Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017643606> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2017643606 endingPage "186" @default.
- W2017643606 startingPage "182" @default.
- W2017643606 abstract "Reduction of amylin content and secretion in rat islets was attempted by transduction with an adenovirus bearing a 0.2-kb fragment of rat amylin cDNA inserted in the antisense orientation (AdCMV-alpha amylin). Exposure of islets to AdCMV-alpha amylin at a multiplicity of infection (moi) of 200 (1.2 x 10(7) pfu/ml) reduced amylin mRNA levels by 37 +/- 5% (p < 0.005), whereas infection with an adenovirus expressing the reporter gene of beta-galactosidase (AdCMV-lacz) did not modify amylin expression. Transduction with the antisense construct was specifically associated with the decrease (30 +/- 6%; p < 0.001) in the amylin content. Insulin content was unaltered in AdCMV-alpha amylin islets compared to AdCMV-lacz-transduced or untransduced cells. Basal amylin secretion (2.8 mM glucose) was 36 +/- 3% (p < 0.005) lower in AdCMV-alpha amylin islets than in untransduced or AdCMV-lacz-transduced islets. In contrast, no difference in amylin secretion in response to high glucose concentrations (16.7 mM) was detected in AdCMV-alpha amylin-transduced islets. Thus, a reduction of amylin content and basal secretion in islet cells can be achieved by the adenovirus-mediated expression of antisense RNA." @default.
- W2017643606 created "2016-06-24" @default.
- W2017643606 creator A5005534397 @default.
- W2017643606 creator A5033227904 @default.
- W2017643606 creator A5042538544 @default.
- W2017643606 creator A5059342143 @default.
- W2017643606 creator A5072254530 @default.
- W2017643606 creator A5080459428 @default.
- W2017643606 date "1998-08-01" @default.
- W2017643606 modified "2023-10-13" @default.
- W2017643606 title "Reduction of Islet Amylin Expression and Basal Secretion by Adenovirus-Mediated Delivery of Amylin Antisense cDNA" @default.
- W2017643606 doi "https://doi.org/10.1097/00006676-199808000-00012" @default.
- W2017643606 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9700951" @default.
- W2017643606 hasPublicationYear "1998" @default.
- W2017643606 type Work @default.
- W2017643606 sameAs 2017643606 @default.
- W2017643606 citedByCount "10" @default.
- W2017643606 countsByYear W20176436062016 @default.
- W2017643606 countsByYear W20176436062017 @default.
- W2017643606 countsByYear W20176436062022 @default.
- W2017643606 countsByYear W20176436062023 @default.
- W2017643606 crossrefType "journal-article" @default.
- W2017643606 hasAuthorship W2017643606A5005534397 @default.
- W2017643606 hasAuthorship W2017643606A5033227904 @default.
- W2017643606 hasAuthorship W2017643606A5042538544 @default.
- W2017643606 hasAuthorship W2017643606A5059342143 @default.
- W2017643606 hasAuthorship W2017643606A5072254530 @default.
- W2017643606 hasAuthorship W2017643606A5080459428 @default.
- W2017643606 hasConcept C126322002 @default.
- W2017643606 hasConcept C134018914 @default.
- W2017643606 hasConcept C153911025 @default.
- W2017643606 hasConcept C165220095 @default.
- W2017643606 hasConcept C2779306644 @default.
- W2017643606 hasConcept C2779855799 @default.
- W2017643606 hasConcept C2780705028 @default.
- W2017643606 hasConcept C71924100 @default.
- W2017643606 hasConcept C86803240 @default.
- W2017643606 hasConceptScore W2017643606C126322002 @default.
- W2017643606 hasConceptScore W2017643606C134018914 @default.
- W2017643606 hasConceptScore W2017643606C153911025 @default.
- W2017643606 hasConceptScore W2017643606C165220095 @default.
- W2017643606 hasConceptScore W2017643606C2779306644 @default.
- W2017643606 hasConceptScore W2017643606C2779855799 @default.
- W2017643606 hasConceptScore W2017643606C2780705028 @default.
- W2017643606 hasConceptScore W2017643606C71924100 @default.
- W2017643606 hasConceptScore W2017643606C86803240 @default.
- W2017643606 hasIssue "2" @default.
- W2017643606 hasLocation W20176436061 @default.
- W2017643606 hasLocation W20176436062 @default.
- W2017643606 hasOpenAccess W2017643606 @default.
- W2017643606 hasPrimaryLocation W20176436061 @default.
- W2017643606 hasRelatedWork W1925269365 @default.
- W2017643606 hasRelatedWork W1968759076 @default.
- W2017643606 hasRelatedWork W1999909300 @default.
- W2017643606 hasRelatedWork W2000607179 @default.
- W2017643606 hasRelatedWork W2140892006 @default.
- W2017643606 hasRelatedWork W2144574657 @default.
- W2017643606 hasRelatedWork W2748952813 @default.
- W2017643606 hasRelatedWork W2783111266 @default.
- W2017643606 hasRelatedWork W4293265234 @default.
- W2017643606 hasRelatedWork W4296503608 @default.
- W2017643606 hasVolume "17" @default.
- W2017643606 isParatext "false" @default.
- W2017643606 isRetracted "false" @default.
- W2017643606 magId "2017643606" @default.
- W2017643606 workType "article" @default.