Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017647546> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2017647546 endingPage "1379" @default.
- W2017647546 startingPage "1378" @default.
- W2017647546 abstract "Corticosteroids are a cornerstone of immunosuppressive therapy in renal transplantation despite their side effects and morbidity. Newer immunosuppressive agents may be more effective to allow corticosteroid sparing. An interim analysis of 60 completed out of 100 planned primary kidney transplant recipients is presented. All patients on tacrolimus (Prograf) and MMF (Cellcept) were randomized into two groups following a 1:1 distribution for early steroid reduction at posttransplant day 7 (G1; n = 31) versus to long-term maintenance steroids (G2; n = 29). Primary efficacy endpoints were composite endpoint of death, graft loss, or severe acute rejection at 6 and 12 months follow-up. Safety evaluation included severity and frequency of diabetes mellitus, hypertension, hyperlipidemia, leukopenia, infection, malignancy, and severe adverse events. Mean age was 39.1 years, with 45.0% males and 66.7% Caucasians. African-Americans were 25.8% in G1 and 27.6% in G2. One death occurred in each group, as well as one case of severe (Banff III) rejection in G1 (P = 1.00). The incidence of rejection episodes between groups was not significant, namely, 41.9% in G1 and 20.7% in G2 (P = .077). There were no differences between groups concerning mean, systolic and diastolic blood pressure, HbA1c, or creatinine at 12 months. This interim analysis showed no evidence of an increased risk of poorer performance among the early steroid reduction or safety differences in kidney transplant recipients versus a regular dosage steroid group of patients. Further analysis of the complete study data is underway." @default.
- W2017647546 created "2016-06-24" @default.
- W2017647546 creator A5015939109 @default.
- W2017647546 creator A5033262794 @default.
- W2017647546 creator A5035779290 @default.
- W2017647546 creator A5046333051 @default.
- W2017647546 creator A5048007683 @default.
- W2017647546 creator A5054506083 @default.
- W2017647546 creator A5060244960 @default.
- W2017647546 creator A5063832474 @default.
- W2017647546 creator A5066186322 @default.
- W2017647546 date "1998-06-01" @default.
- W2017647546 modified "2023-09-27" @default.
- W2017647546 title "Corticosteroid Cessation 1 Week Following Renal Transplantation Using Tacrolimus/Mycophenolate Mofetil Based Immunosuppression" @default.
- W2017647546 cites W1878166769 @default.
- W2017647546 cites W2035792755 @default.
- W2017647546 cites W2083107662 @default.
- W2017647546 doi "https://doi.org/10.1016/s0041-1345(98)00281-4" @default.
- W2017647546 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9636558" @default.
- W2017647546 hasPublicationYear "1998" @default.
- W2017647546 type Work @default.
- W2017647546 sameAs 2017647546 @default.
- W2017647546 citedByCount "48" @default.
- W2017647546 countsByYear W20176475462014 @default.
- W2017647546 countsByYear W20176475462015 @default.
- W2017647546 countsByYear W20176475462021 @default.
- W2017647546 crossrefType "journal-article" @default.
- W2017647546 hasAuthorship W2017647546A5015939109 @default.
- W2017647546 hasAuthorship W2017647546A5033262794 @default.
- W2017647546 hasAuthorship W2017647546A5035779290 @default.
- W2017647546 hasAuthorship W2017647546A5046333051 @default.
- W2017647546 hasAuthorship W2017647546A5048007683 @default.
- W2017647546 hasAuthorship W2017647546A5054506083 @default.
- W2017647546 hasAuthorship W2017647546A5060244960 @default.
- W2017647546 hasAuthorship W2017647546A5063832474 @default.
- W2017647546 hasAuthorship W2017647546A5066186322 @default.
- W2017647546 hasConcept C126322002 @default.
- W2017647546 hasConcept C134018914 @default.
- W2017647546 hasConcept C141071460 @default.
- W2017647546 hasConcept C168563851 @default.
- W2017647546 hasConcept C203092338 @default.
- W2017647546 hasConcept C2776694085 @default.
- W2017647546 hasConcept C2778033501 @default.
- W2017647546 hasConcept C2780252810 @default.
- W2017647546 hasConcept C2780303639 @default.
- W2017647546 hasConcept C2780873365 @default.
- W2017647546 hasConcept C2909675724 @default.
- W2017647546 hasConcept C2911091166 @default.
- W2017647546 hasConcept C555293320 @default.
- W2017647546 hasConcept C61943457 @default.
- W2017647546 hasConcept C71924100 @default.
- W2017647546 hasConceptScore W2017647546C126322002 @default.
- W2017647546 hasConceptScore W2017647546C134018914 @default.
- W2017647546 hasConceptScore W2017647546C141071460 @default.
- W2017647546 hasConceptScore W2017647546C168563851 @default.
- W2017647546 hasConceptScore W2017647546C203092338 @default.
- W2017647546 hasConceptScore W2017647546C2776694085 @default.
- W2017647546 hasConceptScore W2017647546C2778033501 @default.
- W2017647546 hasConceptScore W2017647546C2780252810 @default.
- W2017647546 hasConceptScore W2017647546C2780303639 @default.
- W2017647546 hasConceptScore W2017647546C2780873365 @default.
- W2017647546 hasConceptScore W2017647546C2909675724 @default.
- W2017647546 hasConceptScore W2017647546C2911091166 @default.
- W2017647546 hasConceptScore W2017647546C555293320 @default.
- W2017647546 hasConceptScore W2017647546C61943457 @default.
- W2017647546 hasConceptScore W2017647546C71924100 @default.
- W2017647546 hasIssue "4" @default.
- W2017647546 hasLocation W20176475461 @default.
- W2017647546 hasLocation W20176475462 @default.
- W2017647546 hasOpenAccess W2017647546 @default.
- W2017647546 hasPrimaryLocation W20176475461 @default.
- W2017647546 hasRelatedWork W1511302864 @default.
- W2017647546 hasRelatedWork W1964116071 @default.
- W2017647546 hasRelatedWork W1965326757 @default.
- W2017647546 hasRelatedWork W1989013906 @default.
- W2017647546 hasRelatedWork W1992117911 @default.
- W2017647546 hasRelatedWork W2011215652 @default.
- W2017647546 hasRelatedWork W2033382768 @default.
- W2017647546 hasRelatedWork W2804610715 @default.
- W2017647546 hasRelatedWork W4206271106 @default.
- W2017647546 hasRelatedWork W4296385041 @default.
- W2017647546 hasVolume "30" @default.
- W2017647546 isParatext "false" @default.
- W2017647546 isRetracted "false" @default.
- W2017647546 magId "2017647546" @default.
- W2017647546 workType "article" @default.