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• W2017654880 abstract "High HIF-2alpha protein levels in the sympathetic nervous system-derived childhood tumour neuroblastoma as well as immature phenotype correlate to unfavourable outcome. Here we show that a small subset of perivascularly located, strongly HIF-2alpha-positive tumour cells (MYCN amplified) lacks expression of differentiation markers, but expresses neural crest and early sympathetic progenitor marker genes such as Notch-1, HES-1, c-Kit, dHAND, and vimentin. HIF-2alpha- and CD68-positive tumour-associated macrophages were frequently found close to the immature and HIF-2alpha-positive neuroblastoma cells and as VEGF levels are high in the perivascular niche, we hypothesize that neuroblastoma neural crest-like cells and macrophages cooperate to facilitate angiogenesis and thereby contribute to the aggressive neuroblastoma phenotype." @default.
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• W2017654880 date "2007-12-11" @default.
• W2017654880 modified "2023-10-04" @default.
• W2017654880 title "High levels of HIF-2α highlight an immature neural crest-like neuroblastoma cell cohort located in a perivascular niche" @default.
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• W2017654880 doi "https://doi.org/10.1002/path.2304" @default.
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