.
- W2017641518 hasConceptScore W2017641518C42219234 @default.
- W2017641518 hasConceptScore W2017641518C71924100 @default.
- W2017641518 hasConceptScore W2017641518C98274493 @default.
- W2017641518 hasLocation W20176415181 @default.
- W2017641518 hasLocation W20176415182 @default.
- W2017641518 hasOpenAccess W2017641518 @default.
- W2017641518 hasPrimaryLocation W20176415181 @default.
- W2017641518 hasRelatedWork W1986606700 @default.
- W2017641518 hasRelatedWork W2025861834 @default.
- W2017641518 hasRelatedWork W2054518635 @default.
- W2017641518 hasRelatedWork W2068807332 @default.
- W2017641518 hasRelatedWork W2130156739 @default.
- W2017641518 hasRelatedWork W2158554969 @default.
- W2017641518 hasRelatedWork W2292274087 @default.
- W2017641518 hasRelatedWork W2331252052 @default.
- W2017641518 hasRelatedWork W2727492120 @default.
- W2017641518 hasRelatedWork W2746096266 @default.
- W2017641518 hasRelatedWork W2755424308 @default.
- W2017641518 hasRelatedWork W2811403460 @default.
- W2017641518 hasRelatedWork W2991543388 @default.
- W2017641518 hasRelatedWork W3010921936 @default.
- W2017641518 hasRelatedWork W3041212865 @default.
- W2017641518 hasRelatedWork W3082760062 @default.
- W2017641518 hasRelatedWork W3148298926 @default.
- W2017641518 hasRelatedWork W3177560700 @default.
- W2017641518 hasRelatedWork W2620684441 @default.
- W2017641518 hasRelatedWork W2997878210 @default.
- W2017641518 isParatext "false" @default.
- W2017641518 isRetracted "false" @default.
- W2017641518 magId "2017641518" @default.
- W2017641518 workType "article" @default.