FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017659945> ?p ?o ?g. }

• W2017659945 endingPage "645" @default.
• W2017659945 startingPage "636" @default.
• W2017659945 abstract "Nerve growth factor (NGF) binds to the TrkA tyrosine kinase and the p75 neurotrophin receptors. Depending upon which receptor is activated, NGF can induce differentiation or apoptosis. C6-2B glioma cells express the p75 receptor, but NGF decreases their growth only when TrkA is introduced (C6trk). It is unclear, however, whether TrkA reduces C6-2B cell growth by apoptosis or differentiation. To examine which mechanisms account for the anti-proliferative effect of NGF in these cells, we first analyzed whether NGF causes apoptosis by flow cytometry, two-site immunoassay and in situ TUNEL. None of these methods indicated that C6trk undergo apoptosis. Additional apoptotic markers, such as Bcl-2, Bax, Bad, p53, caspase 3, and NF-κB were also used. C6trk cells exhibited lower levels of Bcl-2 compared with the parental C6 mock cells, but no changes in the levels of other apoptotic proteins. Moreover, NGF increased AP-1 binding activity in C6trk cells, suggesting that NGF may induce differentiation. We then examined whether TrkA changes the glioma phenotype. In C6trk cells, but not in C6mock cells, NGF enhanced the levels of neuron-specific enolase as well as the levels of A2B5 and 2′, 3′-cyclic nucleotide 3′-phosphodiesterase, markers for oligodendrocytes, without affecting the expression of other neuronal markers. Our data suggest that the antiproliferative properties of TrkA may rely on its ability to induce differentiation of C6 cells from undifferentiated glioma to oligodendrocytes. J. Neurosci. Res. 64:636–645, 2001. © 2001 Wiley-Liss, Inc." @default.
• W2017659945 created "2016-06-24" @default.
• W2017659945 creator A5005988178 @default.
• W2017659945 creator A5012728062 @default.
• W2017659945 creator A5067750470 @default.
• W2017659945 creator A5086700125 @default.
• W2017659945 date "2001-01-01" @default.
• W2017659945 modified "2023-10-11" @default.
• W2017659945 title "TrkA induces differentiation but not apoptosis in C6-2B glioma cells" @default.
• W2017659945 cites W1500669132 @default.
• W2017659945 cites W1949340009 @default.
• W2017659945 cites W1953570960 @default.
• W2017659945 cites W1964610381 @default.
• W2017659945 cites W1966094651 @default.
• W2017659945 cites W1968825318 @default.
• W2017659945 cites W1973060929 @default.
• W2017659945 cites W1974294652 @default.
• W2017659945 cites W1974899939 @default.
• W2017659945 cites W1976917997 @default.
• W2017659945 cites W1977379434 @default.
• W2017659945 cites W1981288686 @default.
• W2017659945 cites W1986841583 @default.
• W2017659945 cites W1990073151 @default.
• W2017659945 cites W1991755309 @default.
• W2017659945 cites W1996901649 @default.
• W2017659945 cites W2000646975 @default.
• W2017659945 cites W2016074466 @default.
• W2017659945 cites W2020826571 @default.
• W2017659945 cites W2021812680 @default.
• W2017659945 cites W2022692782 @default.
• W2017659945 cites W2023777013 @default.
• W2017659945 cites W2030333887 @default.
• W2017659945 cites W2039590096 @default.
• W2017659945 cites W2041490149 @default.
• W2017659945 cites W2051219590 @default.
• W2017659945 cites W2056220988 @default.
• W2017659945 cites W2063176993 @default.
• W2017659945 cites W2063429338 @default.
• W2017659945 cites W2063695629 @default.
• W2017659945 cites W2065136893 @default.
• W2017659945 cites W2065233076 @default.
• W2017659945 cites W2065572121 @default.
• W2017659945 cites W2074575684 @default.
• W2017659945 cites W2075359666 @default.
• W2017659945 cites W2081433269 @default.
• W2017659945 cites W2081555648 @default.
• W2017659945 cites W2091689466 @default.
• W2017659945 cites W2099628695 @default.
• W2017659945 cites W2104234098 @default.
• W2017659945 cites W2123297155 @default.
• W2017659945 cites W2124221273 @default.
• W2017659945 cites W2125278993 @default.
• W2017659945 cites W2134979684 @default.
• W2017659945 cites W2153774847 @default.
• W2017659945 cites W2154127937 @default.
• W2017659945 cites W2163763677 @default.
• W2017659945 cites W2170793285 @default.
• W2017659945 cites W2304355572 @default.
• W2017659945 cites W2332886051 @default.
• W2017659945 cites W2402437850 @default.
• W2017659945 cites W4210656374 @default.
• W2017659945 cites W4253140677 @default.
• W2017659945 doi "https://doi.org/10.1002/jnr.1117" @default.
• W2017659945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11398188" @default.
• W2017659945 hasPublicationYear "2001" @default.
• W2017659945 type Work @default.
• W2017659945 sameAs 2017659945 @default.
• W2017659945 citedByCount "13" @default.
• W2017659945 countsByYear W20176599452012 @default.
• W2017659945 countsByYear W20176599452020 @default.
• W2017659945 countsByYear W20176599452021 @default.
• W2017659945 crossrefType "journal-article" @default.
• W2017659945 hasAuthorship W2017659945A5005988178 @default.
• W2017659945 hasAuthorship W2017659945A5012728062 @default.
• W2017659945 hasAuthorship W2017659945A5067750470 @default.
• W2017659945 hasAuthorship W2017659945A5086700125 @default.
• W2017659945 hasConcept C104317684 @default.
• W2017659945 hasConcept C148738053 @default.
• W2017659945 hasConcept C153911025 @default.
• W2017659945 hasConcept C170493617 @default.
• W2017659945 hasConcept C171034665 @default.
• W2017659945 hasConcept C185592680 @default.
• W2017659945 hasConcept C190283241 @default.
• W2017659945 hasConcept C2778423431 @default.
• W2017659945 hasConcept C502942594 @default.
• W2017659945 hasConcept C55493867 @default.
• W2017659945 hasConcept C56703729 @default.
• W2017659945 hasConcept C86803240 @default.
• W2017659945 hasConcept C92020748 @default.
• W2017659945 hasConcept C95444343 @default.
• W2017659945 hasConceptScore W2017659945C104317684 @default.
• W2017659945 hasConceptScore W2017659945C148738053 @default.
• W2017659945 hasConceptScore W2017659945C153911025 @default.
• W2017659945 hasConceptScore W2017659945C170493617 @default.
• W2017659945 hasConceptScore W2017659945C171034665 @default.
• W2017659945 hasConceptScore W2017659945C185592680 @default.
• W2017659945 hasConceptScore W2017659945C190283241 @default.
• W2017659945 hasConceptScore W2017659945C2778423431 @default.

• next