FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017658859> ?p ?o ?g. }

• W2017658859 endingPage "1021" @default.
• W2017658859 startingPage "1007" @default.
• W2017658859 abstract "This study constructed the Economic and Health Outcomes Model for type 2 diabetes mellitus (ECHO-T2DM), a long-term stochastic microsimulation model, to predict the costs and health outcomes in patients with T2DM. Naturally, the usefulness of the model depends upon its predictive accuracy. The objective of this work is to present results of a formal validation exercise of ECHO-T2DM.The validity of ECHO-T2DM was assessed using criteria recommended by the International Society for Pharmacoeconomics and Outcomes Research/Society for Medical Decision Making (ISPOR/SMDM). Specifically, the results of a number of clinical trials were predicted and compared with observed study end-points using a scatterplot and regression approach. An F-test of the best-fitting regression was added to assess whether it differs statistically from the identity (45°) line defining perfect predictions. In addition to testing the full model using all of the validation study data, tests were also performed of microvascular, macrovascular, and survival outcomes separately. The validation tests were also performed separately by type of data (used vs not used to construct the model, economic simulations, and treatment effects).The intercept and slope coefficients of the best-fitting regression line between the predicted outcomes and corresponding trial end-points in the main analysis were -0.0011 and 1.067, respectively, and the R(2) was 0.95. A formal F-test of no difference between the fitted line and the identity line could not be rejected (p = 0.16). The high R(2) confirms that the data points are closely (and linearly) associated with the fitted regression line. Additional analyses identified that disagreement was highest for macrovascular end-points, for which the intercept and slope coefficients were 0.0095 and 1.225, respectively. The R(2) was 0.95 and the estimated intercept and slope coefficients were 0.017 and 1.048, respectively, for mortality, and the F-test was narrowly rejected (p = 0.04). The sub-set of microvascular end-points showed some tendency to over-predict (the slope coefficient was 1.095), although concordance between predictions and observed values could not be rejected (p = 0.16).Important study limitations include: (1) data availability limited one to tests based on end-of-study outcomes rather than time-varying outcomes during the studies analyzed; (2) complex inclusion and exclusion criteria in two studies were difficult to replicate; (3) some of the studies were older and reflect outdated treatment patterns; and (4) the authors were unable to identify published data on resource use and costs of T2DM suitable for testing the validity of the economic calculations.Using conventional methods, ECHO-T2DM simulated the treatment, progression, and patient outcomes observed in important clinical trials with an accuracy consistent with other well-accepted models. Macrovascular outcomes were over-predicted, which is common in health-economic models of diabetes (and may be related to a general over-prediction of event rates in the United Kingdom Prospective Diabetes Study [UKPDS] Outcomes Model). Work is underway in ECHO-T2DM to incorporate new risk equations to improve model prediction." @default.
• W2017658859 created "2016-06-24" @default.
• W2017658859 creator A5046342118 @default.
• W2017658859 creator A5050732320 @default.
• W2017658859 creator A5082515232 @default.
• W2017658859 date "2013-06-26" @default.
• W2017658859 modified "2023-10-18" @default.
• W2017658859 title "Validation of economic and health outcomes simulation model of type 2 diabetes mellitus (ECHO-T2DM)" @default.
• W2017658859 cites W1604542334 @default.
• W2017658859 cites W172609984 @default.
• W2017658859 cites W1964173192 @default.
• W2017658859 cites W1970556989 @default.
• W2017658859 cites W1978146392 @default.
• W2017658859 cites W1994361436 @default.
• W2017658859 cites W2002324192 @default.
• W2017658859 cites W2007057458 @default.
• W2017658859 cites W2009224225 @default.
• W2017658859 cites W2019358675 @default.
• W2017658859 cites W2020572030 @default.
• W2017658859 cites W2034900477 @default.
• W2017658859 cites W2035016472 @default.
• W2017658859 cites W2046335747 @default.
• W2017658859 cites W2060797265 @default.
• W2017658859 cites W2076003266 @default.
• W2017658859 cites W2088900609 @default.
• W2017658859 cites W2090023570 @default.
• W2017658859 cites W2092341553 @default.
• W2017658859 cites W2105671288 @default.
• W2017658859 cites W2107295258 @default.
• W2017658859 cites W2108479359 @default.
• W2017658859 cites W2111759492 @default.
• W2017658859 cites W2124788738 @default.
• W2017658859 cites W2126252058 @default.
• W2017658859 cites W2126563293 @default.
• W2017658859 cites W2134023402 @default.
• W2017658859 cites W2149402195 @default.
• W2017658859 cites W2169355652 @default.
• W2017658859 cites W2171904045 @default.
• W2017658859 cites W2337454357 @default.
• W2017658859 cites W2520696266 @default.
• W2017658859 cites W4213289640 @default.
• W2017658859 doi "https://doi.org/10.3111/13696998.2013.809352" @default.
• W2017658859 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23718682" @default.
• W2017658859 hasPublicationYear "2013" @default.
• W2017658859 type Work @default.
• W2017658859 sameAs 2017658859 @default.
• W2017658859 citedByCount "30" @default.
• W2017658859 countsByYear W20176588592014 @default.
• W2017658859 countsByYear W20176588592015 @default.
• W2017658859 countsByYear W20176588592016 @default.
• W2017658859 countsByYear W20176588592017 @default.
• W2017658859 countsByYear W20176588592018 @default.
• W2017658859 countsByYear W20176588592019 @default.
• W2017658859 countsByYear W20176588592020 @default.
• W2017658859 countsByYear W20176588592021 @default.
• W2017658859 countsByYear W20176588592022 @default.
• W2017658859 countsByYear W20176588592023 @default.
• W2017658859 crossrefType "journal-article" @default.
• W2017658859 hasAuthorship W2017658859A5046342118 @default.
• W2017658859 hasAuthorship W2017658859A5050732320 @default.
• W2017658859 hasAuthorship W2017658859A5082515232 @default.
• W2017658859 hasBestOaLocation W20176588591 @default.
• W2017658859 hasConcept C105795698 @default.
• W2017658859 hasConcept C134018914 @default.
• W2017658859 hasConcept C177713679 @default.
• W2017658859 hasConcept C2776738588 @default.
• W2017658859 hasConcept C2910068830 @default.
• W2017658859 hasConcept C33923547 @default.
• W2017658859 hasConcept C555293320 @default.
• W2017658859 hasConcept C71924100 @default.
• W2017658859 hasConceptScore W2017658859C105795698 @default.
• W2017658859 hasConceptScore W2017658859C134018914 @default.
• W2017658859 hasConceptScore W2017658859C177713679 @default.
• W2017658859 hasConceptScore W2017658859C2776738588 @default.
• W2017658859 hasConceptScore W2017658859C2910068830 @default.
• W2017658859 hasConceptScore W2017658859C33923547 @default.
• W2017658859 hasConceptScore W2017658859C555293320 @default.
• W2017658859 hasConceptScore W2017658859C71924100 @default.
• W2017658859 hasIssue "8" @default.
• W2017658859 hasLocation W20176588591 @default.
• W2017658859 hasLocation W20176588592 @default.
• W2017658859 hasOpenAccess W2017658859 @default.
• W2017658859 hasPrimaryLocation W20176588591 @default.
• W2017658859 hasRelatedWork W1987807347 @default.
• W2017658859 hasRelatedWork W2043967120 @default.
• W2017658859 hasRelatedWork W2084820798 @default.
• W2017658859 hasRelatedWork W2315800989 @default.
• W2017658859 hasRelatedWork W2375214870 @default.
• W2017658859 hasRelatedWork W3008774700 @default.
• W2017658859 hasRelatedWork W3141231889 @default.
• W2017658859 hasRelatedWork W4244001829 @default.
• W2017658859 hasRelatedWork W4297186561 @default.
• W2017658859 hasRelatedWork W4300923219 @default.
• W2017658859 hasVolume "16" @default.
• W2017658859 isParatext "false" @default.
• W2017658859 isRetracted "false" @default.
• W2017658859 magId "2017658859" @default.
• W2017658859 workType "article" @default.