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- W2017659008 abstract "Jorpes1, studying the chemistry of heparin, and, before him, Demole2 and Fischer3, have insisted upon the importance of the—SO3H group for the inhibition of blood-clotting. Link et al.4 have proved that salycilates have an antiprothrombinæmic effect, which is about twenty times weaker than the equivalent dose of ‘Dicumarol’ (Quick5, McKennie6). In order to get comparable data between the retarding influence on blood-clotting and the chemical constitution, we have measured the effect of the following hydrotropic substances in vitro: the sodium salts of phenyl-sulphonic acid, 1,4-oxy-phenyl-sulphonic acid, salycilic acid, 1,3-phenyl-disulphonic acid, 1,3,5-phenyl-trisulphonic acid. The method consists in mixing in small test-tubes 0.1 ml. of normal oxalated blood-plasma (human) with 0.1 ml. of a mixture of phosphate buffer and hydrotropic substance, and 0.2 ml. ‘Thromboplastin’ (Hoffmann–LaRoche, Basle). The phosphate buffer consists of M/30 potassium dihydrogen phosphate and disodium hydrogen phosphate, so as to give a pH of 7.2. It contains, further, sufficient hydrotropic substance to make it one third molar." @default.
- W2017659008 created "2016-06-24" @default.
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- W2017659008 date "1947-08-01" @default.
- W2017659008 modified "2023-09-25" @default.
- W2017659008 title "Influence of Hydrotropic Substances on the Sol/Gel Transformation of Blood Plasma in vitro" @default.
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- W2017659008 doi "https://doi.org/10.1038/160228a0" @default.
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