Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017666786> ?p ?o ?g. }
- W2017666786 abstract "Concomitant expression of mutant p53 and oncogenic Ras, leading to cellular transformation, is well documented. However, the mechanisms by which the various mutant p53 categories cooperate with Ras remain largely obscure. In this study we suggest that different mutant p53 categories cooperate with H-Ras in different manners to induce a unique expression pattern of a cancer related gene signature (CGS). The DNA-contact p53 mutants (p53R248Q and p53R273H) exhibited the highest level of CGS expression by cooperating with NFκB. Furthermore, the Zn+2 region conformational p53 mutants (p53R175H and p53H179R) induced the CGS by elevating H-Ras activity. This elevation in H-Ras activity stemmed from a perturbed function of the p53 transcription target gene, BTG2. In contrast, the L3 loop region conformational mutant (p53G245S) did not affect the CGS expression. Our findings were further corroborated in human tumor-derived cell lines expressing Ras and the aforementioned mutated p53 proteins. These data might assist in future tailor-made therapy which targets the mutant p53-Ras axis in cancer." @default.
- W2017666786 created "2016-06-24" @default.
- W2017666786 creator A5002408024 @default.
- W2017666786 creator A5002972268 @default.
- W2017666786 creator A5006209127 @default.
- W2017666786 creator A5011059517 @default.
- W2017666786 creator A5020335941 @default.
- W2017666786 creator A5032492224 @default.
- W2017666786 creator A5038136290 @default.
- W2017666786 creator A5044435788 @default.
- W2017666786 creator A5068008988 @default.
- W2017666786 creator A5068240181 @default.
- W2017666786 creator A5068783230 @default.
- W2017666786 creator A5079778272 @default.
- W2017666786 date "2012-01-01" @default.
- W2017666786 modified "2023-10-17" @default.
- W2017666786 title "Various p53 mutant types differently regulate the Ras circuit to induce a cancer-related gene signature" @default.
- W2017666786 cites W1816956670 @default.
- W2017666786 cites W1968075505 @default.
- W2017666786 cites W1986415115 @default.
- W2017666786 cites W1991494214 @default.
- W2017666786 cites W1993329740 @default.
- W2017666786 cites W1995095999 @default.
- W2017666786 cites W2003090246 @default.
- W2017666786 cites W2004446628 @default.
- W2017666786 cites W2005542290 @default.
- W2017666786 cites W2017316655 @default.
- W2017666786 cites W2020546422 @default.
- W2017666786 cites W2024883471 @default.
- W2017666786 cites W2025727499 @default.
- W2017666786 cites W2042316019 @default.
- W2017666786 cites W2047596219 @default.
- W2017666786 cites W2054188457 @default.
- W2017666786 cites W2065195919 @default.
- W2017666786 cites W2066696278 @default.
- W2017666786 cites W2068881539 @default.
- W2017666786 cites W2073204626 @default.
- W2017666786 cites W2079511965 @default.
- W2017666786 cites W2080719056 @default.
- W2017666786 cites W2082833890 @default.
- W2017666786 cites W2083695927 @default.
- W2017666786 cites W2088627026 @default.
- W2017666786 cites W2091942447 @default.
- W2017666786 cites W2094957670 @default.
- W2017666786 cites W2096216039 @default.
- W2017666786 cites W2096276671 @default.
- W2017666786 cites W2096353669 @default.
- W2017666786 cites W2110543658 @default.
- W2017666786 cites W2124380422 @default.
- W2017666786 cites W2148817007 @default.
- W2017666786 cites W2154504271 @default.
- W2017666786 cites W2171218640 @default.
- W2017666786 cites W2172010722 @default.
- W2017666786 cites W2783677708 @default.
- W2017666786 doi "https://doi.org/10.1242/jcs.099663" @default.
- W2017666786 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22427690" @default.
- W2017666786 hasPublicationYear "2012" @default.
- W2017666786 type Work @default.
- W2017666786 sameAs 2017666786 @default.
- W2017666786 citedByCount "58" @default.
- W2017666786 countsByYear W20176667862013 @default.
- W2017666786 countsByYear W20176667862014 @default.
- W2017666786 countsByYear W20176667862015 @default.
- W2017666786 countsByYear W20176667862016 @default.
- W2017666786 countsByYear W20176667862017 @default.
- W2017666786 countsByYear W20176667862018 @default.
- W2017666786 countsByYear W20176667862019 @default.
- W2017666786 countsByYear W20176667862020 @default.
- W2017666786 countsByYear W20176667862021 @default.
- W2017666786 countsByYear W20176667862022 @default.
- W2017666786 crossrefType "journal-article" @default.
- W2017666786 hasAuthorship W2017666786A5002408024 @default.
- W2017666786 hasAuthorship W2017666786A5002972268 @default.
- W2017666786 hasAuthorship W2017666786A5006209127 @default.
- W2017666786 hasAuthorship W2017666786A5011059517 @default.
- W2017666786 hasAuthorship W2017666786A5020335941 @default.
- W2017666786 hasAuthorship W2017666786A5032492224 @default.
- W2017666786 hasAuthorship W2017666786A5038136290 @default.
- W2017666786 hasAuthorship W2017666786A5044435788 @default.
- W2017666786 hasAuthorship W2017666786A5068008988 @default.
- W2017666786 hasAuthorship W2017666786A5068240181 @default.
- W2017666786 hasAuthorship W2017666786A5068783230 @default.
- W2017666786 hasAuthorship W2017666786A5079778272 @default.
- W2017666786 hasBestOaLocation W20176667861 @default.
- W2017666786 hasConcept C104317684 @default.
- W2017666786 hasConcept C121608353 @default.
- W2017666786 hasConcept C143065580 @default.
- W2017666786 hasConcept C150194340 @default.
- W2017666786 hasConcept C153911025 @default.
- W2017666786 hasConcept C54355233 @default.
- W2017666786 hasConcept C86803240 @default.
- W2017666786 hasConcept C95444343 @default.
- W2017666786 hasConcept C96232424 @default.
- W2017666786 hasConceptScore W2017666786C104317684 @default.
- W2017666786 hasConceptScore W2017666786C121608353 @default.
- W2017666786 hasConceptScore W2017666786C143065580 @default.
- W2017666786 hasConceptScore W2017666786C150194340 @default.
- W2017666786 hasConceptScore W2017666786C153911025 @default.
- W2017666786 hasConceptScore W2017666786C54355233 @default.
- W2017666786 hasConceptScore W2017666786C86803240 @default.